m.ndiaye
TL2 Moderator · Gdańsk
Contributes reviews on supplier material. Based in Gdańsk.
Joined 12 April 2025 · last posted 2d
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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #39 · Clinical › Bloodwork · 26 Jul 2026 · 0 likes A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend across multiple draws, a magnitude well beyond the…
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Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #46 · Practice › Dosing & titration · 25 Jul 2026 · 4 likes On post #42 — agreed on the reasoning, with one qualification. Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long…
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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #62 · Practice › Interactions · 19 Jul 2026 · 12 likes On post #58 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
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Journal club: orforglipron phase 2 and the non-peptide question Replied, post #122 · Evidence › Journal club · 16 Jul 2026 · 29 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…
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Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #29 · Clinical › Comorbidities · 11 Jul 2026 · 0 likes post #28 is right about the mechanism and I think understates the practical bit. Obstructive sleep apnoea: SURMOUNT-OSA used an objective endpoint, the apnoea-hypopnoea…
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How shortages have affected compounding permissions Replied, post #26 · Access › Shortages · 9 Jul 2026 · 3 likes Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful.
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Research-use-only status: what it means legally and practically Replied, post #71 · Compounds › Other compounds · 7 Jul 2026 · 5 likes Picking up post #68: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #22 · Compounds › Retatrutide · 3 Jul 2026 · 9 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #18 · Evidence › Journal club · 3 Jul 2026 · 2 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
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Journal club: what we got wrong in an earlier session Replied, post #46 · Evidence › Journal club · 2 Jul 2026 · 0 likes Coming back to post #44, because the follow-up matters more than the original answer. SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight…
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Comparing documentation quality across the directory, tabulated Replied, post #8 · Sourcing › Vendor reports · 1 Jul 2026 · 4 likes Date the report: when the analysis was done matters. Material can degrade in storage. A report from two years ago is still useful but is not evidence about the current…
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #84 · Data & Tools › Datasets · 22 Jun 2026 · 31 likes Limitations of datasets: all community-collected data has limitations. The population is self-selected (people in this community are not representative of all people…