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New topics page 6

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 6 of 40

Topic	Participants	Replies	Views	Activity
How to disagree with an answer you were given, well Start Here › How to Ask beginner friendly site feedback worked example guidelines Solved Wiki How to disagree with an answer you were given, well — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to include…	+9	13	1.6k	1mo
About the Shortages category Access › Shortages shortage compounding FDA Pinned Wiki Supply interruptions, official shortage notices, and managing an unplanned gap. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…	+3	7	9.9k	1d
Introducing myself and asking whether my planned first topic belongs anywhere — does this still hold? Start Here › Welcome trust levels onboarding guidelines Solved Closed Introducing myself and asking whether my planned first topic belongs anywhere — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. I want to check…		2	36k	2mo
A critique that turned out to be unfair, retracted by its author Evidence › Study critique confounding risk of bias effect size observational data Wiki Posting this under the heading it deserves: A critique that turned out to be unfair, retracted by its author Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+34	38	20k	17h
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+52	57	25k	just now
The arithmetic of an intermediate dose between two label steps Practice › Dosing & titration dose reduction semaglutide missed dose On the subject in the title: The arithmetic of an intermediate dose between two label steps Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…		2	136	2mo
Revisiting: Patterns that reliably precede a problem, documented Sourcing › Red flags underdosing moderation mislabelling documentation quality Posting this under the heading it deserves: Revisiting: Patterns that reliably precede a problem, documented Everything below is what sits behind that. A logistics question, since the answers here are usually…	+16	20	36k	2mo
What would change my mind about repair peptides: a specific answer Compounds › Repair & healing peptides TB-500 needs a source preprint Under review What would change my mind about repair peptides: a specific answer — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA , 2024). Please…	+26	30	1.1k	23h
Purity assay versus content assay: two different numbers Analytics › COA interpretation documentation quality batch & lot numbers reference standards certificate of analysis On the subject in the title: Purity assay versus content assay: two different numbers Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…	+6	10	24k	25d
[2026 update] Reading a chromatogram someone posted without axes Analytics › HPLC & UHPLC peak integration HPLC UV & DAD detection data table Posting this under the heading it deserves: Reading a chromatogram someone posted without axes Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…		2	59	2mo
A pooled estimate that changed when one trial was added Evidence › Meta-analyses meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…	+24	28	3.5k	2d
Composite endpoints and the component doing the work Evidence › Trials randomised trial surrogate endpoints open label discontinuation & dropout Solved Under review Composite endpoints and the component doing the work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I do…	+3	7	33k	13h
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…	+39	49	36k	2d
Mass error in ppm: the arithmetic and the caveat — a second dataset Analytics › Mass spectrometry counter-ion content mass error (ppm) charge states LC-MS Solved On the subject in the title: Mass error in ppm: the arithmetic and the caveat — a second dataset Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+20	24	1.7k	1d
How the vendor documentation pages are maintained, and by whom Sourcing › Vendor reports certificate of analysis Janoshik Analytical batch & lot numbers documentation quality Solved How the vendor documentation pages are maintained, and by whom I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to talk about documentation quality as a…		2	6k	4h
Rewriting my first post: a before-and-after, with commentary — what changed since Start Here › How to Ask site feedback onboarding beginner friendly worked example Posting this under the heading it deserves: Rewriting my first post: a before-and-after, with commentary — what changed since Everything below is what sits behind that. I want to check my reasoning rather…	+15	19	12k	13h
Osteoarthritis and mechanical versus metabolic improvement Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease type 2 diabetes obstructive sleep apnoea Osteoarthritis and mechanical versus metabolic improvement Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+2	6	30k	12h
Revisiting: Bioimpedance and hydration: why the number moves Outcomes › Body composition data table DXA bioimpedance Solved Posting this under the heading it deserves: Revisiting: Bioimpedance and hydration: why the number moves Everything below is what sits behind that. Longitudinal report with the method stated, because a number…		2	2.8k	1mo
Revisiting: The arithmetic of an intermediate dose between two label steps Practice › Dosing & titration titration worked example dose reduction tirzepatide Revisiting: The arithmetic of an intermediate dose between two label steps Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+41	45	808	2mo
Why fasting instructions for oral semaglutide are not optional advice Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Solved Why fasting instructions for oral semaglutide are not optional advice I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016)…	+70	74	1.1k	23d
Stability of BPC-157 in solution: what has been measured Compounds › Repair & healing peptides BPC-157 observational data needs a source TB-500 Stability of BPC-157 in solution: what has been measured — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with FLOW ( N Engl J Med , 2024) and finding the…		2	805	30d
What steady state means for the decision to escalate Practice › Dosing & titration semaglutide titration tirzepatide missed dose Solved What steady state means for the decision to escalate — that is the question, and I have not found it answered plainly anywhere I have looked. Reporting something rather than asking about it, in case the…	+31	35	2k	1d
Books and papers worth reading that are not about this at all — one year on Lounge › Off topic long read beginner friendly Books and papers worth reading that are not about this at all — one year on — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if…	+3	7	424	1mo
Secretagogues and glucose tolerance: the mechanistic concern Compounds › Secretagogues & GH axis CJC-1295 tesamorelin observational data needs a source On the subject in the title: Secretagogues and glucose tolerance: the mechanistic concern Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+64	70	52k	17d
Blinding yourself: practical methods and their limits — the long version Research Methods › N-of-1 designs worked example effect size confounding data table Blinding yourself: practical methods and their limits — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024)…	+7	11	1.8k	22h
Labelling requirements for research chemicals — the long version Sourcing › Regulatory MHRA research use only compounding personal import Posting this under the heading it deserves: Labelling requirements for research chemicals — the long version Everything below is what sits behind that. I would like to talk about documentation quality as a…		2	1.8k	2mo
Why the cheapest option is often not the cheapest Access › Pricing compounding formulary cost per milligram data table Solved Wiki Why the cheapest option is often not the cheapest I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated, because everything in this…	+19	23	1.2k	12h
Shoulders, tangent skims, and defensible integration Analytics › HPLC & UHPLC peak integration UV & DAD detection HPLC gradient method Posting this under the heading it deserves: Shoulders, tangent skims, and defensible integration Everything below is what sits behind that. Posting the method first, because I know what the first three…	+16	20	11k	13h
How this community labels and discusses unrefereed work — the long version Evidence › Preprints needs a source effect size risk of bias Asking directly, because I could not find a straight answer: How this community labels and discusses unrefereed work — the long version I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a…	+18	23	21k	2mo
Mobile reading experience on long topics Meta › Site feedback site feedback moderation guidelines Mobile reading experience on long topics Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in…		2	14k	4h