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Intersection · Evidence × meta-analysis

Evidence topics tagged meta-analysis

Topics in Evidence carrying the tag meta-analysis. Quantitative synthesis across studies.

18 topics

TopicParticipantsRepliesViewsActivity
Pooling trials with different estimands
On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding the…
RCFCTSRMME+120 132 2.3k 1d
A pooled estimate that changed when one trial was added
A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…
PMIDOIOO+24 28 3.5k 2d
Second pass at: A pooled estimate that changed when one trial was added
On the subject in the title: Second pass at: A pooled estimate that changed when one trial was added Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…
FLSTYAWNRM+26 30 22k 1mo
Publication bias detection and its low power — does this still hold?
The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N Engl J Med , 2016)…
RCGAKDBSP+24 28 2.4k 3mo
Second pass at: What pooling buys you and what it destroys
Posting this under the heading it deserves: Second pass at: What pooling buys you and what it destroys Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim…
MHCCYMRMBJ+32 36 19k 4mo
Prediction intervals and why they are more honest than confidence intervals
Posting this under the heading it deserves: Prediction intervals and why they are more honest than confidence intervals Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with FLOW…
DBWSRMON+21 25 46k 4mo
Heterogeneity as information rather than as a nuisance
Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…
DFRJMNAN+88 95 1.2k 6mo
Pooling trials with different estimands — what changed since
Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURPASS-4 ( Lancet , 2021) and finding…
BERRMLDYAW+57 64 12k 7mo
What pooling buys you and what it destroys
The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. Comparing SURMOUNT-2 ( Lancet , 2023) with LEADER ( N Engl J Med ,…
MDEHDHPMNA+74 83 6.6k 8mo
Risk-of-bias tools and the judgement they conceal
Risk-of-bias tools and the judgement they conceal Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…
KBHALPMECI+8 12 21k 11mo
[2026 update] Heterogeneity as information rather than as a nuisance
Heterogeneity as information rather than as a nuisance Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…
PSGCCFDCL 4 32k 11mo
Random versus fixed effects: choosing rather than defaulting
Random versus fixed effects: choosing rather than defaulting — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before posting;…
NPFSMLAJS+16 20 22k 13mo
About the Meta-analyses category
Pooled estimates, heterogeneity, publication bias, and when pooling was a mistake. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…
SLDOERZSIT 4 15k 13mo
Individual participant data versus aggregate data
Posting this under the heading it deserves: Individual participant data versus aggregate data Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…
EAKBTEMAK+30 34 64k 14mo
Coming back to: Reading a meta-analysis you disagree with, fairly
Reading a meta-analysis you disagree with, fairly Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…
TVBDJIPMCT+30 34 9.3k 17mo
Follow-up: Individual participant data versus aggregate data
Individual participant data versus aggregate data — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURPASS-4 ( Lancet , 2021) and finding the…
HDAPRSGVRV+101 111 23k 18mo
Second pass at: When a network meta-analysis is defensible and when it is not
Posting this under the heading it deserves: Second pass at: When a network meta-analysis is defensible and when it is not Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with LEADER…
LSOID 2 2.8k 21mo
Coming back to: Prediction intervals and why they are more honest than confidence intervals
Prediction intervals and why they are more honest than confidence intervals Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024)…
TDIBB 2 65 22mo