l.aguirre
TL2 Moderator · Catania
Contributes reviews on supplier material. Based in Catania.
Joined 2 October 2024 · last posted 1d · groups: newcomer-guides
83Posts here
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What a certificate commits its issuer to Replied, post #114 · Analytics › COA interpretation · 27 Jul 2026 · 29 likes Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin testing all say nothing about whether a solution is sterile. If sterility…
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Here for the analytics and not much else Replied, post #84 · Lounge › Introductions · 24 Jul 2026 · 26 likes What to include: your name or handle, how you found the community, what brings you here, maybe something about yourself that seems relevant (clinician, researcher,…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #116 · Sourcing › Independent verification · 23 Jul 2026 · 12 likes Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
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Follow-up: How compounding permissions changed when supply normalised Replied, post #45 · Sourcing › Regulatory · 20 Jul 2026 · 11 likes I read post #43 twice before replying, because I had assumed the opposite. Research-use-only status is a legal classification, not a safety classification. It means the…
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About the Mass spectrometry category Replied, post #8 · Analytics › Mass spectrometry · 16 Jul 2026 · 16 likes post #7 is right about the mechanism and I think understates the practical bit. Mass accuracy is expressed in parts per million. It is the difference between observed…
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Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #75 · Outcomes › Progress reports · 14 Jul 2026 · 7 likes Rate of change: reporting progress as "lost 5 kg in 12 weeks" is more useful than "currently at 82 kg" because the rate tells you whether the change is steady,…
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #94 · Data & Tools › Datasets · 11 Jul 2026 · 0 likes Privacy: if contributing data, only share data you are comfortable making permanent and public. Once posted, data is persistent.
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Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Replied, post #19 · Evidence › Journal club · 6 Jul 2026 · 0 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #20 · Compounds › Retatrutide · 1 Jul 2026 · 7 likes Coming back to post #18, because the follow-up matters more than the original answer. Hepatic effects: glucagon receptor agonism promotes hepatic fat oxidation, which…
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #103 · Evidence › Journal club · 1 Jul 2026 · 0 likes PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy. Non-inferiority for safety was met. The trial was not designed to…
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Journal club: SUSTAIN 6 and its retinopathy signal Started this topic · Evidence › Journal club · 26 Jun 2026 · 0 likes On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited…
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Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #32 · Practice › Reconstitution · 25 Jun 2026 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.