Newest first

New topics page 13

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 13 of 40

Topic	Participants	Replies	Views	Activity
Journal club: SURMOUNT-4 and continuation versus withdrawal Evidence › Journal club journal club number needed to treat effect size Journal club: SURMOUNT-4 and continuation versus withdrawal — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not…	+32	36	31k	3mo
Pinch or no pinch, and how needle length changes the answer — what changed since Practice › Administration missed dose aseptic technique injection site rotation Solved Posting this under the heading it deserves: Pinch or no pinch, and how needle length changes the answer — what changed since Everything below is what sits behind that. I have read the maintained page on this…	+58	62	16k	1d
The "under review" status pill and when a moderator applies it Evidence › Preprints risk of bias effect size preprint Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+96	119	17k	3mo
Journal club: indirect comparison between two programmes, defended and attacked Evidence › Journal club journal club randomised trial number needed to treat risk of bias Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016)…	+122	131	5.2k	just now
Coming back to: Swirling versus inverting versus leaving it alone Practice › Reconstitution reconstitution concentration maths syringe units Solved Swirling versus inverting versus leaving it alone Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly…	+20	24	16k	26d
Peer-to-peer review: what actually happens on the call — one year on Access › Insurance & coverage appeals formulary insurance Peer-to-peer review: what actually happens on the call — one year on — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this…	+2	6	41k	5mo
Open-label extensions: what survives and what does not Evidence › Trials discontinuation & dropout randomised trial estimand Closed Posting this under the heading it deserves: Open-label extensions: what survives and what does not Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with PIONEER 6 ( N Engl J Med ,…		4	22k	3mo
Why the timeline is on the right and not the left — what changed since Meta › Site feedback site feedback moderation guidelines Solved Why the timeline is on the right and not the left — what changed since I have a specific reason for asking rather than idle curiosity, and the context is below. Nominating something for promotion into the…	+77	81	4k	2d
Conditions that change the calculus rather than forbidding it Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Conditions that change the calculus rather than forbidding it Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+28	32	6.1k	1d
German, French and Dutch differences, compared Regional › European Union cost per milligram formulary EMA German, French and Dutch differences, compared — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…		2	12k	10h
Drawing up with one needle and injecting with another Practice › Administration injection site rotation missed dose aseptic technique subcutaneous injection On the subject in the title: Drawing up with one needle and injecting with another Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go…	+1	5	6.9k	1d
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues amylin analogues randomised trial effect size cagrisema Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before…	+21	25	44k	5mo
What I would record differently if I started again Outcomes › Progress reports DXA long read data table effect size Closed Asking directly, because I could not find a straight answer: What I would record differently if I started again Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…		2	12k	5mo
About the Interactions category Practice › Interactions insulin metformin hypoglycaemia Pinned Wiki Drug, supplement and food interactions — separating timing inconveniences from clinically important ones. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+4	8	1.9k	2mo
Follow-up: "Should I double up?" — answered once, at length, calmly Practice › Administration needle gauge & length aseptic technique injection site rotation subcutaneous injection On the subject in the title: "Should I double up?" — answered once, at length, calmly Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking…		2	9.7k	5mo
Measurement error in a self-reported exposure Evidence › Study critique confounding risk of bias effect size disputed Solved Closed Posting this under the heading it deserves: Measurement error in a self-reported exposure Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it before…	+117	129	45k	5mo
Fibre intake when total intake falls, and the constipation link — one year on Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Fibre intake when total intake falls, and the constipation link — one year on Everything below is what sits behind that. Longitudinal report with the method stated,…	+9	13	16k	16h
A staff appointment, and what the role involves Meta › Announcements trust levels site feedback moderation Closed On the subject in the title: A staff appointment, and what the role involves Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question…		2	1.8k	4mo
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with STEP 4 (…	+109	116	36k	2d
Air bubbles in a subcutaneous injection: the honest risk assessment — does this still hold? Practice › Administration injection site rotation missed dose aseptic technique subcutaneous injection Wiki Asking directly, because I could not find a straight answer: Air bubbles in a subcutaneous injection: the honest risk assessment — does this still hold? Reporting something rather than asking about it, in…	+21	30	20k	4mo
Counter-ion form: the field almost nobody reports Analytics › COA interpretation certificate of analysis documentation quality batch & lot numbers Solved Counter-ion form: the field almost nobody reports Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…		3	11k	2mo
Second pass at: Where impurities in solid-phase peptide synthesis come from Analytics › Impurities & related substances counter-ion content data table endotoxin testing HPLC Closed Posting this under the heading it deserves: Second pass at: Where impurities in solid-phase peptide synthesis come from Everything below is what sits behind that. A documentation question rather than an…	+47	51	3.3k	5mo
Choosing which test to pay for, given a fixed budget Sourcing › Independent verification third-party testing VendorInvestigate Medutest Janoshik Analytical On the subject in the title: Choosing which test to pay for, given a fixed budget Working notes rather than a conclusion. I would like to talk about documentation quality as a signal, separately from product…	+60	70	49k	3mo
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+55	59	26k	2d
About the Resistance training category Nutrition & Training › Resistance training lean mass loss fatigue DXA Pinned Wiki Programming while losing weight quickly, realistic expectations, and recovery. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…		4	40k	17d
An ABAB design with a data table and honest limitations — a second dataset Research Methods › N-of-1 designs confounding effect size data table worked example Solved On the subject in the title: An ABAB design with a data table and honest limitations — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…	+106	118	25k	4mo
Follow-up: An emergency department visit, described afterwards Safety › Adverse events gallbladder delayed gastric emptying vomiting On the subject in the title: An emergency department visit, described afterwards Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…		4	18k	1mo
Follow-up: I have no scientific background — can I still follow the analytics categories? Start Here › Welcome guidelines beginner friendly trust levels onboarding Solved Asking directly, because I could not find a straight answer: I have no scientific background — can I still follow the analytics categories? Question in the title. Context below, and I have tried to include…	+15	19	15k	1mo
[2026 update] Journal club: PIONEER 6 as a safety trial Evidence › Journal club journal club number needed to treat estimand Journal club: PIONEER 6 as a safety trial Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do not…	+14	18	55k	5mo
[2026 update] Thyroid function tests during substantial weight change Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c thyroid function Thyroid function tests during substantial weight change Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+69	74	4.5k	2mo