Tags · Evidence

observational data

Cohort, registry and claims data, with the confounding that comes with it.

67 topics 21 solved Group: Evidence

Compounds 33 Evidence 20 Data & Tools 14

67 topics · page 2 of 3

Topic	Participants	Replies	Views	Activity
Reverse causation in a cohort study of weight and outcome Evidence › Study critique disputed observational data effect size On the subject in the title: Reverse causation in a cohort study of weight and outcome Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with FLOW ( N Engl J Med , 2024) and…	+10	14	11k	7mo
Selection into a registry and what it does to the estimate Evidence › Study critique risk of bias disputed observational data Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…		2	55k	7mo
Critiquing an observational claim about a class effect — one year on Evidence › Study critique observational data disputed risk of bias Pinned Critiquing an observational claim about a class effect — one year on — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim…	+5	9	3.2k	8mo
Revisiting: Sample size in a voluntary survey: the selection problem Data & Tools › Datasets data table confounding site feedback observational data Solved Revisiting: Sample size in a voluntary survey: the selection problem — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies…		2	56k	9mo
Aggregated purity results across four services, with caveats Data & Tools › Datasets observational data site feedback data table Posting this under the heading it deserves: Aggregated purity results across four services, with caveats Everything below is what sits behind that. Working through the identity arithmetic and I would like it…		3	24k	9mo
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback confounding data table On the subject in the title: A community side-effect dataset, with its response rate and biases Working notes rather than a conclusion. Posting the method first, because I know what the first three replies…	+27	31	46k	9mo
Reading a rodent study on a secretagogue without over-extrapolating Compounds › Secretagogues & GH axis observational data GHRP class CJC-1295 needs a source Closed Posting this under the heading it deserves: Reading a rodent study on a secretagogue without over-extrapolating Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of…	+50	54	32k	10mo
BPC-157: what the rodent literature actually shows, and what it does not Compounds › Repair & healing peptides observational data preprint BPC-157 needs a source BPC-157: what the rodent literature actually shows, and what it does not — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a…	+44	48	3k	10mo
Analytical identity of BPC-157: a 15-mer with a simple mass Compounds › Repair & healing peptides BPC-157 observational data needs a source preprint Analytical identity of BPC-157: a 15-mer with a simple mass Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with STEP 2 (…	+3	7	5.2k	10mo
Reverse causation in a cohort study of weight and outcome — a second dataset Evidence › Study critique risk of bias observational data confounding Reverse causation in a cohort study of weight and outcome — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+112	131	1.5k	10mo
Aggregated purity results across four services, with caveats — a second dataset Data & Tools › Datasets data table confounding site feedback observational data Closed Aggregated purity results across four services, with caveats — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like…	+127	151	42k	10mo
Second pass at: Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data ipamorelin tesamorelin needs a source Second pass at: Why this subcategory is stricter about sourcing than most — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-4 ( JAMA ,…	+120	129	61k	11mo
Confounding by indication, explained with a concrete example Evidence › Study critique confounding observational data disputed On the subject in the title: Confounding by indication, explained with a concrete example Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-2 ( N Engl J Med ,…	+21	25	21k	11mo
Immortal time bias in a claims-database study Evidence › Study critique risk of bias observational data disputed confounding Closed Immortal time bias in a claims-database study — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+29	34	28k	11mo
TB-500 and thymosin beta-4: the fragment versus the protein Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint TB-500 and thymosin beta-4: the fragment versus the protein Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…	+107	118	22k	11mo
BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Compounds › Repair & healing peptides TB-500 preprint observational data needs a source Solved On the subject in the title: BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019)…	+77	84	54k	11mo
IGF-1 as a surrogate endpoint and its limitations — the long version Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved Closed On the subject in the title: IGF-1 as a surrogate endpoint and its limitations — the long version Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of a claim I do…	+14	18	53k	12mo
About the Datasets category Data & Tools › Datasets data table observational data confounding Pinned Wiki Community-collected datasets, their collection methods, and their limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…	+6	11	42k	12mo
About the Repair & healing peptides category Compounds › Repair & healing peptides BPC-157 TB-500 observational data Pinned Wiki BPC-157, TB-500 and similar. Mostly preclinical evidence; this subcategory is strict about not overstating it. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…		4	19k	13mo
Whether an aggregate is worth publishing at all: a disputed topic Data & Tools › Datasets confounding site feedback observational data On the subject in the title: Whether an aggregate is worth publishing at all: a disputed topic Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+20	24	18k	13mo
Why plausible mechanism is not evidence of effect Compounds › Repair & healing peptides TB-500 preprint observational data Solved Closed Asking directly, because I could not find a straight answer: Why plausible mechanism is not evidence of effect Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the discussion is much…	+14	18	57k	13mo
A claim built entirely on a subgroup analysis Evidence › Study critique risk of bias observational data confounding disputed Solved A claim built entirely on a subgroup analysis Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do…	+71	80	1.1k	14mo
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with LEADER ( N Engl J Med ,…	+117	128	7.2k	14mo
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis CJC-1295 needs a source tesamorelin observational data Posting this under the heading it deserves: Tesamorelin has an approved indication — what that changes about the evidence Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with…	+63	68	18k	14mo
Critiquing an observational claim about a class effect Evidence › Study critique disputed risk of bias effect size observational data Posting this under the heading it deserves: Critiquing an observational claim about a class effect Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…		2	6.9k	14mo
Ipamorelin selectivity claims and where they came from — a second dataset Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin ipamorelin Posting this under the heading it deserves: Ipamorelin selectivity claims and where they came from — a second dataset Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021)…		2	27k	14mo
Coming back to: A critique that turned out to be unfair, retracted by its author Evidence › Study critique disputed observational data effect size confounding Closed A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not…		2	1.3k	14mo
Criticising the method without criticising the authors Evidence › Study critique disputed observational data confounding effect size Criticising the method without criticising the authors Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim…	+55	61	60k	15mo
Revisiting: Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides observational data needs a source TB-500 BPC-157 Solved On the subject in the title: Revisiting: Oral versus injected administration claims for BPC-157 Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+23	27	7.7k	15mo
Sample size in a voluntary survey: the selection problem Data & Tools › Datasets observational data data table site feedback Solved Posting this under the heading it deserves: Sample size in a voluntary survey: the selection problem Everything below is what sits behind that. Posting the method first, because I know what the first three…	+1	5	12k	15mo