Ranked by engagement

Top topics — this week page 4

Ranked by replies, likes and views over this week, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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314 topics · page 4 of 11

Topic	Participants	Replies	Views	Activity
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…	+39	49	36k	2d
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURPASS-2 ( N Engl J Med ,…	+70	76	4.8k	15h
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+63	74	11k	1d
A 10 mg vial reconstituted three different ways, compared Practice › Reconstitution bacteriostatic water worked example concentration maths Posting this under the heading it deserves: A 10 mg vial reconstituted three different ways, compared Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+30	34	55k	17h
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+55	59	26k	2d
Follow-up: How compounding permissions changed when supply normalised Sourcing › Regulatory MHRA personal import research use only How compounding permissions changed when supply normalised I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following the…	+72	77	1.5k	1d
Coming back to: A structured critique template this community uses Evidence › Study critique confounding risk of bias disputed observational data Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with SURMOUNT-1 ( N Engl J Med , 2022)…	+63	69	17k	18h
Pancreatitis history and the risk calculus Safety › Contraindications delayed gastric emptying thyroid C-cell question pancreatitis pregnancy & planning Solved Posting this under the heading it deserves: Pancreatitis history and the risk calculus Everything below is what sits behind that. Asking about a population rather than about a person. The published trials in…	+28	32	52k	17h
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC HPLC system suitability gradient method Detection wavelength and why 214 nm and 280 nm disagree — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will…	+69	76	920	6h
The headache that turns out to be dehydration — the long version Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate Under review On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a…	+68	73	1.3k	12h
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+52	57	25k	just now
Angle of injection and whether 90 degrees is always right — the long version Practice › Administration injection site reaction needle gauge & length injection site rotation missed dose Pinned Angle of injection and whether 90 degrees is always right — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it,…	+50	55	15k	2d
Blinding yourself: practical methods and their limits Research Methods › N-of-1 designs confounding data table effect size On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with STEP 4 ( JAMA , 2021) and finding the…	+40	44	33k	5d
How shortages have affected compounding permissions Access › Shortages shortage compounding FDA formulary How shortages have affected compounding permissions I have a specific reason for asking rather than idle curiosity, and the context is below. A coverage question with the paperwork detail included, since that…	+61	71	3.6k	2d
Aggregate verification data across the directory, with caveats Sourcing › Independent verification Medutest blind sampling PeptideMeter Under review On the subject in the title: Aggregate verification data across the directory, with caveats Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+64	74	4.6k	14h
Follow-up: Reading an interaction checker output critically Practice › Interactions insulin hypoglycaemia delayed gastric emptying needs a source Solved Reading an interaction checker output critically — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I am asking rather…	+62	66	13k	2d
Reused chromatograms across lots: how to spot it Analytics › COA interpretation batch & lot numbers amino acid analysis documentation quality certificate of analysis On the subject in the title: Reused chromatograms across lots: how to spot it Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of…	+53	60	9.5k	4h
Why the Start Here categories exist, and what they are not for Start Here › Welcome guidelines trust levels onboarding beginner friendly Solved Why the Start Here categories exist, and what they are not for — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried…	+40	44	32k	1d
Chain of custody for a sample you posted yourself — one year on Sourcing › Independent verification VendorInvestigate Janoshik Analytical blind sampling third-party testing Posting this under the heading it deserves: Chain of custody for a sample you posted yourself — one year on Everything below is what sits behind that. Structured report rather than an opinion, following the…	+28	32	50k	15h
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Compounds › Retatrutide retatrutide preprint randomised trial effect size Solved The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med…	+43	47	19k	2d
Packaging that arrived damaged: documenting it properly Sourcing › Logistics shipping customs temperature excursion cold chain Pinned Packaging that arrived damaged: documenting it properly Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than…	+43	49	26k	1d
Review: a draft on reconstitution arithmetic, with objections — one year on Documentation › Doc review maintainership citation check promoted to docs review date Review: a draft on reconstitution arithmetic, with objections — one year on Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the…	+46	51	11k	20h
[2026 update] Currency conversion and the cost you did not see Sourcing › Payments research use only payments documentation quality Solved Posting this under the heading it deserves: Currency conversion and the cost you did not see Everything below is what sits behind that. A logistics question, since the answers here are usually better than…	+21	26	52k	2d
Shakes versus food: a pragmatic assessment Nutrition & Training › Protein & intake lean mass loss micronutrients constipation Shakes versus food: a pragmatic assessment Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost nobody writes…	+22	26	53k	20h
NHS criteria and how they are applied in practice Regional › UK & Ireland NHS cost per milligram personal import MHRA NHS criteria and how they are applied in practice — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines…	+37	42	31k	2d
What changed in 2026, by region — does this still hold? Access › International personal import MHRA EMA telehealth Solved What changed in 2026, by region — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated, because everything in…	+20	25	50k	1d
A structured critique template this community uses — a second dataset Evidence › Study critique observational data effect size confounding Solved On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+47	51	16k	15h
Ultrasound and skinfolds: operator dependence in practice Outcomes › Body composition DXA data table lean mass loss Ultrasound and skinfolds: operator dependence in practice — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody…	+72	76	2.7k	2d
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint Solved Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet ,…	+50	55	7.8k	2d
Review: a draft on reconstitution arithmetic, with objections — what changed since Documentation › Doc review promoted to docs wiki post review date citation check Posting this under the heading it deserves: Review: a draft on reconstitution arithmetic, with objections — what changed since Everything below is what sits behind that. Nominating something for promotion…	+39	50	26k	22h