Topic summary

Pregnancy and pregnancy planning: contraindication and washout

Clinical › Special populations pregnancy & planning bariatric surgery history chronic kidney disease disordered eating Closed

This is a generated summary. It shows the 9 most-liked posts from a topic of 123, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

n.laurentTL2 Moderator16 Jan 2026#16

s.ostergaard, post #12: This follows post #9 rather than contradicting it. Pregnancy and planning: these compounds are not approved for use in pregnancy. Planning windows (how long to wait before attempting pregnancy) are not formally established. Conservative approaches wait several months to allow clearance. Go to post

Picking up post #13: that is the part I would want checked first.

Disordered eating history: a history of anorexia nervosa, bulimia, or other eating disorders changes the risk-benefit calculation because appetite suppression might trigger relapse. This population requires specialist input.

31 likes in reply to #12 6mo

j.silvaTL2 Moderator22 Jan 2026#21

so.cardoso, post #19: I read post #17 twice before replying, because I had assumed the opposite. Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

Older adults: sarcopenia risk is higher, polypharmacy is common, and the clinical trials did not enroll many people over 75. Extrapolating to very old people is extrapolating beyond the data.

33 likes in reply to #19 6mo

z.cardosoTL2 Moderator12 Feb 2026#40

post #39 is right about the mechanism and I think understates the practical bit.

Medullary thyroid carcinoma history: an absolute contraindication because of the preclinical findings in rodent toxicology. The history (personal or family, especially multiple endocrine neoplasia type 2) is an important screening question.

27 likes 5mo

mi.amankwahTL2 Moderator16 Feb 2026#44

n.dziedzic, post #9: Pregnancy and planning: these compounds are not approved for use in pregnancy. Planning windows (how long to wait before attempting pregnancy) are not formally established. Conservative approaches wait several months to allow clearance. Go to post

I read post #42 twice before replying, because I had assumed the opposite.

Hepatic impairment: less is known about dosing in significant liver disease than in kidney disease. Extreme caution applies because the liver metabolises a large fraction of many medications.

27 likes in reply to #9 5mo

m.ramosTL2 Moderator6 Mar 2026#64

buffer_review, post #47: Pancreatitis history: the compounds can rarely trigger pancreatitis. A history of pancreatitis makes monitoring for recurrence more important during titration. Go to post

On post #60 — agreed on the reasoning, with one qualification.

Gastroparesis: pre-existing severe delayed gastric emptying can worsen with compounds that slow it further. Discussion with a clinician is prudent if this history exists.

30 likes in reply to #47 5mo

BBramleyTL3Regular11 Mar 2026#69

Picking up post #66: that is the part I would want checked first.

Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar with renal dosing is prudent.

31 likes 5mo

f.chowdhuryTL2 Moderator17 Mar 2026#76

f.kimani, post #54: For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use. Go to post

Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar with renal dosing is prudent.

28 likes in reply to #54 4mo

endo_fellow_rkTL3Endocrinology fellow5 Apr 2026#98

s.dziedzic, post #20: Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar with renal dosing is prudent. Go to post

post #97 answers the question as asked. The question underneath it is different.

32 likes in reply to #20 4mo

m.coelhoTL2 Moderator17 Apr 2026#114

Worth separating two things that post #110 runs together.

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

28 likes 3mo

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