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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 9 of 40

Topic	Participants	Replies	Views	Activity
Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+29	36	31k	1d
Tracking intake honestly when appetite is absent Nutrition & Training › Protein & intake constipation fatigue micronutrients lean mass loss Solved On the subject in the title: Tracking intake honestly when appetite is absent Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is not a…	+109	115	4.8k	20h
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Compounds › Semaglutide STEP programme type 2 diabetes randomised trial SELECT trial Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. I have seen SCALE ( N Engl J Med…	+115	122	2.6k	1d
Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition lean mass loss data table bioimpedance DXA Solved On the subject in the title: Two scans six weeks apart on different machines: a cautionary tale Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a…	+18	26	9.4k	2mo
How this community escalates rather than diagnoses — does this still hold? Safety › Adverse events pancreatitis delayed gastric emptying hypoglycaemia vomiting Solved Wiki The question in the title: How this community escalates rather than diagnoses — does this still hold? I will give what I have already checked below so nobody repeats it. Asking about a population rather than…		4	90	29d
Step therapy requirements and how to satisfy them Access › Insurance & coverage prior authorisation insurance formulary Posting this under the heading it deserves: Step therapy requirements and how to satisfy them Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is…	+21	25	49k	2mo
Review: a draft on reconstitution arithmetic, with objections — one year on Documentation › Doc review maintainership citation check promoted to docs review date Review: a draft on reconstitution arithmetic, with objections — one year on Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the…	+46	51	11k	20h
A community side-effect dataset, with its response rate and biases Data & Tools › Datasets confounding site feedback data table observational data Solved A community side-effect dataset, with its response rate and biases — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies…		2	5.1k	19h
Fixed versus detachable needles: the trade-offs — does this still hold? Devices › Syringes & needles syringe units needle gauge & length dead volume subcutaneous injection Solved Fixed versus detachable needles: the trade-offs — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about technique rather than about…	+8	12	39k	15h
What a certificate commits its issuer to — the long version Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards certificate of analysis Asking directly, because I could not find a straight answer: What a certificate commits its issuer to — the long version A documentation question rather than an analytical one. I have a certificate in front…	+20	26	21k	2d
A 40-week log with the measurement method stated — what changed since Outcomes › Progress reports effect size data table DXA long read Solved A 40-week log with the measurement method stated — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a…	+9	13	2.1k	9h
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Analytics › Home & field testing third-party testing LOD & LOQ documentation quality ELISA Solved On the subject in the title: Lateral-flow and colorimetric approaches: the specificity problem Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+77	89	16k	9h
Prescription requirements and telehealth models — a second dataset Sourcing › Regulatory compounding EMA MHRA personal import On the subject in the title: Prescription requirements and telehealth models — a second dataset Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+87	94	1.1k	21d
Revisiting: Spike-and-recover accuracy for a peptide assay Analytics › Method validation LOD & LOQ system suitability stability-indicating method linearity Revisiting: Spike-and-recover accuracy for a peptide assay — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere.…		2	6.8k	21h
Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis observational data tesamorelin GHRP class CJC-1295 Tesamorelin has an approved indication — what that changes about the evidence — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-1 ( N Engl J…	+23	27	3.4k	1d
The best-written scientific paper you have read Lounge › Off topic long read beginner friendly The best-written scientific paper you have read Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if anyone makes a…	+69	74	1.1k	2mo
Tracking semaglutide's approved indications across jurisdictions, dated Compounds › Semaglutide semaglutide effect size SELECT trial Tracking semaglutide's approved indications across jurisdictions, dated Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited…	+15	19	2.8k	1d
Coming back to: Why our vendor pages link the storefront and mark it sponsored Sourcing › Vendor reports third-party testing batch & lot numbers certificate of analysis documentation quality Why our vendor pages link the storefront and mark it sponsored I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following the…		2	22k	8h
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURPASS-2 ( N Engl J Med ,…	+70	76	4.8k	15h
Official shortage notices and what they authorise Access › Shortages compounding formulary shortage Posting this under the heading it deserves: Official shortage notices and what they authorise Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+106	119	18k	1mo
Follow-up: Interpreting a composition change that is within the error bars Outcomes › Body composition DXA lean mass loss bioimpedance data table Solved Interpreting a composition change that is within the error bars Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a number…		2	95	24d
Dizziness on standing: the ordinary explanation first — one year on Nutrition & Training › Hydration & electrolytes fatigue heart rate blood pressure Dizziness on standing: the ordinary explanation first — one year on — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a…	+12	16	1.1k	2d
List price versus negotiated price versus what you pay Access › Pricing formulary data table compounding Under review On the subject in the title: List price versus negotiated price versus what you pay Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires.…	+99	115	11k	3mo
Spike-and-recover accuracy for a peptide assay Analytics › Method validation linearity system suitability stability-indicating method LOD & LOQ Wiki Posting this under the heading it deserves: Spike-and-recover accuracy for a peptide assay Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+121	126	1.5k	4mo
Reflux appearing for the first time at a dose step Practice › Side effects vomiting fatigue hair shedding constipation Reflux appearing for the first time at a dose step — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the same thing for…		4	36k	4mo
Semaglutide formulation: what is in the licensed product besides the peptide Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide formulation: what is in the licensed product besides the peptide — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-1 ( N…	+29	35	4.4k	1h
About the Insurance & coverage category Access › Insurance & coverage insurance prior authorisation appeals Pinned Wiki Prior authorisation, appeals, denial letters, and documentation that helps. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…	+2	6	3.2k	3mo
GLP-1 receptor distribution: central and peripheral — one year on Pharmacology › Receptor biology long read retatrutide amylin analogues semaglutide GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+7	11	43k	3mo
Second pass at: What a 2 ppm match establishes, and what it does not Analytics › Mass spectrometry MALDI-TOF mass error (ppm) counter-ion content high-resolution MS Second pass at: What a 2 ppm match establishes, and what it does not — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…	+44	49	8.1k	1d
Follow-up: Sleep quality changes during weight loss Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I would…	+74	80	4.4k	14h