p.krastev

TL2 Moderator · Lyon

Contributes reviews on supplier material. Based in Lyon.

Joined 6 April 2025 · last posted 8d

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How shortages have affected compounding permissions Replied, post #55 · Access › Shortages · 20 Jul 2026 · 6 likes Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your…
Immortal time bias in a claims-database study — one year on Replied, post #33 · Evidence › Study critique · 20 Jul 2026 · 21 likes I read post #31 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Deletion sequences: expected mass shifts by residue — the long version Replied, post #17 · Analytics › Impurities & related substances · 20 Jul 2026 · 10 likes Aggregates: multiples of the monomer mass. May not elute at all under a standard reversed-phase method. A species that does not come off the column does not appear in…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #70 · Evidence › Journal club · 19 Jul 2026 · 30 likes PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy. Non-inferiority for safety was met. The trial was not designed to…
[2026 update] Journal club: what we got wrong in an earlier session Replied, post #6 · Evidence › Journal club · 10 Jul 2026 · 12 likes Picking up post #3: that is the part I would want checked first. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence…
Revisiting: What pooling buys you and what it destroys Replied, post #53 · Evidence › Meta-analyses · 13 Jun 2026 · 6 likes Why forest plots are more informative than pooled numbers: they show the variation across studies, which tells you whether the effect is consistent or heterogeneous. A…
GLP-1 receptor distribution: central and peripheral Replied, post #61 · Pharmacology › Receptor biology · 2 Jun 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Historical amylin analogues and what happened to them Replied, post #14 · Compounds › Cagrilintide & amylin analogues · 1 Jun 2026 · 0 likes What is genuinely unknown about long-term amylin agonism: real-world response rates, whether effect is durable with continued use, whether satiety adaptation occurs…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #34 · Analytics › HPLC & UHPLC · 29 May 2026 · 19 likes I read post #32 twice before replying, because I had assumed the opposite. Reversed-phase separates on hydrophobicity. A peptide is retained on a non-polar stationary…
Tracking intake honestly when appetite is absent Replied, post #40 · Nutrition & Training › Protein & intake · 28 May 2026 · 0 likes This follows post #37 rather than contradicting it. Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #29 · Analytics › Home & field testing · 24 May 2026 · 32 likes post #28 is right about the mechanism and I think understates the practical bit. Enzyme assays: if you have an enzyme that reacts specifically with your compound, an…
An 18-month record including the parts that went badly Replied, post #19 · Outcomes › Progress reports · 18 May 2026 · 0 likes Menstrual cycle: for people who menstruate, weight can shift by several pounds across the cycle due to fluid retention and other factors. Noting cycle phase when…