Tags · Compound

semaglutide

GLP-1 receptor agonist; the compound with the largest published human dataset in this class.

80 topics 17 solved Synonyms: sema Group: Compound

Pharmacology 29 Practice 28 Compounds 23

Related in this group: tirzepatide · retatrutide · cagrilintide · cagrisema · liraglutide · dulaglutide · exenatide · orforglipron · oral semaglutide · survodutide · mazdutide · amylin analogues

80 topics · page 2 of 3

Topic	Participants	Replies	Views	Activity
Semaglutide half-life: where the 165 to 184 hour figure comes from Compounds › Semaglutide semaglutide effect size randomised trial type 2 diabetes Wiki Semaglutide half-life: where the 165 to 184 hour figure comes from — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with STEP 4 ( JAMA , 2021) and…	+128	145	3k	4mo
Splitting a weekly dose in two: the pharmacokinetic argument against Practice › Dosing & titration titration tirzepatide semaglutide missed dose Splitting a weekly dose in two: the pharmacokinetic argument against — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I…	+24	28	51k	5mo
How the published trials escalated, tabulated side by side Practice › Dosing & titration worked example semaglutide titration dose reduction Solved Closed The question in the title: How the published trials escalated, tabulated side by side I will give what I have already checked below so nobody repeats it. A question about technique rather than about dose. I…	+4	8	4.2k	5mo
The most common factual error about semaglutide on the internet — what changed since Compounds › Semaglutide effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 1 ( N…	+42	46	1.7k	5mo
The lowest dose that does anything: is that a real question? Practice › Dosing & titration dose reduction worked example missed dose titration Asking directly, because I could not find a straight answer: The lowest dose that does anything: is that a real question? I have read the maintained page on this and I still have a gap, so I am asking rather…	+100	111	9.1k	5mo
Why semaglutide's albumin binding is the whole reason weekly dosing works Compounds › Semaglutide STEP programme SELECT trial randomised trial effect size Solved Closed Asking directly, because I could not find a straight answer: Why semaglutide's albumin binding is the whole reason weekly dosing works Session topic: SELECT ( N Engl J Med , 2023). Please read it before…		2	63k	5mo
Revisiting: What SELECT changed about how semaglutide is discussed, and what it did not Compounds › Semaglutide semaglutide effect size STEP programme randomised trial Solved Revisiting: What SELECT changed about how semaglutide is discussed, and what it did not Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J…		2	1.9k	5mo
Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration tirzepatide dose reduction titration semaglutide Solved Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…	+124	133	11k	5mo
Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works Compounds › Semaglutide SELECT trial STEP programme effect size randomised trial Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet ,…		2	39k	6mo
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Pharmacology › Receptor biology retatrutide amylin analogues semaglutide Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. I would like to understand…	+57	63	1k	6mo
Follow-up: Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+5	9	21k	7mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since Compounds › Semaglutide semaglutide SELECT trial type 2 diabetes STEP programme Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA ,…	+6	10	6.1k	8mo
[2026 update] What steady state means for the decision to escalate Practice › Dosing & titration tirzepatide worked example semaglutide missed dose The question in the title: What steady state means for the decision to escalate I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still have a…	+127	137	32k	8mo
About the Pharmacokinetics category Pharmacology › Pharmacokinetics semaglutide tirzepatide liraglutide Pinned Wiki Half-life, accumulation, steady state, albumin binding, and why weekly dosing works. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	32k	8mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A documentation question rather than an analytical one. I have a certificate in front of me that reports a…	+86	90	61k	9mo
Amylin receptor signalling and satiety Pharmacology › Receptor biology tirzepatide semaglutide amylin analogues Wiki Amylin receptor signalling and satiety Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a certificate in front…	+22	26	1.8k	9mo
Dose numbers across compounds are not on the same scale Practice › Dosing & titration titration worked example tirzepatide missed dose Dose numbers across compounds are not on the same scale — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I am asking…		2	1.6k	9mo
Follow-up: Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration dose reduction worked example tirzepatide missed dose Solved Asking directly, because I could not find a straight answer: Why "dose equivalence" between different incretin analogues is a weak concept Reporting something rather than asking about it, in case the pattern…	+7	11	26k	9mo
Follow-up: Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics semaglutide liraglutide worked example Subcutaneous absorption kinetics and site differences — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere. A…		4	9.9k	10mo
Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics semaglutide missed dose worked example Closed Washout: how long is long enough, and for what purpose — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…	+63	70	13k	10mo
GIP receptor agonism and the argument about direction Pharmacology › Receptor biology tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise…		2	867	10mo
Escalating every six weeks instead of four: what I observed over eight months — one year on Practice › Dosing & titration missed dose semaglutide dose reduction titration On the subject in the title: Escalating every six weeks instead of four: what I observed over eight months — one year on Working notes rather than a conclusion. I have read the maintained page on this and I…	+55	59	9.1k	10mo
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Practice › Dosing & titration missed dose tirzepatide dose reduction titration Solved Asking directly, because I could not find a straight answer: Reaching a dose and staying there for a year: a longitudinal note — does this still hold? I have read the maintained page on this and I still have…	+35	39	547	11mo
Vagal afferents and the gut-brain pathway — one year on Pharmacology › Receptor biology amylin analogues long read semaglutide retatrutide Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…		2	136	11mo
About the Semaglutide category Compounds › Semaglutide semaglutide STEP programme SELECT trial Pinned Wiki Closed GLP-1 receptor agonist. Dosing, published trial data, tolerability, and formulation questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	4.2k	11mo
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide half-life: where the 165 to 184 hour figure comes from Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…	+112	119	3.3k	11mo
Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics missed dose worked example semaglutide Wiki Posting this under the heading it deserves: Subcutaneous absorption kinetics and site differences Everything below is what sits behind that. I would like to understand what this number means before I repeat…	+15	19	3.9k	12mo
Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration dose reduction missed dose semaglutide Holding a dose indefinitely: is there a documented downside? — that is the question, and I have not found it answered plainly anywhere I have looked. A question about technique rather than about dose. I have…	+28	32	57k	12mo
Titrating on tolerability rather than on the calendar Practice › Dosing & titration dose reduction tirzepatide worked example missed dose On the subject in the title: Titrating on tolerability rather than on the calendar Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking rather…		2	31k	13mo
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+5	9	44k	13mo