Ranked by engagement

Top topics — this week page 5

Ranked by replies, likes and views over this week, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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314 topics · page 5 of 11

Topic	Participants	Replies	Views	Activity
Second pass at: Absence of evidence and evidence of absence Research Methods › Statistics worked example confounding number needed to treat On the subject in the title: Second pass at: Absence of evidence and evidence of absence Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before posting;…	+50	55	18k	16h
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means…	+57	61	708	1d
What a good consultation looks like from the other side Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes beginner friendly What a good consultation looks like from the other side — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about a population rather than about a person. The…	+57	62	4.9k	22h
Coming back to: Reconciling a supplier certificate with an independent result Sourcing › Vendor reports documentation quality certificate of analysis batch & lot numbers Posting this under the heading it deserves: Reconciling a supplier certificate with an independent result Everything below is what sits behind that. Structured report rather than an opinion, following the…	+26	30	45k	16h
Vomiting: when it is expected and when it is a reason to stop — one year on Practice › Side effects nausea vomiting hair shedding Vomiting: when it is expected and when it is a reason to stop — one year on Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it,…	+19	23	49k	18h
Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+29	36	31k	1d
Coming back to: Preparing for an appointment: one page, three questions Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes prior authorisation Preparing for an appointment: one page, three questions — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+51	56	1.4k	2d
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation precision & repeatability LOD & LOQ linearity Specificity, linearity, accuracy, precision, range, robustness — with real criteria Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this…	+44	48	12k	1d
Coming back to: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration dose reduction semaglutide titration tirzepatide Solved Posting this under the heading it deserves: Where the four-week escalation interval comes from, and what it is not Everything below is what sits behind that. I have read the maintained page on this and I…	+44	48	11k	1d
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+38	43	29k	13h
Which categories are strict and which are relaxed, honestly Start Here › Welcome onboarding beginner friendly guidelines trust levels Solved Which categories are strict and which are relaxed, honestly I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather than get a conclusion.…	+47	53	1.8k	2d
What I would want from a home test that does not exist yet Analytics › Home & field testing ELISA documentation quality LOD & LOQ Solved Pinned The question in the title: What I would want from a home test that does not exist yet I will give what I have already checked below so nobody repeats it. A documentation question rather than an analytical…	+46	50	8k	6h
Second pass at: What a 2 ppm match establishes, and what it does not Analytics › Mass spectrometry MALDI-TOF mass error (ppm) counter-ion content high-resolution MS Second pass at: What a 2 ppm match establishes, and what it does not — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…	+44	49	8.1k	1d
Second pass at: When your prescriber and the evidence disagree Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth prior authorisation Pinned Second pass at: When your prescriber and the evidence disagree — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+51	55	9.2k	2d
Coming back to: Payment method and the leverage it gives you, ranked Sourcing › Payments payments documentation quality research use only Payment method and the leverage it gives you, ranked — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the maintainers asked…	+21	26	43k	2d
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved On the subject in the title: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of…	+47	53	6.9k	2h
eGFR fluctuation and the creatinine denominator problem — the long version Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase Under review eGFR fluctuation and the creatinine denominator problem — the long version — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…	+43	47	17k	just now
Request: tag synonyms surfaced in search Meta › Feature requests wiki post translation site feedback Solved On the subject in the title: Request: tag synonyms surfaced in search Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level page…	+23	27	38k	3h
Restarting after a long gap: what the labelling implies Practice › Dosing & titration dose reduction semaglutide titration missed dose Posting this under the heading it deserves: Restarting after a long gap: what the labelling implies Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+41	46	11k	15h
A critique that turned out to be unfair, retracted by its author Evidence › Study critique confounding risk of bias effect size observational data Wiki Posting this under the heading it deserves: A critique that turned out to be unfair, retracted by its author Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+34	38	20k	17h
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Compounds › Retatrutide randomised trial effect size TRIUMPH programme retatrutide Solved Asking directly, because I could not find a straight answer: What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Session topic: STEP 2 ( Lancet , 2021). Please read…	+43	47	5.5k	just now
Revisiting: Can a home kit substitute for a laboratory report? A careful no Analytics › Home & field testing ELISA LOD & LOQ documentation quality third-party testing Revisiting: Can a home kit substitute for a laboratory report? A careful no — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+50	56	9.8k	1d
Washout with a one-week half-life: the arithmetic — does this still hold? Research Methods › N-of-1 designs confounding data table worked example Solved Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+41	45	12k	1d
A fridge failure and how I assessed the contents afterwards Devices › Cold chain cold chain storage temperature excursion A fridge failure and how I assessed the contents afterwards Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a gap,…	+14	18	46k	17h
Batch numbers that do not match the vial label Sourcing › Red flags mislabelling disputed moderation underdosing Solved Batch numbers that do not match the vial label — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately from product…	+43	48	8.9k	2d
Documenting a supplier's response to a discrepancy Sourcing › Vendor reports third-party testing documentation quality batch & lot numbers Solved On the subject in the title: Documenting a supplier's response to a discrepancy Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers asked…	+44	49	589	8h
Follow-up: Signs of dehydration worth acting on Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia Posting this under the heading it deserves: Signs of dehydration worth acting on Everything below is what sits behind that. General question, not a request for advice about my own care — I know the difference…	+35	39	9.8k	1d
Immortal time bias in a claims-database study — one year on Evidence › Study critique effect size risk of bias confounding Solved Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with SURMOUNT-1 (…	+41	46	3.7k	22h
Publication patterns in the BPC-157 literature, examined Compounds › Repair & healing peptides preprint BPC-157 TB-500 needs a source Solved Posting this under the heading it deserves: Publication patterns in the BPC-157 literature, examined Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of…	+40	45	3.4k	21h
About the Impurities & related substances category Analytics › Impurities & related substances forced degradation counter-ion content water content Pinned Wiki Deletion sequences, oxidation, deamidation, aggregates, residual solvents, and counter-ion content. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+6	10	50k	15h