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Devices · Syringes & needles · continued

Follow-up: Dead volume across syringe and needle combinations posts 91–99

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

ZO
z.okonkwoTL2 Moderator30 Dec 2024#91
t.ibarra, post #51: Picking up post #48: that is the part I would want checked first. Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose. Go to post

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

16 likes in reply to #51 19mo
SS
system_suitabilityTL3Analytical chemist1 Jan 2025#92

I read post #90 twice before replying, because I had assumed the opposite.

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

31 likes 19mo
NO
n.okwuosaTL2 Moderator3 Jan 2025#93

post #92 is right about the mechanism and I think understates the practical bit.

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

0 likes 19mo
PI
p.iyer_pharmdTL3Pharmacist5 Jan 2025#94

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

3 likes 19mo
ES
e.steinerTL2 Moderator6 Jan 2025#95
a.zamora, post #44: Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses. Go to post

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

23 likes in reply to #44 19mo
TP
tracked_parcelTL2Regular8 Jan 2025#96

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

0 likes 19mo
NI
n.ibarraTL2 Moderator10 Jan 2025#97

post #96 answers the question as asked. The question underneath it is different.

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

1 like 19mo
KO
k.otieno_statsTL3Statistician11 Jan 2025 · edited#98
s.grahame, post #23: Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

On post #94 — agreed on the reasoning, with one qualification.

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

6 likes in reply to #23 18mo
SR
s.rasmussenTL2 Moderator13 Jan 2025#99

This follows post #96 rather than contradicting it.

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

7 likes 18mo

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