f.kimani
TL2 Moderator · Utrecht
Contributes reviews on supplier material. Based in Utrecht.
Joined 18 December 2024 · last posted 1h
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Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #85 · Compounds › Cagrilintide & amylin analogues · 22 Mar 2025 · 33 likes The dosing interval: cagrilintide's half-life is roughly 7 to 8 days, suitable for weekly dosing. The pharmacokinetics are the reason the dosing schedule makes sense.
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About the Receptor biology category Replied, post #11 · Pharmacology › Receptor biology · 7 Jul 2026 · 29 likes Glucagon receptor agonism: glucagon receptor agonism increases energy expenditure and promotes hepatic fat oxidation. The mechanism is distinct from GLP-1 and GIP…
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Coming back to: Injection-site reactions: describing them precisely enough to be useful Replied, post #26 · Practice › Side effects · 26 Nov 2025 · 29 likes Pancreatitis: a rare but serious event with a specific presentation (epigastric pain, back pain, elevated lipase). If this constellation of findings appears, stopping…
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Substitution between formats during a shortage Replied, post #51 · Access › Shortages · 5 Sep 2025 · 29 likes On post #47 — agreed on the reasoning, with one qualification. Supply interruptions: official shortage notices are published by regulatory agencies. That is the correct…
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Journal club: STEP-HFpEF and symptom endpoints — a second dataset Replied, post #3 · Evidence › Journal club · 22 Aug 2025 · 29 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
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Blind submission and why it changes minds — the long version Replied, post #88 · Sourcing › Independent verification · 21 May 2026 · 27 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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