s.grahame
TL2 Member · Quebec City, CA
Practical questions, practical answers. Not interested in speculation without a source.
Joined 14 December 2024 · last posted 3d
83Posts here
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Comparators chosen for regulatory reasons rather than clinical ones — one year on Started this topic · Evidence › Trials · 22 Mar 2025 · 39 likes Comparators chosen for regulatory reasons rather than clinical ones — one year on — setting out what I have, and where I think it stops being reliable. Session topic:…
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Journal club: STEP 4 and what a withdrawal design can prove Replied, post #45 · Evidence › Journal club · 25 May 2025 · 32 likes Picking up post #42: that is the part I would want checked first. FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease.…
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A supplier who responds to a discrepancy with silence — what changed since Replied, post #80 · Sourcing › Red flags · 13 Jul 2026 · 31 likes Inability to trace lots: if you ask "where was this synthesised, by whom, under what conditions" and cannot get a clear answer, that is a red flag. Traceability is not…
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What a documentation review can and cannot tell you Replied, post #6 · Sourcing › Independent verification · 15 Jun 2025 · 31 likes Service differences on vendor pages: Janoshik and Medutest results are measurements on vials. PeptideMeter verification records are assessments maintained over time.…
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About the COA interpretation category Replied, post #11 · Analytics › COA interpretation · 11 May 2026 · 28 likes Worth separating two things that post #7 runs together. Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin testing all say nothing…
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Revisiting: What pooling buys you and what it destroys Replied, post #69 · Evidence › Meta-analyses · 26 Jun 2026 · 26 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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