a.cardoso
TL2 Moderator · Braga
Contributes reviews on supplier material. Based in Braga.
Joined 18 September 2025 · last posted 2d
84Posts here
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GIP receptor agonism and the argument about direction Started this topic · Pharmacology › Receptor biology · 7 Jun 2025 · 40 likes GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know…
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One lot is one lot: when a report becomes a pattern — the long version Replied, post #53 · Sourcing › Vendor reports · 16 Mar 2025 · 32 likes Temporal patterns: if results from a supplier were good two years ago but have deteriorated recently, that is information. If they have been consistent over years, that…
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Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #91 · Clinical › Special populations · 3 Feb 2026 · 31 likes Pregnancy and planning: these compounds are not approved for use in pregnancy. Planning windows (how long to wait before attempting pregnancy) are not formally…
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Coming back to: Washout: how long is long enough, and for what purpose Replied, post #10 · Pharmacology › Pharmacokinetics · 7 Jan 2026 · 29 likes Renal clearance: these compounds are cleared partly via the kidney. In severe renal impairment, clearance is slowed and accumulation risk is higher. Dose adjustments…
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Journal club: the CagriSema phase 2 combination paper — a second dataset Replied, post #2 · marked as the solution · Evidence › Journal club · 10 May 2025 · 25 likes SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome trial in people without diabetes, which decoupled the cardiovascular…
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Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #59 · Evidence › Journal club · 6 Jul 2026 · 23 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
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