m.duarte

TL2 Moderator · Galway

Contributes reviews on supplier material. Based in Galway.

Joined 29 March 2025 · last posted 4d

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Reference intervals: how they are constructed and why one in twenty flags — does this… Replied, post #21 · Clinical › Bloodwork · 24 Jul 2026 · 12 likes post #20 is right about the mechanism and I think understates the practical bit. Fasting state: some lab tests require fasting; others do not. Lipids on a fasting draw…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #106 · Analytics › Impurities & related substances · 23 Jul 2026 · 1 like I read post #104 twice before replying, because I had assumed the opposite. Aggregates: multiples of the monomer mass. May not elute at all under a standard…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #117 · Sourcing › Independent verification · 23 Jul 2026 · 0 likes Picking up post #114: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
Primary endpoint hierarchies and why order matters — one year on Replied, post #54 · Evidence › Trials · 21 Jul 2026 · 11 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Common supplements people ask about, assessed one at a time Replied, post #36 · Practice › Interactions · 12 Jul 2026 · 22 likes Worth separating two things that post #32 runs together. Separation timing versus clinically important interaction: a separation timing inconvenience (taking one…
About the Mass spectrometry category Replied, post #7 · Analytics › Mass spectrometry · 10 Jul 2026 · 31 likes Worth separating two things that post #3 runs together. What mass accuracy establishes: the measured mass is consistent with a specific composition. What it does not…
How much context is too much context in a first post? Replied, post #39 · Start Here › How to Ask · 7 Jul 2026 · 29 likes Picking up post #36: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #104 · Evidence › Journal club · 2 Jul 2026 · 2 likes I read post #102 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #17 · Compounds › Retatrutide · 28 Jun 2026 · 25 likes Why this subcategory is more cautious than elsewhere: retatrutide is investigational, phase 3 is ongoing, and the heart-rate signal in phase 2 is not negligible.…
Coming back to: Payment method and the leverage it gives you, ranked Replied, post #10 · Sourcing › Payments · 25 Jun 2026 · 20 likes Currency conversion: payment in your local currency often involves a conversion fee. Paying in the supplier's native currency sometimes saves money, sometimes costs…
A pooled estimate that changed when one trial was added Replied, post #14 · Evidence › Meta-analyses · 24 Jun 2026 · 2 likes Publication bias: what did not get published? Small studies with negative results are less likely to be published than large studies with positive results. A forest…
Alcohol: what is documented and what is folklore Replied, post #58 · Practice › Interactions · 15 Jun 2026 · 18 likes Thyroid medications: semaglutide is associated with a slowing of gastric emptying, which might affect thyroid medication absorption if they are taken very close…