s.grahame
TL2 Member · Quebec City, CA
Practical questions, practical answers. Not interested in speculation without a source.
Joined 14 December 2024 · last posted 3d
83Posts here
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Coming back to: A structured critique template this community uses Replied, post #68 · Evidence › Study critique · 25 Jul 2026 · 7 likes On post #64 — agreed on the reasoning, with one qualification. What makes a methodological criticism substantive: it identifies a specific feature of the design that…
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What a reversed-phase purity number actually is Replied, post #81 · Analytics › HPLC & UHPLC · 22 Jul 2026 · 2 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
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Here for the analytics and not much else Replied, post #55 · Lounge › Introductions · 19 Jul 2026 · 6 likes This follows post #52 rather than contradicting it. What to include: your name or handle, how you found the community, what brings you here, maybe something about…
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[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #88 · Access › International · 17 Jul 2026 · 7 likes Language barriers: if you need to communicate with a supplier, clinician, or regulator in a language not your first language, misunderstanding is possible. Clarify when…
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What a reversed-phase purity number actually is Replied, post #62 · Analytics › HPLC & UHPLC · 17 Jul 2026 · 0 likes Method validation is the demonstration that a method can separate the compound from its degradation products and impurities reliably. A method that cannot resolve an…
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Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #76 · Analytics › Home & field testing · 14 Jul 2026 · 5 likes Lateral-flow devices: like a rapid COVID test. They have a reagent strip and produce a colour result. They are quick but not precise and not intended for quantitative…
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A supplier who responds to a discrepancy with silence — what changed since Replied, post #80 · Sourcing › Red flags · 13 Jul 2026 · 31 likes Inability to trace lots: if you ask "where was this synthesised, by whom, under what conditions" and cannot get a clear answer, that is a red flag. Traceability is not…
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Aggregate verification data across the directory, with caveats Replied, post #43 · Sourcing › Independent verification · 12 Jul 2026 · 23 likes Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies…
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Revisiting: Liver enzymes drifting down and what that usually means Replied, post #49 · Clinical › Bloodwork · 27 Jun 2026 · 0 likes Picking up post #46: that is the part I would want checked first. A single value outside interval: usually uninformative on a single draw. What makes a result…
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Revisiting: What pooling buys you and what it destroys Replied, post #69 · Evidence › Meta-analyses · 26 Jun 2026 · 26 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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[2026 update] Regional warehouse stock versus direct despatch Replied, post #101 · Sourcing › Logistics · 14 Jun 2026 · 1 like Insurance and carrier liability: most parcel carriers limit liability. Understanding the limits before choosing a carrier matters if you are shipping expensive material.
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Batch numbers that do not match the vial label Replied, post #21 · Sourcing › Red flags · 27 May 2026 · 19 likes Evasion when asked: if a supplier does not clarify when asked specifically for method details, counter-ion form, or batch origin, that itself is a red flag worth…