o.pasquale
TL1 Member · Dijon, FR
Newer member working through the reference pages before asking anything.
Joined 9 November 2025 · last posted 13h
28Posts here
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Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #44 · Pharmacology › Formulation chemistry · 27 Jul 2026 · 0 likes Buffers and pH: the pH of a solution is buffered to maintain stability. The buffer system (phosphate, Tris, or other) is chosen to keep the solution at the pH where the…
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A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #91 · Practice › Interactions · 22 Jul 2026 · 12 likes post #90 is right about the mechanism and I think understates the practical bit. Food interactions: most interactions are absorption interactions. Some medications…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #58 · Practice › Dosing & titration · 12 Jul 2026 · 0 likes When a dose reduction is the correct response to a side effect: if a side effect is dose-dependent (nausea, constipation, injection discomfort), reducing the dose is a…
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A critique that turned out to be unfair, retracted by its author Replied, post #24 · Evidence › Study critique · 4 Jul 2026 · 5 likes Multiple comparisons: if a paper reports many outcomes, the chance of a spurious association by random chance is real. Pre-specification of primary outcomes matters and…
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Journal club: what we got wrong in an earlier session Replied, post #24 · Evidence › Journal club · 23 Jun 2026 · 0 likes I read post #22 twice before replying, because I had assumed the opposite. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the…
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Follow-up: Reading an interaction checker output critically Replied, post #11 · Practice › Interactions · 19 Jun 2026 · 30 likes Insulin interaction: semaglutide and tirzepatide are not contraindicated with insulin but the combination carries hypoglycemia risk if insulin doses are not adjusted.…
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Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #8 · marked as the solution · Compounds › Cagrilintide & amylin analogues · 13 Jun 2026 · 6 likes The CagriSema phase 2 paper: a fixed combination of the two components in one weekly injection. The trade-off of a fixed combination is that you cannot titrate the…
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Revisiting: Mobile reading experience on long topics Replied, post #8 · Meta › Site feedback · 31 May 2026 · 7 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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Prescription requirements and telehealth models — a second dataset Replied, post #22 · Sourcing › Regulatory · 7 May 2026 · 10 likes Preclinical versus clinical: compounds with strong preclinical data can fail in clinical trials. Compounds with no human data are being used on theoretical grounds. The…
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Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #91 · Lounge › Introductions · 17 Mar 2026 · 0 likes No judgment: people come to this community from all backgrounds and with all motivations. Introductions are for getting to know each other, not for evaluation.
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Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #123 · Compounds › Semaglutide · 19 Feb 2026 · 7 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Comparing my trajectory with the trial curves, carefully — a second dataset Started this topic · Outcomes › Progress reports · 14 Jan 2026 · 47 likes Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather…