an.kirchner
TL2 Moderator · Rosario
Contributes reviews on supplier material. Based in Rosario.
Joined 23 September 2024 · last posted 2d
98 posts, newest first. Showing up to 150.
-
Prescription portability between countries Replied, post #113 · Access › International · 26 Jul 2026 · 15 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
-
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #110 · Sourcing › Independent verification · 21 Jul 2026 · 0 likes Interpreting a result: a purity figure is one measurement on one vial on one day. Agreement across two services is much stronger. A single high number does not…
-
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #73 · Practice › Administration · 19 Jul 2026 · 0 likes Coming back to post #71, because the follow-up matters more than the original answer. Injecting into an area that has become firm: lipohypertrophy — thickened fatty…
-
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #73 · Practice › Dosing & titration · 17 Jul 2026 · 7 likes The four-week escalation interval is a convention from the pivotal trials, not a pharmacological constant. The pharmacological argument is that with a week-long…
-
[2026 update] Documenting an adverse event properly Replied, post #11 · Safety › Adverse events · 16 Jul 2026 · 1 like post #10 answers the question as asked. The question underneath it is different. Pancreatitis is a genuine serious adverse event to know: severe epigastric pain, back…
-
I joined for one answer and stayed for a year — what changed my mind Replied, post #82 · Start Here › Welcome · 14 Jul 2026 · 0 likes Worth separating two things that post #78 runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did…
-
Why the cheapest option is often not the cheapest Replied, post #16 · Access › Pricing · 5 Jul 2026 · 0 likes List prices versus negotiated prices: the price a pharmaceutical company publishes and the price an insurance company or pharmacy actually pays differ substantially.…
-
Revisiting: Protein density versus volume when you cannot eat much Replied, post #29 · Nutrition & Training › Protein & intake · 3 Jul 2026 · 27 likes Fibre: adequate fibre intake supports fullness and gut motility, both of which matter during the gastrointestinal effects of these compounds. High fibre on top of…
-
A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #77 · Practice › Interactions · 3 Jul 2026 · 1 like Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you…
-
Lipid changes during rapid weight loss: the expected trajectory Replied, post #9 · Clinical › Bloodwork · 2 Jul 2026 · 1 like Biological variation: the person-to-person variation in a biomarker for a healthy person is larger than most people realize. Comparing your result to the reference…
-
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #15 · Analytics › Home & field testing · 20 Jun 2026 · 10 likes post #14 is right about the mechanism and I think understates the practical bit. False positives and false negatives: no test has 100% sensitivity and 100% specificity.…
-
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #63 · Wellbeing › Sleep · 19 Jun 2026 · 0 likes Stimulants and sleep: if supplementing with caffeine or other stimulants for energy during weight loss, timing and dose matter for sleep. Evening stimulant use…
-
Racemisation and why it is invisible to a mass measurement Replied, post #70 · Analytics › Impurities & related substances · 12 Jun 2026 · 2 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
-
Second pass at: Cost versus information: making the trade-off explicitly Replied, post #5 · Analytics › Home & field testing · 11 Jun 2026 · 20 likes Precision of home tests: most consumer-accessible devices are not precise to the level people want ("is this 99% pure or 97% pure"). They give a yes/no or a rough…
-
Why the timeline is on the right and not the left — what changed since Replied, post #51 · Meta › Site feedback · 8 Jun 2026 · 0 likes Moderation decisions: if you disagree with a moderation decision, raising it here gives it visibility. Staff will reconsider if you make a substantive case.
-
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #112 · Sourcing › Red flags · 7 Jun 2026 · 26 likes Rapid supplier turnover: a supplier that changes corporate structure, domain name, or contact repeatedly in short time windows raises suspicion about stability and…
-
The most useful thing you learned here that was not the answer you came for Replied, post #46 · Lounge › Off topic · 29 May 2026 · 0 likes Picking up post #43: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
-
Measurement error in home scales, with a worked standard deviation — the long version Replied, post #101 · Research Methods › Statistics · 10 May 2026 · 8 likes Coming back to post #99, because the follow-up matters more than the original answer. Relative risk and odds ratios: both compare the rate in one group to the rate in…
-
Amylin receptor signalling and satiety — what changed since Replied, post #76 · Pharmacology › Receptor biology · 9 May 2026 · 2 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
-
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #72 · Outcomes › Body composition · 8 May 2026 · 0 likes Picking up post #69: that is the part I would want checked first. Precision versus accuracy: the precision you need depends on what question you are answering. "Am I…
-
[2026 update] Waist circumference technique and its repeatability Replied, post #8 · Outcomes › Progress reports · 7 May 2026 · 5 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
-
Blinding yourself: practical methods and their limits Replied, post #23 · Research Methods › N-of-1 designs · 5 May 2026 · 28 likes Designing a personal experiment that could actually change your mind: that is the standard for an n-of-1 design. An experiment designed so that any result confirms what…
-
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #113 · Analytics › Mass spectrometry · 25 Apr 2026 · 0 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass.
-
Converting between mg/mL and units per dose, both directions — the long version Replied, post #99 · Practice › Reconstitution · 24 Apr 2026 · 0 likes Choosing a concentration on purpose rather than by accident: starting with "I want to draw 0.5 mL per dose" and working backward to the required concentration is more…
-
What a certificate commits its issuer to — one year on Replied, post #55 · Analytics › COA interpretation · 24 Apr 2026 · 9 likes Coming back to post #53, because the follow-up matters more than the original answer. When a document puts the specification in the result column, it has told you the…
-
Journal club: is percentage weight change the right endpoint? Replied, post #50 · Evidence › Journal club · 8 Apr 2026 · 4 likes TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not finished. When it does, this discussion will return to it.
-
[2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #89 · Practice › Storage & stability · 29 Mar 2026 · 1 like Worth separating two things that post #85 runs together. Temperature excursions: if a vial sat at room temperature for a time, the question is whether the excursion was…
-
Follow-up: Search filters: what is missing Replied, post #50 · Meta › Site feedback · 10 Mar 2026 · 9 likes I read post #48 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
-
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #58 · Pharmacology › Pharmacokinetics · 2 Mar 2026 · 30 likes Hepatic metabolism: the degree to which each compound is hepatically metabolised versus renally cleared is known but varies. Severe liver disease changes clearance.
-
Trifluoroacetate content and its consequences Replied, post #14 · Analytics › Impurities & related substances · 23 Jan 2026 · 16 likes On post #10 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
-
Publication bias detection and its low power — does this still hold? Replied, post #7 · Evidence › Meta-analyses · 16 Jan 2026 · 29 likes Why forest plots are more informative than pooled numbers: they show the variation across studies, which tells you whether the effect is consistent or heterogeneous. A…
-
Coming back to: Training through a dose escalation week Replied, post #9 · Nutrition & Training › Resistance training · 15 Jan 2026 · 1 like Post-weight-loss training: once weight loss is complete and energy deficit ends, training can shift to building again. The transition from preservation mode to building…
-
A partial dose because the pen emptied mid-injection Replied, post #56 · Practice › Administration · 9 Jan 2026 · 0 likes A genuinely late dose: the labelling generally says that if the next dose is more than a couple of days away, take it as soon as you notice. If the next dose is close,…
-
Aggregates and why a purity assay may miss them entirely Replied, post #34 · Analytics › Impurities & related substances · 28 Dec 2025 · 2 likes On post #30 — agreed on the reasoning, with one qualification. Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue.…
-
Promotion criteria, and the one that stops most nominations — the long version Replied, post #118 · Documentation › Doc review · 23 Dec 2025 · 16 likes I read post #116 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
-
Publishing an inconvenient result: a case study — the long version Replied, post #70 · Sourcing › Independent verification · 14 Dec 2025 · 2 likes Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies…
-
The headache that turns out to be dehydration Replied, post #90 · Nutrition & Training › Hydration & electrolytes · 11 Dec 2025 · 0 likes This follows post #87 rather than contradicting it. Lab testing: if symptoms are severe or persistent, checking electrolytes and minerals (sodium, potassium, magnesium,…
-
Lipase elevation without symptoms: the interpretation problem Replied, post #16 · Clinical › Bloodwork · 8 Dec 2025 · 23 likes Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is…
-
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #31 · Access › Pricing · 6 Dec 2025 · 14 likes This follows post #28 rather than contradicting it. Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies…
-
Comparing two chromatograms from different laboratories, properly Replied, post #34 · Analytics › HPLC & UHPLC · 25 Nov 2025 · 2 likes Peak purity: a diode-array detector records a spectrum at every time point. If a peak contains two co-eluting species with different spectra, the spectrum changes…
-
Revisiting: Absolute versus relative contraindications Replied, post #6 · Safety › Contraindications · 24 Nov 2025 · 0 likes Diabetic retinopathy complications: a signal for this was noted in SUSTAIN 6. Current evidence is mixed. The risk is not zero and some caution is appropriate in people…
-
Journal club: PIONEER 6 as a safety trial Replied, post #9 · Evidence › Journal club · 23 Nov 2025 · 0 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
-
Lurking for two months before posting: was that the right call? Replied, post #38 · Start Here › Welcome · 19 Nov 2025 · 2 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
-
Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #11 · Data & Tools › Calculators · 18 Nov 2025 · 8 likes Precision and significant figures: the calculators do not round to match your input precision. If you input values to one decimal place, the output might have more. Use…
-
[2026 update] What steady state means for the decision to escalate Replied, post #110 · Practice › Dosing & titration · 16 Nov 2025 · 0 likes Coming back to post #108, because the follow-up matters more than the original answer. The arithmetic of an intermediate dose: if the label says 1.0 mg and 2.0 mg, a…
-
Pen dose counters: what a click does and does not guarantee Replied, post #15 · Devices › Pens & autoinjectors · 13 Nov 2025 · 0 likes On post #11 — agreed on the reasoning, with one qualification. Visibility of the dose: some pens allow you to see the insulin remaining; others do not. Keeping track…
-
Moderation log format change Replied, post #7 · Meta › Announcements · 7 Nov 2025 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
-
MHRA statements, read directly Replied, post #21 · Regional › UK & Ireland · 26 Oct 2025 · 20 likes Importing for personal use: importing a prescription-only medicine without a prescription is not lawful. Material sold as research-use-only is not a licensed medicine…
-
Titles that describe the question, not the situation Replied, post #131 · Start Here › How to Ask · 25 Oct 2025 · 0 likes Arithmetic questions: write out the steps. "I have a 10 mg vial, I added 2 mL, I want a 0.25 mg dose, and I get this number for the syringe mark" is answerable. "How…
-
New subcategory: rationale and scope Replied, post #47 · Meta › Announcements · 17 Oct 2025 · 3 likes RSS: if you prefer to receive announcements by feed rather than visiting the site, RSS is available for this subcategory.
-
[2026 update] Scheduled maintenance and what will be unavailable Replied, post #16 · Meta › Announcements · 14 Oct 2025 · 11 likes Picking up post #13: that is the part I would want checked first. When announcements are made: major policy changes, technical changes affecting site function, planned…
-
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #43 · Compounds › Oral incretins · 28 Sep 2025 · 0 likes Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing apples to a different fruit. The oral bioavailability is low…
-
Why the timeline is on the right and not the left Replied, post #62 · Meta › Site feedback · 1 Sep 2025 · 10 likes Display issues: broken layouts, images not loading, text overlapping — report with the browser and device you were using. Display bugs are platform-specific.
-
Vagal afferents and the gut-brain pathway — one year on Started this topic · Pharmacology › Receptor biology · 28 Aug 2025 · 17 likes Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. A documentation question…
-
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Replied, post #32 · Practice › Dosing & titration · 27 Aug 2025 · 12 likes Picking up post #29: that is the part I would want checked first. Micro-titration: the concept of increments smaller than the labelled steps. It has no evidence base…
-
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #95 · Compounds › Secretagogues & GH axis · 24 Aug 2025 · 26 likes CJC-1295 with and without DAC: the version with a drug affinity complex binds albumin covalently and persists for days. The version without it does not persist.…
-
Enforcement priorities versus written rules — does this still hold? Replied, post #16 · Sourcing › Regulatory · 18 Aug 2025 · 0 likes Why this category is maintained as documentation, not as recommendations: the goal is factual accuracy and sourcing, not endorsement of any specific regulatory position.
-
A request that was declined, and the reasoning — a second dataset Replied, post #29 · Documentation › Wiki requests · 8 Aug 2025 · 0 likes Worth separating two things that post #25 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
-
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #153 · Compounds › Tirzepatide · 2 Aug 2025 · 7 likes Mass and charge states: tirzepatide is about 4813.5 Da and on an electrospray instrument you would expect to see charge states mostly in the 2+ to 4+ range, the same as…
-
Coming back to: Official shortage notices and what they authorise Replied, post #63 · Access › Shortages · 20 Jul 2025 · 0 likes Coming back to post #61, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the first…
-
Second pass at: A history of disordered eating: proceeding carefully Replied, post #78 · Wellbeing › Mental health · 27 Jun 2025 · 9 likes Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.
-
Area percent versus weight percent: the confusion that causes most arguments — what… Replied, post #29 · Analytics › HPLC & UHPLC · 26 Jun 2025 · 6 likes Area percent is not mass percent. It is a proportion of absorbance, weighted by each species' extinction coefficient. For closely related impurities the approximation…
-
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #10 · Analytics › HPLC & UHPLC · 22 Jun 2025 · 0 likes I read post #8 twice before replying, because I had assumed the opposite. Method validation is the demonstration that a method can separate the compound from its…
-
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #54 · Clinical › Comorbidities · 18 Jun 2025 · 15 likes post #53 is right about the mechanism and I think understates the practical bit. Comorbidity control: if a comorbidity (high blood pressure, high lipids) is not…
-
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #12 · Compounds › Semaglutide · 9 Jun 2025 · 0 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
-
A report I filed that turned out to be wrong, and the correction Replied, post #81 · Sourcing › Vendor reports · 1 Jun 2025 · 15 likes Coming back to post #79, because the follow-up matters more than the original answer. Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if…
-
Checking someone else's arithmetic: a worked example thread Replied, post #51 · Practice › Reconstitution · 26 May 2025 · 4 likes Osmolarity and reconstitution: the osmolarity of the reconstituted solution affects comfort on injection. Isotonic solutions (close to blood osmolarity) are less…
-
UK access routes, dated and sourced — a second dataset Replied, post #82 · Regional › UK & Ireland · 24 May 2025 · 17 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
-
Why plausible mechanism is not evidence of effect Replied, post #5 · Compounds › Repair & healing peptides · 13 Apr 2025 · 8 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
-
Review: a draft on reconstitution arithmetic, with objections Replied, post #99 · Documentation › Doc review · 10 Apr 2025 · 0 likes Promoted topic withdrawal: if a promoted topic becomes outdated or inaccurate and the maintainer does not update, requesting withdrawal is appropriate.
-
Coming back to: What published stability data actually covers, and what it does not Replied, post #15 · Practice › Storage & stability · 3 Apr 2025 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
-
Reading order for a first week here, and what to skip until later Replied, post #60 · Start Here › Welcome · 31 Mar 2025 · 4 likes The FAQ link in the sidebar is maintained and worth ten hours of forum browsing. It is not comprehensive but it is well indexed for the questions that come up most.
-
Request declined, with reasoning Replied, post #2 · Meta › Feature requests · 25 Mar 2025 · 14 likes Effort estimation: some features are trivial to implement; others are substantial work. Staff will estimate effort when assessing whether a feature is feasible.
-
Coverage for the indication versus for the drug Replied, post #2 · Access › Insurance & coverage · 14 Mar 2025 · 4 likes Out-of-pocket costs: if insurance is not covering it, asking about patient assistance programmes run by manufacturers can reduce costs. Eligibility requirements exist…
-
Triple agonism: additive, synergistic, or neither? Replied, post #25 · Compounds › Retatrutide · 9 Mar 2025 · 1 like Coming back to post #23, because the follow-up matters more than the original answer. Dose escalation in the published trials: the protocols started at lower doses and…
-
Pharmaceutical compounding rules, summarised from primary sources Replied, post #95 · Sourcing › Regulatory · 3 Mar 2025 · 0 likes Approval versus licensing: a compound can be approved for a specific indication in one country and not approved at all in another. Tracking jurisdictional approval is…
-
Second pass at: Pharmacy supply in the UK and the questions you will be asked Replied, post #20 · Regional › UK & Ireland · 3 Mar 2025 · 23 likes On post #16 — agreed on the reasoning, with one qualification. Supply and shortage resilience: both UK and Ireland sourced primarily from European suppliers until…
-
Pharmaceutical compounding rules, summarised from primary sources Replied, post #74 · Sourcing › Regulatory · 2 Mar 2025 · 12 likes Off-label use and medical practice: clinicians can prescribe approved medications off-label under some circumstances. That is different from research-use-only…
-
A ten-fold dose error caught before injection Replied, post #5 · Devices › Syringes & needles · 2 Mar 2025 · 15 likes Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if…
-
Reading an MS report that only gives you a single number — the long version Replied, post #3 · Analytics › Mass spectrometry · 28 Jan 2025 · 0 likes What mass accuracy establishes: the measured mass is consistent with a specific composition. What it does not establish: purity, sequence order, stereochemistry, or the…
-
Distinguishing a deletion sequence by mass alone Replied, post #15 · Analytics › Mass spectrometry · 24 Jan 2025 · 0 likes post #14 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
-
What we do not know about retatrutide, listed explicitly Replied, post #58 · Compounds › Retatrutide · 16 Jan 2025 · 14 likes On post #54 — agreed on the reasoning, with one qualification. Mass and identity: a report on retatrutide should state the mass detected by LC-MS, not assume a…
-
Follow-up: Individual participant data versus aggregate data Replied, post #79 · Evidence › Meta-analyses · 11 Jan 2025 · 12 likes Sensitivity analysis: the authors re-run the meta-analysis excluding studies one at a time, or by quality, to see whether the pooled estimate changes. Robust results…
-
[2026 update] New subcategory: rationale and scope Replied, post #112 · Meta › Announcements · 1 Jan 2025 · 0 likes post #111 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
-
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #102 · Analytics › Method validation · 24 Dec 2024 · 5 likes Why two laboratories may disagree: after validating the same method, they may still report different purity on the same sample due to integration differences, column…
-
Coming back to: An 18-month record including the parts that went badly Replied, post #2 · marked as the solution · Outcomes › Progress reports · 22 Dec 2024 · 8 likes On the opening post — agreed on the reasoning, with one qualification. Measurement noise: day-to-day body mass varies by more than a kilogram on hydration, glycogen,…
-
[2026 update] New subcategory: rationale and scope Replied, post #62 · Meta › Announcements · 13 Dec 2024 · 7 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
-
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #58 · Compounds › Semaglutide · 7 Dec 2024 · 0 likes post #57 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
-
Injection-site reactions: describing them precisely enough to be useful Replied, post #44 · Practice › Side effects · 3 Dec 2024 · 15 likes Hair shedding: telogen effluvium associated with rapid weight loss is reported. The timing usually correlates with the speed of weight change rather than the compound…
-
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #82 · Analytics › Method validation · 27 Nov 2024 · 7 likes System suitability: injections run at the start of a batch to establish that the instrument and column are performing. Acceptance criteria typically include replicate…
-
Converting between mg/mL and units per dose, both directions Replied, post #69 · Practice › Reconstitution · 29 Oct 2024 · 0 likes Foaming during reconstitution: bubbles in the solution are usually just air incorporated during mixing. They usually resolve with gentle warming and time. Persistent…
-
Turnaround times and what they mean for a decision — one year on Replied, post #10 · Sourcing › Independent verification · 28 Oct 2024 · 4 likes Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies…
-
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #100 · Clinical › Comorbidities · 25 Oct 2024 · 33 likes Type 2 diabetes: the population with the largest evidence base for these compounds. The SURPASS and SUSTAIN programmes established glycaemic benefit. The renal and…
-
Requesting a page: what makes a good request — what changed since Replied, post #107 · Documentation › Wiki requests · 12 Oct 2024 · 17 likes Scope creep: if you think a page is attempting too much and should be split into multiple pages, that is a reasonable suggestion.
-
Second pass at: A payment that went through twice: how it was resolved Started this topic · Sourcing › Payments · 16 Sep 2024 · 2 likes On the subject in the title: Second pass at: A payment that went through twice: how it was resolved Working notes rather than a conclusion. A logistics question, since…
-
The topic list is dense — is that deliberate? Replied, post #20 · Meta › Site feedback · 31 Aug 2024 · 32 likes Feature requests: if the site would work better with a feature it does not have (better search, different filtering, new section) suggest it here with the reasoning.
-
Tracking a preprint to publication: a worked example — the long version Replied, post #25 · Evidence › Preprints · 11 Aug 2024 · 14 likes Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for…
-
Tracking a preprint to publication: a worked example — the long version Replied, post #4 · Evidence › Preprints · 31 May 2024 · 30 likes Unrefereed work is not worthless. A great deal of it survives review substantially unchanged. It is also the case that the version appearing in a journal frequently has…