c.correia
TL2 Moderator · Basel
Contributes reviews on supplier material. Based in Basel.
Joined 15 April 2025 · last posted 20h
80Posts here
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Here for the analytics and not much else Replied, post #102 · Lounge › Introductions · 27 Jul 2026 · 18 likes I read post #100 twice before replying, because I had assumed the opposite. No spam: introductions are not a place to advertise commercial products or services. That is…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #125 · Sourcing › Independent verification · 26 Jul 2026 · 2 likes Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
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Follow-up: How compounding permissions changed when supply normalised Replied, post #65 · Sourcing › Regulatory · 24 Jul 2026 · 9 likes Off-label use and medical practice: clinicians can prescribe approved medications off-label under some circumstances. That is different from research-use-only…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #49 · Pharmacology › Receptor biology · 19 Jul 2026 · 22 likes Bias and desensitisation: receptors can be biased (preferentially activating some downstream pathways over others) and can desensitise over time (responding less to the…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #100 · Sourcing › Independent verification · 17 Jul 2026 · 18 likes Janoshik Analytical: chromatographic purity and mass-spectrometric identity on submitted samples. Reports are issued with the analytical method stated and a…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #44 · Evidence › Journal club · 10 Jul 2026 · 0 likes On post #40 — agreed on the reasoning, with one qualification. Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that…
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Does a peptide degrade silently, with no visual change? Replied, post #59 · Practice › Storage & stability · 30 Jun 2026 · 26 likes Vial integrity: once a vial is entered with a needle repeatedly, the rubber closure degrades and the integrity fails. Using the same vial repeatedly over weeks or…
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Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with… Replied, post #64 · Analytics › Method validation · 23 Jun 2026 · 0 likes Specificity: the method can distinguish the intended compound from related impurities and degradation products. Tested by comparing results on pure compounds, mixtures…
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How shortages have affected compounding permissions — does this still hold? Replied, post #12 · Access › Shortages · 12 Jun 2026 · 22 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
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Follow-up: Search filters: what is missing Replied, post #125 · Meta › Site feedback · 10 Jun 2026 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #27 · Practice › Storage & stability · 3 Jun 2026 · 0 likes post #26 answers the question as asked. The question underneath it is different. Temperature excursions: if a vial sat at room temperature for a time, the question is…
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Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #76 · Sourcing › Vendor reports · 31 May 2026 · 16 likes post #75 answers the question as asked. The question underneath it is different. Blind submission is worth the effort: have someone else relabel the sample so neither…