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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 12 of 40

Topic	Participants	Replies	Views	Activity
Coming back to: When a red flag was a misunderstanding, and the retraction Sourcing › Red flags mislabelling moderation documentation quality When a red flag was a misunderstanding, and the retraction I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the answers here are usually…	+6	10	257	21h
Requesting a translation of an existing page — the long version Documentation › Wiki requests promoted to docs wiki post review date maintainership Closed Posting this under the heading it deserves: Requesting a translation of an existing page — the long version Everything below is what sits behind that. Process question about how this site works. I have read…	+2	6	5.4k	3mo
Second pass at: When your prescriber and the evidence disagree Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth prior authorisation Pinned Second pass at: When your prescriber and the evidence disagree — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+51	55	9.2k	2d
Joined after a search result and stayed Lounge › Introductions beginner friendly onboarding Posting this under the heading it deserves: Joined after a search result and stayed Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+5	9	26k	7h
Follow-up: Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+62	67	12k	9h
[2026 update] Distinguishing expected GI effects from something that needs urgent attention Practice › Side effects vomiting fatigue constipation delayed gastric emptying On the subject in the title: Distinguishing expected GI effects from something that needs urgent attention Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+10	14	11k	4mo
Which fields on a certificate actually matter, ranked Analytics › COA interpretation reference standards certificate of analysis documentation quality batch & lot numbers Closed Which fields on a certificate actually matter, ranked — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first three…	+25	29	46k	4mo
[2026 update] Charge states for a 4 kDa peptide, worked through Analytics › Mass spectrometry counter-ion content MALDI-TOF high-resolution MS LC-MS On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…	+116	135	31k	3mo
Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides BPC-157 observational data preprint TB-500 Oral versus injected administration claims for BPC-157 — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think…	+20	24	47k	4mo
Comparing the STEP programme populations: who was actually enrolled Compounds › Semaglutide SELECT trial STEP programme semaglutide effect size Solved Comparing the STEP programme populations: who was actually enrolled Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med , 2021) with FLOW ( N…		2	7.5k	2mo
Follow-up: Request: a per-category review queue Meta › Feature requests translation site feedback wiki post Closed On the subject in the title: Request: a per-category review queue Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question keeps being…		2	14k	4mo
About the Comorbidities category Clinical › Comorbidities type 2 diabetes chronic kidney disease MASH / hepatic steatosis Pinned Wiki Type 2 diabetes, hepatic steatosis, sleep apnoea, cardiovascular and renal disease. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	16k	12h
System suitability injections: if they failed, the run did not happen — the long version Analytics › HPLC & UHPLC gradient method UV & DAD detection system suitability peak integration System suitability injections: if they failed, the run did not happen — the long version — setting out what I have, and where I think it stops being reliable. A documentation question rather than an…	+2	6	6.2k	1d
About the Impurities & related substances category Analytics › Impurities & related substances forced degradation counter-ion content water content Pinned Wiki Deletion sequences, oxidation, deamidation, aggregates, residual solvents, and counter-ion content. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+6	10	50k	15h
Reading a preclinical wound-healing model and its relevance to a human tendon — a second dataset Compounds › Repair & healing peptides observational data preprint BPC-157 Reading a preclinical wound-healing model and its relevance to a human tendon — a second dataset — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016)…	+64	69	27k	4mo
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Evidence › Journal club risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med ,…	+18	22	656	13h
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Lounge › Introductions beginner friendly onboarding Posting this under the heading it deserves: Introducing myself: pharmacist, sceptic, reluctant participant — one year on Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule…	+101	107	14k	4mo
Coming back to: How much context is too much context in a first post? Start Here › How to Ask beginner friendly site feedback worked example onboarding Asking directly, because I could not find a straight answer: How much context is too much context in a first post? Question in the title. Context below, and I have tried to include the things people here…	+2	6	7.5k	1d
Citing a preprint in a maintained document: our rule and its reasoning Evidence › Preprints risk of bias effect size needs a source preprint Pinned On the subject in the title: Citing a preprint in a maintained document: our rule and its reasoning Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a…		2	467	4mo
About the Sleep category Wellbeing › Sleep obstructive sleep apnoea fatigue heart rate Pinned Wiki Sleep quality, apnoea, and the bidirectional relationship with metabolic health. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…	+1	5	92	4mo
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Compounds › Oral incretins randomised trial oral semaglutide SOUL trial PIONEER programme Posting this under the heading it deserves: Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022)…	+27	31	17k	25d
Insomnia at a dose step: reported experiences — the long version Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Solved Pinned Insomnia at a dose step: reported experiences — the long version Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+47	51	31k	1d
Revisiting: Body image changing more slowly than the body Wellbeing › Mental health disordered eating mood beginner friendly Solved Posting this under the heading it deserves: Revisiting: Body image changing more slowly than the body Everything below is what sits behind that. General question, not a request for advice about my own care —…	+5	9	28k	8h
Subgroup analyses: pre-specified versus discovered — a second dataset Evidence › Trials open label discontinuation & dropout estimand randomised trial On the subject in the title: Subgroup analyses: pre-specified versus discovered — a second dataset Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet ,…	+71	79	906	3mo
Why retatrutide discussion here is more cautious than elsewhere Compounds › Retatrutide randomised trial effect size retatrutide preprint Solved Why retatrutide discussion here is more cautious than elsewhere I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited…	+7	12	7.7k	2mo
Contributing data without breaching anyone's privacy Data & Tools › Datasets data table confounding observational data Solved Contributing data without breaching anyone's privacy Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+65	71	839	5mo
Splitting a weekly dose in two: the pharmacokinetic argument against Practice › Dosing & titration titration tirzepatide semaglutide missed dose Splitting a weekly dose in two: the pharmacokinetic argument against — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I…	+24	28	51k	5mo
Transporting a vial for a weekend away — a second dataset Practice › Storage & stability storage cold chain beyond-use date Transporting a vial for a weekend away — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+74	84	5.1k	1mo
The lowest dose that does anything: is that a real question? Practice › Dosing & titration dose reduction worked example missed dose titration Asking directly, because I could not find a straight answer: The lowest dose that does anything: is that a real question? I have read the maintained page on this and I still have a gap, so I am asking rather…	+100	111	9.1k	5mo
Grapefruit: why this class is not the class that cares Practice › Interactions needs a source hypoglycaemia metformin delayed gastric emptying Grapefruit: why this class is not the class that cares Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+126	139	4k	4mo