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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 7 of 40

Topic	Participants	Replies	Views	Activity
Second pass at: Absence of evidence and evidence of absence Research Methods › Statistics worked example confounding number needed to treat On the subject in the title: Second pass at: Absence of evidence and evidence of absence Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before posting;…	+50	55	18k	16h
Injection volume, overload, and peak distortion Analytics › HPLC & UHPLC peak integration system suitability HPLC data table Solved Posting this under the heading it deserves: Injection volume, overload, and peak distortion Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+43	47	36k	2mo
I have no scientific background — can I still follow the analytics categories? Start Here › Welcome onboarding beginner friendly trust levels The question in the title: I have no scientific background — can I still follow the analytics categories? I will give what I have already checked below so nobody repeats it. I want to check my reasoning…	+29	40	1.4k	12d
What to include when your question involves a chromatogram — one year on Start Here › How to Ask worked example guidelines site feedback onboarding Asking directly, because I could not find a straight answer: What to include when your question involves a chromatogram — one year on Question in the title. Context below, and I have tried to include the…	+69	75	862	14d
Follow-up: External review after an internal denial Access › Insurance & coverage prior authorisation formulary insurance Solved Posting this under the heading it deserves: External review after an internal denial Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is what…	+6	10	12k	15h
How shortages have affected compounding permissions — does this still hold? Access › Shortages compounding shortage formulary FDA Solved How shortages have affected compounding permissions — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. A coverage question with the paperwork…	+27	31	21k	17h
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means…	+57	61	708	1d
Bariatric surgery history: altered anatomy, altered expectations Clinical › Special populations pregnancy & planning disordered eating older adults adolescents Solved Posting this under the heading it deserves: Bariatric surgery history: altered anatomy, altered expectations Everything below is what sits behind that. General question, not a request for advice about my own…	+35	39	486	2mo
Second pass at: A pooled estimate that changed when one trial was added Evidence › Meta-analyses effect size risk of bias publication bias meta-analysis Wiki On the subject in the title: Second pass at: A pooled estimate that changed when one trial was added Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+26	30	22k	1mo
Reading a trial's population section before its results Evidence › Trials estimand surrogate endpoints discontinuation & dropout randomised trial Solved On the subject in the title: Reading a trial's population section before its results Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of a claim I do not think it…	+91	109	22k	2mo
Tracking a shortage from primary sources rather than rumour Access › Shortages shortage FDA formulary Tracking a shortage from primary sources rather than rumour — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this category…	+121	126	35k	13h
Naming conventions for research peptides and the confusion they cause Compounds › Other compounds custom synthesis mislabelling research use only needs a source Posting this under the heading it deserves: Naming conventions for research peptides and the confusion they cause Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…	+21	25	4.9k	22d
Angle of injection and whether 90 degrees is always right — the long version Practice › Administration injection site reaction needle gauge & length injection site rotation missed dose Pinned Angle of injection and whether 90 degrees is always right — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it,…	+50	55	15k	2d
Revisiting: Primary endpoint hierarchies and why order matters Evidence › Trials estimand surrogate endpoints discontinuation & dropout intention to treat Posting this under the heading it deserves: Revisiting: Primary endpoint hierarchies and why order matters Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with SURPASS-2 ( N…	+21	25	46k	3mo
About the Oral incretins category Compounds › Oral incretins oral semaglutide orforglipron PIONEER programme Pinned Wiki Oral semaglutide, orforglipron and the absorption problem. PIONEER and OASIS data. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	6.2k	20d
About the Adverse events category Safety › Adverse events pancreatitis vomiting gallbladder Pinned Wiki Serious and unexpected events, how to document them, and where to report them officially. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+2	6	8.7k	2d
What published stability data actually covers, and what it does not Practice › Storage & stability cloudy or discoloured solution freeze-thaw beyond-use date Solved Asking directly, because I could not find a straight answer: What published stability data actually covers, and what it does not Reporting something rather than asking about it, in case the pattern is useful…	+8	12	435	1d
Alcohol: what is documented and what is folklore Practice › Interactions metformin insulin delayed gastric emptying Posting this under the heading it deserves: Alcohol: what is documented and what is folklore Everything below is what sits behind that. A question about technique rather than about dose. I have been doing the…	+120	134	11k	2d
How much fluid is actually needed, and how you would know Nutrition & Training › Hydration & electrolytes heart rate blood pressure fatigue Solved The question in the title: How much fluid is actually needed, and how you would know I will give what I have already checked below so nobody repeats it. Maintenance rather than loss, which is the part of this…	+11	15	53k	2mo
Second pass at: Cagrilintide molecular characteristics and analytical considerations Compounds › Cagrilintide & amylin analogues amylin analogues effect size cagrisema On the subject in the title: Second pass at: Cagrilintide molecular characteristics and analytical considerations Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019).…		4	5k	21d
Cost versus information: making the trade-off explicitly Analytics › Home & field testing LOD & LOQ third-party testing ELISA documentation quality Cost versus information: making the trade-off explicitly Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+2	6	12k	11h
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved On the subject in the title: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of…	+47	53	6.9k	2h
[2026 update] Correlation in a self-tracked dataset: what it can support Research Methods › Statistics number needed to treat effect size worked example heterogeneity Posting this under the heading it deserves: Correlation in a self-tracked dataset: what it can support Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a…		2	31k	6h
[2026 update] Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC UV & DAD detection system suitability peak integration gradient method Solved Why 99.2% and 97.8% on the same lot can both be correct — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this number means before I…	+1	5	719	2d
Why we ask for units every single time, with three examples of what goes wrong — what changed since Start Here › How to Ask onboarding guidelines worked example beginner friendly The question in the title: Why we ask for units every single time, with three examples of what goes wrong — what changed since I will give what I have already checked below so nobody repeats it. Question in…	+14	18	19k	2mo
Reimbursement variation across member states Regional › European Union EMA personal import cost per milligram Reimbursement variation across member states Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what…	+7	11	39k	3mo
Request: show the solution author in the topic list — what changed since Meta › Feature requests site feedback wiki post translation Request: show the solution author in the topic list — what changed since — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation…	+85	91	20k	3mo
Comparing documentation quality across the directory, tabulated Sourcing › Vendor reports third-party testing disputed Janoshik Analytical batch & lot numbers Comparing documentation quality across the directory, tabulated — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately…	+7	11	29k	19h
Coming back to: Reconciling a supplier certificate with an independent result Sourcing › Vendor reports documentation quality certificate of analysis batch & lot numbers Posting this under the heading it deserves: Reconciling a supplier certificate with an independent result Everything below is what sits behind that. Structured report rather than an opinion, following the…	+26	30	45k	16h
Review: a draft on reconstitution arithmetic, with objections — what changed since Documentation › Doc review promoted to docs wiki post review date citation check Posting this under the heading it deserves: Review: a draft on reconstitution arithmetic, with objections — what changed since Everything below is what sits behind that. Nominating something for promotion…	+39	50	26k	22h