Ranked by engagement

Top topics — this year page 10

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,076 topics · page 10 of 14

Topic	Participants	Replies	Views	Activity
Adolescents: a distinct evidence base — one year on Clinical › Special populations bariatric surgery history disordered eating pregnancy & planning adolescents Pinned Wiki Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. General question, not a request for advice about my own care — I know…	+78	88	9.3k	3mo
Injection discomfort: needle gauge, volume, temperature, technique Practice › Administration subcutaneous injection injection site reaction needle gauge & length aseptic technique Injection discomfort: needle gauge, volume, temperature, technique — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+66	71	14k	2mo
Pre-registering a personal experiment, seriously — a second dataset Research Methods › N-of-1 designs data table worked example confounding Posting this under the heading it deserves: Pre-registering a personal experiment, seriously — a second dataset Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of…	+60	66	35k	3mo
An 18-month record including the parts that went badly Outcomes › Progress reports data table long read effect size DXA An 18-month record including the parts that went badly — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a method is…	+77	81	17k	12h
Coming back to: Sample size calculations, read backwards from the published number Evidence › Trials estimand discontinuation & dropout surrogate endpoints randomised trial On the subject in the title: Sample size calculations, read backwards from the published number Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+82	88	1.8k	11mo
Distinguishing a deletion sequence by mass alone — the long version Analytics › Mass spectrometry high-resolution MS mass error (ppm) charge states MALDI-TOF On the subject in the title: Distinguishing a deletion sequence by mass alone — the long version Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+38	44	60k	11mo
Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC peak integration UV & DAD detection system suitability HPLC On the subject in the title: Detection wavelength and why 214 nm and 280 nm disagree Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will…	+78	84	1.7k	8mo
Realistic expectations for strength while losing weight quickly Nutrition & Training › Resistance training fatigue DXA lean mass loss Closed Posting this under the heading it deserves: Realistic expectations for strength while losing weight quickly Everything below is what sits behind that. Maintenance rather than loss, which is the part of this…	+60	70	38k	4mo
Hypertension improvement and when medication needs revisiting Clinical › Comorbidities type 2 diabetes MASH / hepatic steatosis chronic kidney disease Closed Hypertension improvement and when medication needs revisiting Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+74	79	1.1k	10mo
How to read a forest plot, properly, from scratch Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Solved The question in the title: How to read a forest plot, properly, from scratch I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 ( JAMA , 2021). Please read it before…	+73	81	17k	7mo
DXA precision and the least significant change for lean mass Outcomes › Body composition bioimpedance data table DXA Closed Posting this under the heading it deserves: DXA precision and the least significant change for lean mass Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…	+81	85	2.7k	7mo
Reflectance and photometric devices: precision in practice — a second dataset Analytics › Home & field testing ELISA LOD & LOQ documentation quality Reflectance and photometric devices: precision in practice — a second dataset — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I…	+75	82	17k	12h
Tracking that stops updating and then resumes — the long version Sourcing › Logistics packaging cold chain shipping Tracking that stops updating and then resumes — the long version — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+61	69	27k	6mo
A comparison of home results against a laboratory result on the same vial Analytics › Home & field testing documentation quality ELISA third-party testing Posting this under the heading it deserves: A comparison of home results against a laboratory result on the same vial Everything below is what sits behind that. Working through the identity arithmetic and I…	+61	65	35k	8mo
Availability by country, dated, with primary sources Access › International EMA MHRA telehealth personal import On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+72	81	6.9k	8mo
Fasting versus non-fasting and which tests care Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c Solved Fasting versus non-fasting and which tests care Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I know the…	+72	78	14k	19h
A history of disordered eating: proceeding carefully Wellbeing › Mental health mood beginner friendly disordered eating A history of disordered eating: proceeding carefully Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+70	75	10k	6mo
Freeze-thaw and why one cycle is not the same as five — a second dataset Practice › Storage & stability storage beyond-use date freeze-thaw Freeze-thaw and why one cycle is not the same as five — a second dataset — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+47	55	46k	10mo
Follow-up: Sleep quality changes during weight loss Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I would…	+74	80	4.4k	14h
What a documentation review can and cannot tell you Sourcing › Independent verification Medutest VendorInvestigate Janoshik Analytical blind sampling Solved Wiki What a documentation review can and cannot tell you — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to talk about documentation quality as a signal,…	+79	83	950	11mo
Pages past their review date, listed — does this still hold? Meta › Wiki maintenance review date moderation maintainership wiki post Asking directly, because I could not find a straight answer: Pages past their review date, listed — does this still hold? Nominating something for promotion into the documentation commons. The topic in…	+49	56	39k	11d
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Revisiting: Absolute versus relative contraindications — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+80	85	7.4k	3mo
Liver enzymes drifting down and what that usually means Clinical › Bloodwork HbA1c liver enzymes eGFR & renal function Solved Closed Liver enzymes drifting down and what that usually means — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+66	72	12k	4mo
[2026 update] Composite endpoints and the component doing the work Evidence › Trials surrogate endpoints discontinuation & dropout estimand On the subject in the title: Composite endpoints and the component doing the work Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet , 2021) and…	+76	87	994	3mo
[2026 update] Thyroid function tests during substantial weight change Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c thyroid function Thyroid function tests during substantial weight change Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+69	74	4.5k	2mo
Why the timeline is on the right and not the left — what changed since Meta › Site feedback site feedback moderation guidelines Solved Why the timeline is on the right and not the left — what changed since I have a specific reason for asking rather than idle curiosity, and the context is below. Nominating something for promotion into the…	+77	81	4k	2d
Why semaglutide solutions can look faintly opalescent and when that matters Compounds › Semaglutide semaglutide SELECT trial randomised trial effect size Solved The question in the title: Why semaglutide solutions can look faintly opalescent and when that matters I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med ,…	+73	79	2k	4mo
How to ask a question when you cannot say why you are asking it Start Here › How to Ask beginner friendly site feedback worked example onboarding Solved Asking directly, because I could not find a straight answer: How to ask a question when you cannot say why you are asking it Question in the title. Context below, and I have tried to include the things people…	+49	53	36k	4h
Primary endpoint hierarchies and why order matters — one year on Evidence › Trials surrogate endpoints discontinuation & dropout estimand randomised trial Solved On the subject in the title: Primary endpoint hierarchies and why order matters — one year on Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURPASS-2 ( N Engl J Med ,…	+56	61	37k	11h
Comparing my trajectory with the trial curves, carefully — a second dataset Outcomes › Progress reports effect size data table long read Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that…	+77	81	16k	11h