Newest first

New topics page 14

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 14 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: How to disagree with an answer you were given, well Start Here › How to Ask onboarding worked example guidelines site feedback How to disagree with an answer you were given, well I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to include…		2	16k	30d
CJC-1295 with and without DAC: what the modification does Compounds › Secretagogues & GH axis needs a source tesamorelin CJC-1295 GHRP class On the subject in the title: CJC-1295 with and without DAC: what the modification does Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with SURMOUNT-OSA ( N Engl J Med ,…	+117	123	5.6k	22h
Follow-up: Patterns that reliably precede a problem, documented Sourcing › Red flags underdosing disputed documentation quality Solved On the subject in the title: Patterns that reliably precede a problem, documented Working notes rather than a conclusion. A logistics question, since the answers here are usually better than anywhere else I…		2	70	1d
Preservatives: function, testing, and limits — one year on Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. tirzepatide…	+28	32	437	8d
A widely repeated interaction claim that turns out to be unsupported — what changed since Practice › Interactions insulin hypoglycaemia metformin needs a source Solved A widely repeated interaction claim that turns out to be unsupported — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on…	+89	94	5.9k	2h
Coming back to: Light exposure: how much protection is proportionate? Practice › Storage & stability temperature excursion cold chain freeze-thaw cloudy or discoloured solution Asking directly, because I could not find a straight answer: Light exposure: how much protection is proportionate? Practical question with the units stated, because I have seen how quickly these go wrong…	+5	10	13k	2d
Preprint servers and what screening they do — the long version Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+7	11	26k	4mo
When a dose reduction is the correct response to a side effect Practice › Dosing & titration dose reduction tirzepatide titration missed dose Solved When a dose reduction is the correct response to a side effect — that is the question, and I have not found it answered plainly anywhere I have looked. A question about technique rather than about dose. I…	+38	42	2.7k	19h
Revisiting: Maintainer handover: how it works Meta › Wiki maintenance maintainership review date wiki post moderation Solved Revisiting: Maintainer handover: how it works Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the guidelines and the…	+53	57	664	4mo
Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration tirzepatide dose reduction titration semaglutide Solved Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…	+124	133	11k	5mo
Prescription portability between countries — the long version Access › International EMA NHS telehealth On the subject in the title: Prescription portability between countries — the long version Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category…		2	182	21h
[2026 update] Regional warehouse stock versus direct despatch Sourcing › Logistics packaging customs shipping cold chain Regional warehouse stock versus direct despatch Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+135	147	32k	2d
What other technical communities get right that we do not Lounge › Off topic beginner friendly long read Wiki What other technical communities get right that we do not — that is the question, and I have not found it answered plainly anywhere I have looked. Lower-stakes topic, but the sourcing rule still applies if…	+2	6	23k	5h
Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data tesamorelin needs a source GHRP class Wiki Asking directly, because I could not find a straight answer: Why this subcategory is stricter about sourcing than most Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+48	52	617	21d
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Analytics › Method validation LOD & LOQ system suitability linearity stability-indicating method Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Working through the identity arithmetic and I would like it…	+10	14	13k	5mo
The headache that turns out to be dehydration — the long version Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate Under review On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a…	+68	73	1.3k	12h
About the Special populations category Clinical › Special populations older adults pregnancy & planning adolescents Pinned Wiki Older adults, pregnancy and pregnancy planning, adolescents, renal and hepatic impairment, bariatric surgery history. This post is a community wiki: any member at trust level 3 or above can edit it, and every…		4	3k	4mo
Resolution and tailing factor: real acceptance criteria Analytics › HPLC & UHPLC HPLC gradient method peak integration system suitability Resolution and tailing factor: real acceptance criteria Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…		2	15k	1mo
Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club journal club estimand randomised trial Journal club: orforglipron phase 2 and the non-peptide question Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support…	+120	132	13k	1d
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+104	110	16k	2d
Coming back to: Why I now write the concentration on the vial in marker Practice › Reconstitution reconstitution syringe units bacteriostatic water worked example The question in the title: Why I now write the concentration on the vial in marker I will give what I have already checked below so nobody repeats it. Practical question with the units stated, because I have…	+8	12	4.3k	1d
About the Doc review category Documentation › Doc review wiki post promoted to docs citation check Pinned Wiki Review of drafts and revisions before and after promotion. Every promotion is discussed in public. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	25k	4mo
Mass error in ppm: the arithmetic and the caveat Analytics › Mass spectrometry LC-MS high-resolution MS MALDI-TOF counter-ion content Solved Mass error in ppm: the arithmetic and the caveat Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+108	125	1.5k	5mo
[2026 update] Composite endpoints and the component doing the work Evidence › Trials surrogate endpoints discontinuation & dropout estimand On the subject in the title: Composite endpoints and the component doing the work Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet , 2021) and…	+76	87	994	3mo
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Compounds › Retatrutide randomised trial effect size TRIUMPH programme retatrutide Solved Asking directly, because I could not find a straight answer: What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Session topic: STEP 2 ( Lancet , 2021). Please read…	+43	47	5.5k	just now
Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues cagrilintide amylin analogues cagrisema Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it…	+70	76	3k	4mo
Second pass at: Identical chromatograms across two different lots Sourcing › Red flags disputed mislabelling moderation Posting this under the heading it deserves: Second pass at: Identical chromatograms across two different lots Everything below is what sits behind that. A logistics question, since the answers here are…	+81	93	13k	4mo
About the HPLC & UHPLC category Analytics › HPLC & UHPLC HPLC peak integration gradient method Pinned Wiki Reversed-phase separations, gradients, columns, integration, and reading a chromatogram properly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	137	18h
Type 2 diabetes and the largest part of the evidence base Clinical › Comorbidities chronic kidney disease obstructive sleep apnoea type 2 diabetes MASH / hepatic steatosis Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. General question, not a request for advice about my own care —…	+81	89	2.9k	3mo
A genuinely late dose: what the labelling says and what people do Practice › Administration injection site rotation missed dose needle gauge & length injection site reaction On the subject in the title: A genuinely late dose: what the labelling says and what people do Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is…		2	18k	5mo