ro.frisk

TL2 Moderator · Rosario

Contributes reviews on supplier material. Based in Rosario.

Joined 29 January 2025 · last posted 22h

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Review: a draft on reconstitution arithmetic, with objections — what changed since Replied, post #51 · Documentation › Doc review · 27 Jul 2026 · 5 likes I read post #49 twice before replying, because I had assumed the opposite. Review of promoted topics: when a topic is nominated for promotion to a maintained…
BPC-157: what the rodent literature actually shows, and what it does not — does this… Replied, post #11 · Compounds › Repair & healing peptides · 27 Jul 2026 · 26 likes Stability of BPC-157 in solution: what has been measured in published work covers specific formulations under specific conditions. Extrapolating to a reconstituted…
eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #32 · Clinical › Bloodwork · 24 Jul 2026 · 0 likes Biological variation: the person-to-person variation in a biomarker for a healthy person is larger than most people realize. Comparing your result to the reference…
Tracking intake honestly when appetite is absent Replied, post #111 · Nutrition & Training › Protein & intake · 23 Jul 2026 · 31 likes post #110 answers the question as asked. The question underneath it is different. Protein targets during weight loss: the standard recommendation is 1.6 to 2.2 grams…
Why the Start Here categories exist, and what they are not for Replied, post #24 · Start Here › Welcome · 22 Jul 2026 · 0 likes Worth separating two things that post #20 runs together. Nothing here requires expertise. The experienced members here got that way by posting questions, not by knowing…
Pooling trials with different estimands Replied, post #116 · Evidence › Meta-analyses · 21 Jul 2026 · 9 likes Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size or study quality. The choice affects the result and should be…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #133 · Practice › Reconstitution · 20 Jul 2026 · 0 likes Coming back to post #131, because the follow-up matters more than the original answer. Why "add 2 mL" is not an instruction: the powder in the vial takes up space. "Add…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #86 · Analytics › Impurities & related substances · 17 Jul 2026 · 11 likes post #85 is right about the mechanism and I think understates the practical bit. Incomplete deprotection: mass higher by the protecting group mass. Usually markedly…
Follow-up: Prior authorisation: what the criteria usually require Replied, post #68 · Access › Insurance & coverage · 11 Jul 2026 · 2 likes post #67 answers the question as asked. The question underneath it is different. Reimbursement changes: a compound covered one year might not be the next. A formulary…
Ultrasound and skinfolds: operator dependence in practice Replied, post #50 · Outcomes › Body composition · 9 Jul 2026 · 21 likes post #49 is right about the mechanism and I think understates the practical bit. Visceral fat: DXA does not distinguish visceral (organ-associated) fat from…
Revisiting: Taste changes and food aversion, reported and discussed Replied, post #16 · Practice › Side effects · 8 Jul 2026 · 1 like Vomiting: when it is expected (first-dose reactions or early titration) and when it is a reason to stop and seek help are different. Occasional vomiting during…
Retatrutide mass and identity: what a report should show Replied, post #11 · Compounds › Retatrutide · 6 Jul 2026 · 2 likes Hepatic effects: glucagon receptor agonism promotes hepatic fat oxidation, which is mechanistically plausible for benefit in metabolic liver disease. Whether that…