Newest first

New topics page 15

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 15 of 40

Topic	Participants	Replies	Views	Activity
What to include when your question involves a laboratory result — a second dataset Start Here › How to Ask onboarding guidelines worked example site feedback Solved What to include when your question involves a laboratory result — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context…		2	7k	23d
Why chargeback is not the safety net people assume Sourcing › Payments research use only payments documentation quality Solved Asking directly, because I could not find a straight answer: Why chargeback is not the safety net people assume A logistics question, since the answers here are usually better than anywhere else I have…	+22	26	2.5k	2d
Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose Practice › Administration subcutaneous injection needle gauge & length missed dose Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case…	+18	22	2k	25d
Cold solution and stinging: the simplest fix Practice › Administration injection site rotation subcutaneous injection missed dose Posting this under the heading it deserves: Cold solution and stinging: the simplest fix Everything below is what sits behind that. Reporting something rather than asking about it, in case the pattern is…	+35	39	8.2k	30d
Why this community will not facilitate a group purchase Sourcing › Payments documentation quality payments research use only Asking directly, because I could not find a straight answer: Why this community will not facilitate a group purchase A logistics question, since the answers here are usually better than anywhere else I have…		2	40k	3mo
[2026 update] A rising related-substance total over six months: degradation or method drift? Analytics › Impurities & related substances forced degradation water content endotoxin testing HPLC Solved Wiki The question in the title: A rising related-substance total over six months: degradation or method drift? I will give what I have already checked below so nobody repeats it. Posting the method first, because…	+71	78	34k	5mo
Documenting a payment dispute without naming and shaming — the long version Sourcing › Payments documentation quality payments research use only Posting this under the heading it deserves: Documenting a payment dispute without naming and shaming — the long version Everything below is what sits behind that. I would like to talk about documentation…		2	32k	1mo
PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea type 2 diabetes On the subject in the title: PCOS and metabolic overlap: what is and is not studied Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in this…		3	6.6k	1d
Seven-day rolling means and why weekly readings mislead — one year on Outcomes › Progress reports DXA data table long read Solved On the subject in the title: Seven-day rolling means and why weekly readings mislead — one year on Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without…	+78	88	16k	5mo
GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+90	98	30k	22h
Sample size intuition for a personal experiment — does this still hold? Research Methods › Statistics effect size heterogeneity number needed to treat Solved Sample size intuition for a personal experiment — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med , 2021) with…	+33	38	26k	23d
[2026 update] Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water cloudy or discoloured solution Posting this under the heading it deserves: Buffers, pH and why a formulation is a formulation Everything below is what sits behind that. Working through the identity arithmetic and I would like it checked.…		2	773	3mo
Hepatic impairment and the absence of data — a second dataset Clinical › Special populations adolescents disordered eating pregnancy & planning older adults Pinned On the subject in the title: Hepatic impairment and the absence of data — a second dataset Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in…		2	4.3k	4mo
MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Analytics › Mass spectrometry charge states LC-MS MALDI-TOF counter-ion content Closed Posting this under the heading it deserves: MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Everything below is what sits behind that. Working through the identity…	+34	39	21k	1mo
A site rotation scheme that is easy enough to actually follow Practice › Administration needle gauge & length missed dose injection site rotation aseptic technique On the subject in the title: A site rotation scheme that is easy enough to actually follow Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly…	+112	125	5.8k	21h
Reading a regulatory notice rather than an article about it Sourcing › Regulatory compounding personal import EMA Posting this under the heading it deserves: Reading a regulatory notice rather than an article about it Everything below is what sits behind that. Structured report rather than an opinion, following the…		2	2.9k	5mo
A promotion I argued against, and why I lost — a second dataset Documentation › Doc review citation check promoted to docs wiki post A promotion I argued against, and why I lost — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation…	+3	7	32k	12h
Molecular mass of semaglutide and why the figure differs between sources Compounds › Semaglutide SELECT trial effect size semaglutide STEP programme Molecular mass of semaglutide and why the figure differs between sources — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 4 ( JAMA , 2021)…	+101	110	12k	16h
Research-use-only status: what it means legally and practically Compounds › Other compounds research use only custom synthesis needs a source mislabelling Research-use-only status: what it means legally and practically Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+72	81	44k	1d
Measurement error in home scales, with a worked standard deviation Research Methods › Statistics effect size heterogeneity number needed to treat confounding Solved Wiki Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 1 ( N Engl…	+26	31	4.3k	4mo
Trust level 3 requirements: a clarification — does this still hold? Meta › Announcements trust levels moderation site feedback guidelines Solved Asking directly, because I could not find a straight answer: Trust level 3 requirements: a clarification — does this still hold? Process question about how this site works. I have read the guidelines and the…	+76	90	57k	9h
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+38	43	29k	13h
Gradient steepness and apparent purity: a worked comparison — the long version Analytics › HPLC & UHPLC HPLC system suitability gradient method Gradient steepness and apparent purity: a worked comparison — the long version — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…		2	32k	1d
Is there a ceiling dose beyond which semaglutide stops adding benefit? Compounds › Semaglutide effect size type 2 diabetes SELECT trial Is there a ceiling dose beyond which semaglutide stops adding benefit? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in…		2	14k	2mo
Second pass at: Choosing a concentration on purpose rather than by accident Practice › Reconstitution reconstitution syringe units concentration maths Second pass at: Choosing a concentration on purpose rather than by accident Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about…	+49	54	6k	4mo
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+100	106	35k	2d
Revisiting: Liver enzymes drifting down and what that usually means Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase On the subject in the title: Revisiting: Liver enzymes drifting down and what that usually means Working notes rather than a conclusion. General question, not a request for advice about my own care — I know…	+55	61	39k	3h
A supplier who responds to a discrepancy with silence — what changed since Sourcing › Red flags mislabelling disputed documentation quality underdosing Wiki A supplier who responds to a discrepancy with silence — what changed since — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better…	+83	88	21k	6h
Reading a home test result without over-claiming — what changed since Analytics › Home & field testing third-party testing documentation quality LOD & LOQ ELISA Pinned Closed On the subject in the title: Reading a home test result without over-claiming — what changed since Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…		2	12k	6mo
A fridge failure and how I assessed the contents afterwards Devices › Cold chain cold chain storage temperature excursion A fridge failure and how I assessed the contents afterwards Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a gap,…	+14	18	46k	17h