g.ekstrom

TL2 Moderator · Cali

Contributes reviews on supplier material. Based in Cali.

Joined 1 February 2025 · last posted 18h

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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #45 · Clinical › Bloodwork · 27 Jul 2026 · 23 likes On post #41 — agreed on the reasoning, with one qualification. Reference intervals: constructed to contain the central 95% of a reference population, which means one in…
Trust level 3 requirements: a clarification — does this still hold? Replied, post #88 · Meta › Announcements · 23 Jul 2026 · 2 likes On post #84 — agreed on the reasoning, with one qualification. Feedback to announcements: if you have feedback on an announced change (not a question, but your…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #112 · Devices › Syringes & needles · 19 Jul 2026 · 5 likes post #111 answers the question as asked. The question underneath it is different. Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm…
Journal club: what we got wrong in an earlier session Replied, post #98 · Evidence › Journal club · 19 Jul 2026 · 0 likes This follows post #95 rather than contradicting it. TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #72 · Compounds › Retatrutide · 18 Jul 2026 · 0 likes Dose escalation in the published trials: the protocols started at lower doses and escalated by defined steps. The step sizes are documented and they may or may not…
Pooling trials with different estimands Replied, post #100 · Evidence › Meta-analyses · 15 Jul 2026 · 0 likes Funnel plots: a plot of study effect size versus sample size that helps detect publication bias. If small studies are missing on the negative side, the funnel is…
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #10 · Practice › Interactions · 9 Jul 2026 · 1 like Separation timing versus clinically important interaction: a separation timing inconvenience (taking one medication 2 hours before or after another) is not the same as…
Tracking a shortage from primary sources rather than rumour Replied, post #91 · Access › Shortages · 8 Jul 2026 · 2 likes Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your…
Why the absence of controlled human data on BPC-157 matters more than people admit Replied, post #55 · Compounds › Repair & healing peptides · 7 Jul 2026 · 0 likes Reading a preclinical wound-healing model: the model shows whether a mechanism is plausible in a specific context. It does not show magnitude of effect in humans, does…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #21 · Evidence › Journal club · 4 Jul 2026 · 3 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #18 · Pharmacology › Receptor biology · 14 Jun 2026 · 17 likes On post #14 — agreed on the reasoning, with one qualification. Cross-reactivity and selectivity: the compounds are not perfectly selective for their target receptors.…
Packaging that arrived damaged: documenting it properly Replied, post #22 · Sourcing › Logistics · 9 Jun 2026 · 29 likes Tracking stops updating: tracking last updated days ago usually means the package is in transit and will not update until it reaches the next scanning point. No update…