20 categories

Pharmacology

Receptor biology, pharmacokinetics and formulation chemistry — the mechanistic layer under everything else.

50 topics2,108 posts5 solved Moderators: dr_okonkwo, KLindqvist About this category

Receptor biology 18 Pharmacokinetics 16 Formulation chemistry 16

50 topics · page 2 of 2

Topic	Participants	Replies	Views	Activity
GIP receptor agonism and the argument about direction Pharmacology › Receptor biology tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise…		2	867	10mo
Vagal afferents and the gut-brain pathway — one year on Pharmacology › Receptor biology amylin analogues long read semaglutide retatrutide Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…		2	136	11mo
Second pass at: Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Closed Second pass at: Isotonicity and what happens when you get it wrong — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…	+1	5	2.6k	11mo
Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics missed dose worked example semaglutide Wiki Posting this under the heading it deserves: Subcutaneous absorption kinetics and site differences Everything below is what sits behind that. I would like to understand what this number means before I repeat…	+15	19	3.9k	12mo
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+5	9	44k	13mo
[2026 update] Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide worked example Solved On the subject in the title: Clearance pathways and what renal impairment changes Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front…	+63	69	50k	13mo
Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics semaglutide liraglutide tirzepatide Wiki Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+115	130	44k	13mo
Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics semaglutide liraglutide worked example tirzepatide Albumin binding and how it produces a long half-life — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere. A…	+38	44	6.6k	14mo
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+3	7	36k	14mo
Excipient function in a licensed injectable — the long version Pharmacology › Formulation chemistry sterile water storage bacteriostatic water Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. Working through the identity arithmetic and I would like…		2	100	15mo
Why appetite effects are mostly central Pharmacology › Receptor biology amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three replies will…		2	56k	16mo
Preservatives: function, testing, and limits Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked. tirzepatide has a…	+23	27	3.7k	16mo
Biased agonism: a real phenomenon, an over-used explanation Pharmacology › Receptor biology semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. A documentation question rather than an analytical one. I…	+130	135	23k	16mo
Second pass at: Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics missed dose worked example semaglutide Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. I would like to understand what this number means…	+7	11	31k	17mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…	+49	56	47k	17mo
Coming back to: Adsorption to container surfaces and to plastics Pharmacology › Formulation chemistry bacteriostatic water counter-ion content storage sterile water Adsorption to container surfaces and to plastics — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise be.…		2	459	17mo
Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry sterile water counter-ion content storage On the subject in the title: Isotonicity and what happens when you get it wrong Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise be.…	+27	31	11k	18mo
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+151	163	9.7k	21mo
Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+11	15	51k	21mo
Second pass at: Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water Wiki Second pass at: Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I…	+24	28	1.5k	21mo