v.bergstrom

TL2 Moderator · Rennes

Contributes reviews on supplier material. Based in Rennes.

Joined 21 July 2025 · last posted 2d

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Programming during a large energy deficit Replied, post #50 · Nutrition & Training › Resistance training · 26 Jul 2026 · 7 likes Post-weight-loss training: once weight loss is complete and energy deficit ends, training can shift to building again. The transition from preservation mode to building…
Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #29 · Compounds › Cagrilintide & amylin analogues · 22 Jul 2026 · 5 likes Picking up post #26: that is the part I would want checked first. What is genuinely unknown about long-term amylin agonism: real-world response rates, whether effect is…
Revisiting: Protein density versus volume when you cannot eat much Replied, post #91 · Nutrition & Training › Protein & intake · 22 Jul 2026 · 0 likes Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as solid food. Using both together can help.
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #92 · Evidence › Journal club · 9 Jul 2026 · 32 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
Revisiting: What pooling buys you and what it destroys Replied, post #83 · Evidence › Meta-analyses · 8 Jul 2026 · 18 likes post #82 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
[2026 update] Journal club: what we got wrong in an earlier session Replied, post #4 · Evidence › Journal club · 1 Jul 2026 · 0 likes post #3 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
Why side effects reset at each escalation and that is not a failure Replied, post #3 · Practice › Side effects · 1 Jul 2026 · 17 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #47 · Sourcing › Independent verification · 27 Jun 2026 · 3 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #29 · Analytics › Impurities & related substances · 27 Jun 2026 · 0 likes Incomplete deprotection: mass higher by the protecting group mass. Usually markedly later eluting. A synthesis artifact from incomplete removal of protecting groups.
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #19 · Practice › Dosing & titration · 26 Jun 2026 · 2 likes The four-week escalation interval is a convention from the pivotal trials, not a pharmacological constant. The pharmacological argument is that with a week-long…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #60 · Compounds › Oral incretins · 26 Jun 2026 · 10 likes Worth separating two things that post #56 runs together. PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for…
Second pass at: Programming during a large energy deficit Replied, post #33 · Nutrition & Training › Resistance training · 18 Jun 2026 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…