i.guerrero

TL2 Moderator · Lagos

Contributes reviews on supplier material. Based in Lagos.

Joined 18 April 2025 · last posted 9h

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Adolescents: a distinct evidence base Replied, post #4 · Clinical › Special populations · 28 Jul 2026 · 25 likes Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar…
Reading a home test result without over-claiming Replied, post #137 · Analytics › Home & field testing · 27 Jul 2026 · 12 likes Precision of home tests: most consumer-accessible devices are not precise to the level people want ("is this 99% pure or 97% pure"). They give a yes/no or a rough…
What is genuinely unknown about long-term amylin agonism Replied, post #72 · Compounds › Cagrilintide & amylin analogues · 22 Jul 2026 · 2 likes Gastric emptying: both amylin and GLP-1 slow it, through partly overlapping but distinct mechanisms. Whether the slowing at a higher magnitude produces disproportionate…
Coming back to: Why a preprint's supplementary material is often the best part Replied, post #89 · Evidence › Preprints · 26 Jun 2026 · 5 likes post #88 answers the question as asked. The question underneath it is different. Always label it as a preprint in any discussion. A preprint is not a published trial…
A critique that turned out to be unfair, retracted by its author Replied, post #17 · Evidence › Study critique · 23 Jun 2026 · 0 likes What makes a methodological criticism substantive: it identifies a specific feature of the design that materially affects what the paper can conclude. "Small sample…
Primary endpoint hierarchies and why order matters — one year on Replied, post #20 · Evidence › Trials · 19 Jun 2026 · 1 like post #19 is right about the mechanism and I think understates the practical bit. Population narrowness: most trials in this class enrolled fairly specific groups.…
Injecting into an area that has become firm: why not to Replied, post #73 · Practice › Administration · 14 Jun 2026 · 7 likes post #72 answers the question as asked. The question underneath it is different. Drawing up with one needle and injecting with another: a reasonable practice if you…
Coming back to: Time to steady state after a dose increase Replied, post #64 · Pharmacology › Pharmacokinetics · 29 May 2026 · 10 likes Individual variation: people vary in how quickly they absorb, distribute, metabolise, and excrete these compounds. That variation is partly genetic and partly due to…
Fasting versus non-fasting and which tests care Replied, post #34 · Clinical › Bloodwork · 23 May 2026 · 0 likes Lipid panel interpretation: total, LDL, HDL, triglycerides all on one panel. Reading them together is more informative than reading one value in isolation. An elevated…
A payment that went through twice: how it was resolved Replied, post #25 · Sourcing › Payments · 23 Apr 2026 · 3 likes Cryptocurrency for payment: offers less fraud protection than credit cards and is final like bank transfer. Advantage: no geographic restrictions and no intermediary…
Anaesthesia and elective surgery: the aspiration question Replied, post #89 · Practice › Interactions · 17 Apr 2026 · 31 likes Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and…
[2026 update] Does a peptide degrade silently, with no visual change? Replied, post #42 · Practice › Storage & stability · 3 Apr 2026 · 24 likes Worth separating two things that post #38 runs together. Published stability data applies specifically to the formulation studied, under the specific conditions stated.…