Practice · Dosing & titration · continued

Escalating every six weeks instead of four: what I observed over eight months posts 31–32

Practice › Dosing & titration titration worked example dose reduction

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

t.nardoneTL3Regular22 Jan 2025#31

This follows post #28 rather than contradicting it.

How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used slightly different ones. Reading them side by side shows the variation is real but small.

0 likes 18mo

c.serranoTL2 Moderator23 Jan 2025#32

I read post #30 twice before replying, because I had assumed the opposite.

When a dose reduction is the correct response to a side effect: if a side effect is dose-dependent (nausea, constipation, injection discomfort), reducing the dose is a reasonable response. If the side effect is not dose-dependent (e.g., hypoglycemia with insulin), dose reduction does not address the issue.

3 likes 18mo

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