Norrington
TL3 Regular · Klaipėda, LT
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 6 December 2024 · last posted 2d · groups: journal-club
143Posts here
4Topics
1Solutions
508Likes received
341Likes given
32Badges
229Days visited
2.5kPosts read
Stated areas
Recent activity
Full stream-
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #81 · Outcomes › Progress reports · 26 Jul 2026 · 1 like On post #77 — agreed on the reasoning, with one qualification. Menstrual cycle: for people who menstruate, weight can shift by several pounds across the cycle due to…
-
Why the Start Here categories exist, and what they are not for Replied, post #37 · Start Here › Welcome · 25 Jul 2026 · 2 likes Welcome. The orientation materials are pinned at the top of this category and they take about an hour. They answer most of the questions a new member has and they save…
-
Coming back to: Preparing for an appointment: one page, three questions Replied, post #48 · Clinical › Prescriber conversations · 25 Jul 2026 · 1 like Asking about monitoring: understand what lab work will be done, how often, and what you will be monitored for. A plan is better than ad-hoc monitoring.
-
Deletion sequences: expected mass shifts by residue — the long version Replied, post #22 · Analytics › Impurities & related substances · 24 Jul 2026 · 2 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
-
Request: a per-category review queue Replied, post #127 · Meta › Feature requests · 24 Jul 2026 · 0 likes post #126 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
-
Which categories are strict and which are relaxed, honestly Replied, post #28 · Start Here › Welcome · 19 Jul 2026 · 4 likes On the reading order question specifically: start with the how-to-ask materials in this category, then read the one to three subcategories where your main questions…
-
Pooling trials with different estimands Replied, post #105 · Evidence › Meta-analyses · 17 Jul 2026 · 4 likes Number needed to treat from a meta-analysis: can be computed from the pooled estimate if the baseline risk is specified. More interpretable than pooled relative effects.
-
Tracking intake honestly when appetite is absent Replied, post #102 · Nutrition & Training › Protein & intake · 17 Jul 2026 · 9 likes This follows post #99 rather than contradicting it. Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as…
-
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #104 · Compounds › Semaglutide · 14 Jul 2026 · 6 likes The opalescent appearance in semaglutide solutions is occasionally noted and the mechanism is unclear. It does not appear to correlate with product failure in practice.…
-
Which categories are strict and which are relaxed, honestly Replied, post #11 · Start Here › Welcome · 13 Jul 2026 · 0 likes The FAQ link in the sidebar is maintained and worth ten hours of forum browsing. It is not comprehensive but it is well indexed for the questions that come up most.
-
Follow-up: How compounding permissions changed when supply normalised Replied, post #8 · Sourcing › Regulatory · 10 Jul 2026 · 5 likes Picking up post #5: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
-
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #34 · Pharmacology › Receptor biology · 3 Jul 2026 · 14 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Maintains 1 document
- SURMOUNT-1 — trial digestReview due 21 May 2027