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Tags · Compound

tirzepatide

Dual GIP and GLP-1 receptor agonist.

73 topics 20 solved Synonyms: tirz, tzp Group: Compound

Practice 26 Compounds 24 Pharmacology 23

Related in this group: semaglutide · retatrutide · cagrilintide · cagrisema · liraglutide · dulaglutide · exenatide · orforglipron · oral semaglutide · survodutide · mazdutide · amylin analogues

73 topics · page 3 of 3

Topic	Participants	Replies	Views	Activity
Biased agonism: a real phenomenon, an over-used explanation Pharmacology › Receptor biology semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. A documentation question rather than an analytical one. I…	+130	135	23k	16mo
Titrating on tolerability rather than on the calendar — the long version Practice › Dosing & titration worked example missed dose titration tirzepatide Titrating on tolerability rather than on the calendar — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in…		2	7.7k	17mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…	+49	56	47k	17mo
Revisiting: Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration titration tirzepatide worked example missed dose Solved The question in the title: Revisiting: Holding a dose indefinitely: is there a documented downside? I will give what I have already checked below so nobody repeats it. A question about technique rather than…	+26	30	4.5k	18mo
SURPASS-2 and the comparator dose question that will not go away Compounds › Tirzepatide SURPASS programme randomised trial effect size SURMOUNT programme SURPASS-2 and the comparator dose question that will not go away — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before…	+101	111	1.5k	18mo
Tirzepatide storage and stability: what is published versus what is assumed — does this still hold? Compounds › Tirzepatide tirzepatide SURPASS programme effect size The question in the title: Tirzepatide storage and stability: what is published versus what is assumed — does this still hold? I will give what I have already checked below so nobody repeats it. Comparing…	+15	19	930	18mo
Follow-up: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration tirzepatide dose reduction worked example missed dose Wiki Where the four-week escalation interval comes from, and what it is not Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still…	+131	147	47k	18mo
Follow-up: Tirzepatide's shorter half-life and its one practical consequence Compounds › Tirzepatide tirzepatide SURPASS programme SURMOUNT programme effect size Solved Tirzepatide's shorter half-life and its one practical consequence Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of…	+130	137	11k	19mo
Follow-up: Escalating every six weeks instead of four: what I observed over eight months Practice › Dosing & titration titration worked example tirzepatide dose reduction Escalating every six weeks instead of four: what I observed over eight months — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have…		4	164	20mo
Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology semaglutide retatrutide tirzepatide Pinned On the subject in the title: Glucagon receptor agonism in a weight-loss compound Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise…		2	5.1k	20mo
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+151	163	9.7k	21mo
[2026 update] Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide effect size SURMOUNT programme tirzepatide randomised trial Comparing tirzepatide and semaglutide is harder than the tables suggest Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-1…		2	23k	21mo
Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration missed dose semaglutide tirzepatide titration Solved On the subject in the title: Where the four-week escalation interval comes from, and what it is not Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I…	+56	60	21k	2y