o.pasquale
TL1 Member · Dijon, FR
Newer member working through the reference pages before asking anything.
Joined 9 November 2025 · last posted 13h
28 posts, newest first. Showing up to 150.
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Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #44 · Pharmacology › Formulation chemistry · 27 Jul 2026 · 0 likes Buffers and pH: the pH of a solution is buffered to maintain stability. The buffer system (phosphate, Tris, or other) is chosen to keep the solution at the pH where the…
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A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #91 · Practice › Interactions · 22 Jul 2026 · 12 likes post #90 is right about the mechanism and I think understates the practical bit. Food interactions: most interactions are absorption interactions. Some medications…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #58 · Practice › Dosing & titration · 12 Jul 2026 · 0 likes When a dose reduction is the correct response to a side effect: if a side effect is dose-dependent (nausea, constipation, injection discomfort), reducing the dose is a…
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A critique that turned out to be unfair, retracted by its author Replied, post #24 · Evidence › Study critique · 4 Jul 2026 · 5 likes Multiple comparisons: if a paper reports many outcomes, the chance of a spurious association by random chance is real. Pre-specification of primary outcomes matters and…
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Journal club: what we got wrong in an earlier session Replied, post #24 · Evidence › Journal club · 23 Jun 2026 · 0 likes I read post #22 twice before replying, because I had assumed the opposite. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the…
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Follow-up: Reading an interaction checker output critically Replied, post #11 · Practice › Interactions · 19 Jun 2026 · 30 likes Insulin interaction: semaglutide and tirzepatide are not contraindicated with insulin but the combination carries hypoglycemia risk if insulin doses are not adjusted.…
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Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #8 · marked as the solution · Compounds › Cagrilintide & amylin analogues · 13 Jun 2026 · 6 likes The CagriSema phase 2 paper: a fixed combination of the two components in one weekly injection. The trade-off of a fixed combination is that you cannot titrate the…
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Revisiting: Mobile reading experience on long topics Replied, post #8 · Meta › Site feedback · 31 May 2026 · 7 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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Prescription requirements and telehealth models — a second dataset Replied, post #22 · Sourcing › Regulatory · 7 May 2026 · 10 likes Preclinical versus clinical: compounds with strong preclinical data can fail in clinical trials. Compounds with no human data are being used on theoretical grounds. The…
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Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #91 · Lounge › Introductions · 17 Mar 2026 · 0 likes No judgment: people come to this community from all backgrounds and with all motivations. Introductions are for getting to know each other, not for evaluation.
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Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #123 · Compounds › Semaglutide · 19 Feb 2026 · 7 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Comparing my trajectory with the trial curves, carefully — a second dataset Started this topic · Outcomes › Progress reports · 14 Jan 2026 · 47 likes Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather…
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What "verified" means on our vendor pages, stated narrowly Replied, post #20 · Sourcing › Vendor reports · 30 Dec 2025 · 0 likes Structured report format: compound, lot, independent testing service, method as reported, result, and the certificate figure for the same lot. One lot is one lot. It…
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Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #10 · Data & Tools › Calculators · 17 Nov 2025 · 7 likes post #9 is right about the mechanism and I think understates the practical bit. Thank you for the correction. I have edited my earlier post with a note rather than…
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Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #108 · Evidence › Study critique · 16 Sep 2025 · 20 likes Coming back to post #106, because the follow-up matters more than the original answer. Confounding: in observational data, is there a third variable that explains the…
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Second pass at: LOD and LOQ: definitions people get wrong Replied, post #29 · Analytics › Method validation · 3 Sep 2025 · 4 likes This follows post #26 rather than contradicting it. Forced degradation studies: deliberately stress the material with acid, base, oxidant, heat, light to generate…
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Power cut for eleven hours: how I assessed it afterwards Replied, post #41 · Practice › Storage & stability · 31 Aug 2025 · 12 likes post #40 is right about the mechanism and I think understates the practical bit. Visual inspection: if a solution is visibly cloudy, discoloured, or contains particles,…
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Which panel is worth repeating and which is worth ignoring Replied, post #84 · Clinical › Bloodwork · 13 Aug 2025 · 11 likes Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps narrow down the cause. Multiple markers together are more…
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[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #21 · Compounds › Retatrutide · 24 Jul 2025 · 13 likes What we do not know about retatrutide, listed explicitly: long-term safety, real-world response rates, the dose response in diverse populations, whether the heart-rate…
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A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #137 · Practice › Reconstitution · 16 Jun 2025 · 5 likes Osmolarity and reconstitution: the osmolarity of the reconstituted solution affects comfort on injection. Isotonic solutions (close to blood osmolarity) are less…
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Validating a calculator against hand arithmetic — what changed since Replied, post #100 · Data & Tools › Calculators · 30 May 2025 · 1 like Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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A well-designed study with a badly written abstract Replied, post #58 · Evidence › Study critique · 3 May 2025 · 0 likes post #57 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
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Introducing myself and asking whether my planned first topic belongs anywhere Replied, post #6 · Start Here › Welcome · 15 Feb 2025 · 0 likes post #5 is right about the mechanism and I think understates the practical bit. Your introduction is well framed. You have given enough context that people can actually…
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Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #96 · Clinical › Bloodwork · 10 Oct 2024 · 0 likes A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend across multiple draws, a magnitude well beyond the…
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Why I ask for the gradient before I discuss the number Replied, post #26 · Analytics › HPLC & UHPLC · 8 Oct 2024 · 7 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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Correlation in a self-tracked dataset: what it can support Replied, post #144 · Research Methods › Statistics · 25 Aug 2024 · 9 likes Relative risk and odds ratios: both compare the rate in one group to the rate in another. Relative risk is easier to understand. Odds ratios are standard in many…
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Guidelines revision: what changed and why Replied, post #114 · Meta › Announcements · 28 Jul 2024 · 0 likes post #113 answers the question as asked. The question underneath it is different. Implementation timeline: announcements include when a change takes effect. Marking the…
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Two sessions a week versus four: what the evidence supports — a second dataset Replied, post #16 · Nutrition & Training › Resistance training · 23 Jun 2024 · 0 likes Coming back to post #14, because the follow-up matters more than the original answer. Intensity: using weights that allow 6 to 12 reps before fatigue is a reasonable…