c.bakker

TL2 Moderator · Basel

Contributes reviews on supplier material. Based in Basel.

Joined 9 January 2025 · last posted 2d

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Revisiting: What pooling buys you and what it destroys Replied, post #107 · Evidence › Meta-analyses · 26 Jul 2026 · 24 likes Inclusion and exclusion criteria: a meta-analysis is only as good as its inclusion criteria. If the criteria are too broad, apples and oranges get pooled. If they are…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #91 · Wellbeing › Sleep · 21 Jul 2026 · 0 likes Worth separating two things that post #87 runs together. Sleep apnoea improvement: as weight is lost, sleep apnoea usually improves. The timeframe is weeks to months,…
What a certificate commits its issuer to Replied, post #59 · Analytics › COA interpretation · 19 Jul 2026 · 17 likes Purity and content are different measurements: purity tells you what proportion of the detected material is the intended species. Content tells you how much of the…
[2026 update] Waist circumference technique and its repeatability Replied, post #25 · Outcomes › Progress reports · 16 Jul 2026 · 5 likes Protein intake and resistance training: both self-reported and therefore optimistic in most reports. Recording them anyway creates a record you can look back on.
What a reversed-phase purity number actually is Replied, post #49 · Analytics › HPLC & UHPLC · 13 Jul 2026 · 19 likes Method validation is the demonstration that a method can separate the compound from its degradation products and impurities reliably. A method that cannot resolve an…
Publication patterns in the BPC-157 literature, examined Replied, post #30 · Compounds › Repair & healing peptides · 7 Jul 2026 · 0 likes Oral versus injected administration claims for BPC-157: the preclinical work studied injection. Oral claims are common in supplier marketing and poorly supported by…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #94 · Compounds › Semaglutide · 7 Jul 2026 · 12 likes Approved indications differ by jurisdiction and change. As of mid-2026 the weight-management indication is approved in many European jurisdictions but not all, and…
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #39 · Analytics › Method validation · 5 Jul 2026 · 1 like System suitability: injections run at the start of a batch to establish that the instrument and column are performing. Acceptance criteria typically include replicate…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #28 · Compounds › Retatrutide · 30 Jun 2026 · 4 likes Phase 2 sample sizes are not adequate for safety characterisation of a novel triple agonist. Phase 3 is where that question gets answered. Using phase 2 results to make…
Secretagogues and glucose tolerance: the mechanistic concern Replied, post #52 · Compounds › Secretagogues & GH axis · 27 Jun 2026 · 15 likes post #51 is right about the mechanism and I think understates the practical bit. CJC-1295 with and without DAC: the version with a drug affinity complex binds albumin…
Submitting a sample: the process end to end Replied, post #27 · Sourcing › Independent verification · 20 Jun 2026 · 1 like Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
Manufacturer assistance programmes and their eligibility rules Replied, post #34 · Access › Pricing · 15 Jun 2026 · 2 likes Biosimilars and future generics: as patents expire, biosimilar and generic versions might become available and prices might fall. That has already happened for some…