f.laurent
TL2 Moderator · Graz
Contributes reviews on supplier material. Based in Graz.
Joined 28 September 2024 · last posted 3d
73Posts here
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Second pass at: A pooled estimate that changed when one trial was added Started this topic · Evidence › Meta-analyses · 5 May 2026 · 39 likes On the subject in the title: Second pass at: A pooled estimate that changed when one trial was added Working notes rather than a conclusion. Session topic: SELECT ( N…
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[2026 update] An appeal that failed, and what I would do differently Replied, post #10 · Access › Insurance & coverage · 6 Jun 2025 · 33 likes Tier placement and step therapy: some formularies place a medication on a higher tier or require you to fail cheaper alternatives before approving the one you want.…
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Journal club: SURMOUNT-1, read without the press release Replied, post #55 · Evidence › Journal club · 4 Feb 2025 · 32 likes post #54 is right about the mechanism and I think understates the practical bit. SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0…
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[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #8 · Compounds › Retatrutide · 11 Jul 2025 · 31 likes Coming back to post #6, because the follow-up matters more than the original answer. How to read phase 2 without treating it as phase 3: phase 2 establishes that a dose…
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Biased agonism: a real phenomenon, an over-used explanation Replied, post #95 · Pharmacology › Receptor biology · 14 Mar 2025 · 31 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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Vomiting: when it is expected and when it is a reason to stop — one year on Replied, post #10 · Practice › Side effects · 23 May 2026 · 29 likes Gallbladder complications: rapid weight loss increases the risk of gallstone formation. The mechanism is not specific to this drug class. The risk is greatest in the…
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Badges earned, in order
| Badge | Tier | Granted |
|---|---|---|
| First Reply | bronze | 29 Sep 2024 |
| Basic User | bronze | 2 Oct 2024 |
| Read the Guidelines | bronze | 4 Oct 2024 |
| Welcome | bronze | 12 Oct 2024 |
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| Good Post | silver | 14 Mar 2025 |
| Nice Topic | bronze | 18 Apr 2025 |
| Good Topic | silver | 24 Apr 2025 |
| Anniversary | silver | 28 Sep 2025 |
| De-escalator | gold | 6 Oct 2025 |