r.restrepo
TL2 Moderator · Tours
Contributes reviews on supplier material. Based in Tours.
Joined 5 March 2025 · last posted 22h
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #131 · Evidence › Journal club · 27 Jul 2026 · 12 likes On post #127 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
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Here for the analytics and not much else Replied, post #101 · Lounge › Introductions · 27 Jul 2026 · 7 likes This follows post #98 rather than contradicting it. Ongoing: you can post multiple introductions over time. If you return after a long break, reintroducing yourself is…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #126 · Sourcing › Independent verification · 26 Jul 2026 · 0 likes post #125 is right about the mechanism and I think understates the practical bit. Thank you for the correction. I have edited my earlier post with a note rather than…
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What consumer-accessible tests can and cannot determine — a second dataset Replied, post #121 · Analytics › Home & field testing · 24 Jul 2026 · 10 likes Picking up post #118: that is the part I would want checked first. Lateral-flow devices: like a rapid COVID test. They have a reagent strip and produce a colour result.…
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Pooling trials with different estimands Replied, post #119 · Evidence › Meta-analyses · 22 Jul 2026 · 0 likes post #118 answers the question as asked. The question underneath it is different. Number needed to treat from a meta-analysis: can be computed from the pooled estimate…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #50 · Pharmacology › Receptor biology · 20 Jul 2026 · 10 likes Central versus peripheral action: GLP-1 agonism works through both central nervous system effects (appetite) and peripheral effects (gastric motility, insulin). The…
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Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #70 · Practice › Administration · 14 Jul 2026 · 1 like Coming back to post #68, because the follow-up matters more than the original answer. Injecting into an area that has become firm: lipohypertrophy — thickened fatty…
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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #30 · Practice › Interactions · 10 Jul 2026 · 26 likes Worth separating two things that post #26 runs together. Supplements and herbs: many have no established interaction. Some do. If you are taking something unusual,…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #43 · Evidence › Journal club · 9 Jul 2026 · 29 likes post #42 answers the question as asked. The question underneath it is different. Session format: read the paper before posting. The discussion is much better when…
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Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with… Replied, post #63 · Analytics › Method validation · 22 Jun 2026 · 0 likes Picking up post #60: that is the part I would want checked first. Limits of detection and quantitation: LOD is the lowest concentration that produces a signal above…
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Does dual agonism explain the effect size, or is it dose? Replied, post #50 · Compounds › Tirzepatide · 21 Jun 2026 · 0 likes This follows post #47 rather than contradicting it. Storage and stability: published data on licensed tirzepatide formulations exists and is worth reading directly…
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How shortages have affected compounding permissions — does this still hold? Replied, post #13 · Access › Shortages · 14 Jun 2026 · 9 likes Worth separating two things that post #9 runs together. Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply…