Evidence · Journal club · continued

Follow-up: Journal club: orforglipron phase 2 and the non-peptide question posts 91–92

Evidence › Journal club randomised trial risk of bias effect size number needed to treat

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

a.asanteTL2 Moderator9 Sep 2025#91

SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower and more variable than injectable.

5 likes 11mo

l.oseiTL2 Moderator10 Sep 2025#92

Picking up post #89: that is the part I would want checked first.

Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your population to apply the results? (4) What was the absolute effect, not just the relative one? (5) What are the two strongest criticisms available?

0 likes 11mo

This topic was referenced in

Journal club: STEP 1 and the treatment-policy estimandEvidence › Journal club · 3 replies
Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold?Evidence › Journal club · 3 replies

Suggested topics

Topic	Participants	Replies	Views	Activity
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club risk of bias number needed to treat randomised trial Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+118	132	12k	15mo
Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club estimand number needed to treat journal club randomised trial Solved Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+7	11	33k	7mo
Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? Evidence › Journal club journal club effect size number needed to treat Solved The question in the title: Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 (…		2	15k	10mo
Journal club: the CagriSema phase 2 combination paper — a second dataset Evidence › Journal club journal club estimand effect size Solved Journal club: the CagriSema phase 2 combination paper — a second dataset — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a…	+74	79	2.3k	13mo
Journal club: SURMOUNT-4 and continuation versus withdrawal Evidence › Journal club journal club number needed to treat effect size Journal club: SURMOUNT-4 and continuation versus withdrawal — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not…	+32	36	31k	3mo

Related topics — sharing the tags randomised trial, risk of bias, effect size

Topic	Participants	Replies	Views	Activity
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost…	+109	125	42k	10h
Blinding yourself: practical methods and their limits — the long version Research Methods › N-of-1 designs worked example effect size confounding data table Blinding yourself: practical methods and their limits — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024)…	+7	11	1.8k	22h
Designing a personal experiment that could change your mind Research Methods › N-of-1 designs confounding worked example data table effect size Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. Session topic: STEP 8 ( JAMA , 2022). Please read it before…	+2	6	695	6mo
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Compounds › Oral incretins PIONEER programme SOUL trial randomised trial orforglipron Solved PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please…	+25	29	22k	1d
Selection into a registry and what it does to the estimate Evidence › Study critique risk of bias disputed observational data Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…		2	55k	7mo