Compounds · subcategory

Secretagogues & GH axis

Growth-hormone secretagogues and related compounds. Evidence quality here is markedly lower and we say so.

24 topics977 posts4 solved Moderators: KLindqvist, bench_notes About this category

GHRP class CJC-1295 ipamorelin tesamorelin observational data needs a source

24 topics

Topic	Participants	Replies	Views	Activity
Second pass at: Why this subcategory is stricter about sourcing than most observational data ipamorelin tesamorelin needs a source Second pass at: Why this subcategory is stricter about sourcing than most — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-4 ( JAMA ,…	+120	129	61k	11mo
CJC-1295 with and without DAC: what the modification does needs a source tesamorelin CJC-1295 GHRP class On the subject in the title: CJC-1295 with and without DAC: what the modification does Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with SURMOUNT-OSA ( N Engl J Med ,…	+117	123	5.6k	22h
Secretagogues and glucose tolerance: the mechanistic concern CJC-1295 tesamorelin observational data needs a source On the subject in the title: Secretagogues and glucose tolerance: the mechanistic concern Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+64	70	52k	17d
Revisiting: What a well-designed human trial of a secretagogue would look like CJC-1295 observational data needs a source GHRP class On the subject in the title: Revisiting: What a well-designed human trial of a secretagogue would look like Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it…	+69	74	25k	18mo
Reading a rodent study on a secretagogue without over-extrapolating — the long version observational data tesamorelin ipamorelin needs a source Reading a rodent study on a secretagogue without over-extrapolating — the long version — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support…	+59	66	30k	4h
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence CJC-1295 needs a source tesamorelin observational data Posting this under the heading it deserves: Tesamorelin has an approved indication — what that changes about the evidence Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with…	+63	68	18k	14mo
Reading a rodent study on a secretagogue without over-extrapolating observational data GHRP class CJC-1295 needs a source Closed Posting this under the heading it deserves: Reading a rodent study on a secretagogue without over-extrapolating Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of…	+50	54	32k	10mo
Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset GHRP class ipamorelin tesamorelin Under review The question in the title: Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N…	+60	64	25k	15mo
IGF-1 as a surrogate endpoint and its limitations — the long version CJC-1295 observational data ipamorelin needs a source Solved Closed On the subject in the title: IGF-1 as a surrogate endpoint and its limitations — the long version Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of a claim I do…	+14	18	53k	12mo
Ipamorelin selectivity claims and where they came from GHRP class tesamorelin ipamorelin Closed Ipamorelin selectivity claims and where they came from — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do not…	+51	56	8.8k	12mo
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion CJC-1295 observational data ipamorelin needs a source Solved On the subject in the title: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of…	+47	53	6.9k	2h
Why this subcategory is stricter about sourcing than most observational data tesamorelin needs a source GHRP class Wiki Asking directly, because I could not find a straight answer: Why this subcategory is stricter about sourcing than most Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+48	52	617	21d
IGF-1 as a surrogate endpoint and its limitations GHRP class needs a source observational data tesamorelin IGF-1 as a surrogate endpoint and its limitations Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I do not…	+5	9	35k	4mo
Follow-up: Evidence quality in the secretagogue literature: an honest assessment CJC-1295 ipamorelin tesamorelin needs a source On the subject in the title: Evidence quality in the secretagogue literature: an honest assessment Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with LEADER ( N Engl J Med…	+20	24	18k	4mo
Secretagogues and glucose tolerance: the mechanistic concern — what changed since GHRP class ipamorelin CJC-1295 observational data Wiki Closed Secretagogues and glucose tolerance: the mechanistic concern — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021)…	+2	6	31k	2mo
Tesamorelin has an approved indication — what that changes about the evidence observational data tesamorelin GHRP class CJC-1295 Tesamorelin has an approved indication — what that changes about the evidence — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-1 ( N Engl J…	+23	27	3.4k	1d
Ipamorelin selectivity claims and where they came from — a second dataset CJC-1295 GHRP class tesamorelin ipamorelin Posting this under the heading it deserves: Ipamorelin selectivity claims and where they came from — a second dataset Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021)…		2	27k	14mo
Evidence quality in the secretagogue literature: an honest assessment ipamorelin observational data GHRP class tesamorelin Solved Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with STEP…		2	25k	9d
[2026 update] Evidence quality in the secretagogue literature: an honest assessment CJC-1295 GHRP class tesamorelin Closed Posting this under the heading it deserves: Evidence quality in the secretagogue literature: an honest assessment Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…	+14	18	3.1k	6mo
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion GHRP class ipamorelin CJC-1295 needs a source Closed GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021)…	+9	13	249	17mo
Why pulsatile secretion matters for interpreting secretagogue claims CJC-1295 GHRP class tesamorelin Why pulsatile secretion matters for interpreting secretagogue claims — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited…	+5	9	1.6k	15h
What a well-designed human trial of a secretagogue would look like GHRP class ipamorelin CJC-1295 tesamorelin Solved What a well-designed human trial of a secretagogue would look like I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited…		2	7.2k	18mo
About the Secretagogues & GH axis category GHRP class CJC-1295 ipamorelin Pinned Wiki Closed Growth-hormone secretagogues and related compounds. Evidence quality here is markedly lower and we say so. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+6	10	1.1k	14mo
CJC-1295 with and without DAC: what the modification does — what changed since GHRP class observational data CJC-1295 tesamorelin CJC-1295 with and without DAC: what the modification does — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024)…		4	5.1k	7mo

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