20 categories

Pharmacology

Receptor biology, pharmacokinetics and formulation chemistry — the mechanistic layer under everything else.

50 topics2,108 posts5 solved Moderators: dr_okonkwo, KLindqvist About this category

Receptor biology 18 Pharmacokinetics 16 Formulation chemistry 16

50 topics

Topic	Participants	Replies	Views	Activity
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+151	163	9.7k	21mo
Biased agonism: a real phenomenon, an over-used explanation Pharmacology › Receptor biology semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. A documentation question rather than an analytical one. I…	+130	135	23k	16mo
Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics semaglutide liraglutide tirzepatide Wiki Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+115	130	44k	13mo
Coming back to: Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics missed dose semaglutide worked example Closed Posting this under the heading it deserves: Washout: how long is long enough, and for what purpose Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+128	139	3k	3mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A documentation question rather than an analytical one. I have a certificate in front of me that reports a…	+86	90	61k	9mo
Half-life, steady state, and accumulation worked through — a second dataset Pharmacology › Pharmacokinetics semaglutide worked example liraglutide Half-life, steady state, and accumulation worked through — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+110	126	14k	4mo
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+104	110	16k	2d
[2026 update] Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide worked example Solved On the subject in the title: Clearance pathways and what renal impairment changes Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front…	+63	69	50k	13mo
GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+90	98	30k	22h
Biased agonism: a real phenomenon, an over-used explanation — what changed since Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…	+49	56	47k	17mo
Lyophilisation and why the cake looks the way it does Pharmacology › Formulation chemistry sterile water bacteriostatic water storage cloudy or discoloured solution Posting this under the heading it deserves: Lyophilisation and why the cake looks the way it does Everything below is what sits behind that. I would like to understand what this number means before I repeat…	+33	37	60k	6mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+73	78	3.5k	2mo
Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics semaglutide missed dose worked example Closed Washout: how long is long enough, and for what purpose — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…	+63	70	13k	10mo
Peak-to-trough ratio at steady state for a weekly agent Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose Solved On the subject in the title: Peak-to-trough ratio at steady state for a weekly agent Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…	+58	64	9.7k	2mo
Revisiting: GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+61	66	15k	8mo
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+52	57	25k	just now
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means…	+57	61	708	1d
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+38	43	29k	13h
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Pharmacology › Receptor biology retatrutide amylin analogues semaglutide Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. I would like to understand…	+57	63	1k	6mo
Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+11	15	51k	21mo
Why appetite effects are mostly central Pharmacology › Receptor biology amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three replies will…		2	56k	16mo
Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+11	15	43k	2mo
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+5	9	44k	13mo
Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry sterile water counter-ion content storage On the subject in the title: Isotonicity and what happens when you get it wrong Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise be.…	+27	31	11k	18mo
Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics semaglutide liraglutide worked example tirzepatide Albumin binding and how it produces a long half-life — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere. A…	+38	44	6.6k	14mo
GLP-1 receptor distribution: central and peripheral — one year on Pharmacology › Receptor biology long read retatrutide amylin analogues semaglutide GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+7	11	43k	3mo
Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate…	+11	15	34k	20h
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+3	7	36k	14mo
Second pass at: Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics missed dose worked example semaglutide Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. I would like to understand what this number means…	+7	11	31k	17mo

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