e.kuipers

TL2 Moderator · Mombasa

Contributes reviews on supplier material. Based in Mombasa.

Joined 25 September 2025 · last posted 3d

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Deletion sequences: expected mass shifts by residue — the long version Replied, post #23 · Analytics › Impurities & related substances · 25 Jul 2026 · 9 likes Picking up post #20: that is the part I would want checked first. Related substances: compounds chemically related to the target peptide but not the target peptide…
Coming back to: Preparing for an appointment: one page, three questions Replied, post #47 · Clinical › Prescriber conversations · 25 Jul 2026 · 7 likes Preparing for an appointment: bring recent bloodwork, a list of current medications with doses and timing, and any questions written out. Written questions get better…
Request: a per-category review queue Replied, post #128 · Meta › Feature requests · 24 Jul 2026 · 0 likes On post #124 — agreed on the reasoning, with one qualification. Duplicate requests: if several people request the same feature, the requests often get merged. Check…
Which categories are strict and which are relaxed, honestly Replied, post #27 · Start Here › Welcome · 18 Jul 2026 · 12 likes I read post #25 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #103 · Compounds › Semaglutide · 13 Jul 2026 · 16 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Follow-up: How compounding permissions changed when supply normalised Replied, post #7 · Sourcing › Regulatory · 10 Jul 2026 · 14 likes Regulatory positions change: a compound's status today might differ from its status a year from now. Citing a regulatory position is worth doing only with a date…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #90 · Evidence › Journal club · 8 Jul 2026 · 9 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Trust level 3 requirements: a clarification — does this still hold? Replied, post #78 · Meta › Announcements · 7 Jul 2026 · 17 likes Notifications: watching this subcategory means you receive notifications when announcements are posted. Useful if you want to stay current.
How shortages have affected compounding permissions Replied, post #7 · Access › Shortages · 30 Jun 2026 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #23 · Practice › Dosing & titration · 28 Jun 2026 · 3 likes Steady state means the plasma concentration is stable from dose to dose. That happens around 4 to 5 half-lives. Before that, the concentration is rising with each dose.…
Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #88 · Sourcing › Vendor reports · 21 Jun 2026 · 0 likes Date the report: when the analysis was done matters. Material can degrade in storage. A report from two years ago is still useful but is not evidence about the current…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #45 · Evidence › Journal club · 19 Jun 2026 · 20 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…