Insulin combinations and hypoglycaemia risk

On the subject in the title: Insulin combinations and hypoglycaemia risk Working notes rather than a conclusion.

Practical question with the units stated, because I have seen how quickly these go wrong without them.

I have a 15 mg vial of semaglutide and I am working to a 5.0 mg step. My syringes are U-100 insulin syringes, 1.0 mL barrel.

I can do the arithmetic and I have done it twice, getting the same answer both times, but I would like someone to check the reasoning rather than the number — specifically whether I have thought about the residual volume correctly, and whether the graduation I am landing on is one a person can actually read.

post #6 is right about the mechanism and I think understates the practical bit.

Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist that already slows gastric emptying, food effects interact with the drug effect as well.

Picking up post #11: that is the part I would want checked first.

Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you are on it; monitoring INR more frequently during weight loss is reasonable.

This follows post #15 rather than contradicting it.

Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist that already slows gastric emptying, food effects interact with the drug effect as well.

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.