f.laurent

TL2 Moderator · Graz

Contributes reviews on supplier material. Based in Graz.

Joined 28 September 2024 · last posted 3d

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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #89 · Practice › Interactions · 25 Jul 2026 · 14 likes Picking up post #86: that is the part I would want checked first. Food interactions: most interactions are absorption interactions. Some medications absorb better with…
Coming back to: Why a preprint's supplementary material is often the best part Replied, post #116 · Evidence › Preprints · 25 Jul 2026 · 5 likes Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the…
Conditions that change the calculus rather than forbidding it Replied, post #32 · Safety › Contraindications · 23 Jul 2026 · 4 likes History of pancreatitis: these compounds can rarely trigger pancreatitis. History of pancreatitis increases relative risk. That is a relative contraindication, not…
What a certificate commits its issuer to Replied, post #65 · Analytics › COA interpretation · 20 Jul 2026 · 8 likes Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin testing all say nothing about whether a solution is sterile. If sterility…
Revisiting: Protein density versus volume when you cannot eat much Replied, post #72 · Nutrition & Training › Protein & intake · 16 Jul 2026 · 1 like Leucine and MPS: leucine stimulates muscle protein synthesis at a threshold of roughly 2 to 3 grams per meal. That influences how much protein per meal matters, but…
Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #52 · Pharmacology › Pharmacokinetics · 16 Jul 2026 · 0 likes On post #48 — agreed on the reasoning, with one qualification. Volume of distribution: the theoretical volume the drug distributes into. For albumin-binding compounds,…
What a reversed-phase purity number actually is Replied, post #55 · Analytics › HPLC & UHPLC · 14 Jul 2026 · 0 likes This follows post #52 rather than contradicting it. Detection wavelength: 214 nm detects the peptide bond and is relatively insensitive to composition. 280 nm detects…
Sleep apnoea improving and the equipment implications Replied, post #14 · Wellbeing › Sleep · 12 Jul 2026 · 16 likes Coming back to post #12, because the follow-up matters more than the original answer. Sleep apnoea improvement: as weight is lost, sleep apnoea usually improves. The…
Pooling trials with different estimands Replied, post #79 · Evidence › Meta-analyses · 7 Jul 2026 · 20 likes Coming back to post #77, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #114 · Sourcing › Logistics · 26 Jun 2026 · 5 likes post #113 is right about the mechanism and I think understates the practical bit. Tracking stops updating: tracking last updated days ago usually means the package is…
Publication patterns in the BPC-157 literature, examined Replied, post #14 · Compounds › Repair & healing peptides · 15 Jun 2026 · 6 likes Why plausible mechanism is not evidence of effect: a mechanism that is chemically or biologically plausible can fail in practice for dozens of reasons —…
Micro-titration: a disputed topic, argued properly — one year on Replied, post #49 · Practice › Dosing & titration · 13 Jun 2026 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…