s.diallo

TL2 Moderator · Faro

Contributes reviews on supplier material. Based in Faro.

Joined 19 October 2024 · last posted 9d

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Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #63 · Analytics › HPLC & UHPLC · 19 Jul 2026 · 1 like Area percent is not mass percent. It is a proportion of absorbance, weighted by each species' extinction coefficient. For closely related impurities the approximation…
Follow-up: Reading an interaction checker output critically Replied, post #53 · Practice › Interactions · 18 Jul 2026 · 0 likes Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you…
Coming back to: Preparing for an appointment: one page, three questions Replied, post #3 · Clinical › Prescriber conversations · 16 Jul 2026 · 33 likes On the opening post — agreed on the reasoning, with one qualification. Discussing off-label dosing: if you want to dose differently than the label specifies (slower…
Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #45 · Clinical › Comorbidities · 12 Jul 2026 · 0 likes Comorbidity control: if a comorbidity (high blood pressure, high lipids) is not adequately controlled, the decision about adding compounds in this class depends on the…
Journal club: what we got wrong in an earlier session Replied, post #67 · Evidence › Journal club · 9 Jul 2026 · 0 likes This follows post #64 rather than contradicting it. Session format: read the paper before posting. The discussion is much better when everyone has. Start with the…
Sulfonylureas: the interaction most worth taking seriously — what changed since Replied, post #5 · Practice › Interactions · 8 Jul 2026 · 0 likes This follows post #2 rather than contradicting it. Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric…
Endotoxin and why it is a separate question from purity — what changed since Replied, post #68 · Analytics › Impurities & related substances · 6 Jul 2026 · 6 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #106 · Evidence › Journal club · 30 Jun 2026 · 3 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…
An 18-month record including the parts that went badly Replied, post #49 · Outcomes › Progress reports · 23 Jun 2026 · 21 likes Worth separating two things that post #45 runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did…
Revisiting: The best-written scientific paper you have read Replied, post #47 · Lounge › Off topic · 23 Jun 2026 · 6 likes This follows post #44 rather than contradicting it. Adjacent and interesting: you might post something about nutrition, bioavailability from a food perspective, or the…
Prescription requirements and telehealth models — a second dataset Replied, post #65 · Sourcing › Regulatory · 14 Jun 2026 · 1 like post #64 is right about the mechanism and I think understates the practical bit. Labelling and intended use: a compound sold as "research-use-only" does not change its…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #61 · Compounds › Semaglutide · 12 Jun 2026 · 11 likes Picking up post #58: that is the part I would want checked first. Is there a ceiling dose beyond which the effect plateaus? The trials did not study that because they…