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On the live site this tab tracks what you have not read. In this static rendering it shows every topic with activity in the last 45 days, which is the closest honest equivalent — we would rather explain the difference than pretend a static page knows your reading history.

414 topics · page 11 of 14

Topic	Participants	Replies	Views	Activity
A pooled estimate that changed when one trial was added Evidence › Meta-analyses meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…	+24	28	3.5k	2d
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with STEP 4 (…	+109	116	36k	2d
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+55	59	26k	2d
[2026 update] Currency conversion and the cost you did not see Sourcing › Payments research use only payments documentation quality Solved Posting this under the heading it deserves: Currency conversion and the cost you did not see Everything below is what sits behind that. A logistics question, since the answers here are usually better than…	+21	26	52k	2d
When your prescriber and the evidence disagree Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes When your prescriber and the evidence disagree — that is the question, and I have not found it answered plainly anywhere I have looked. General question, not a request for advice about my own care — I know…	+14	18	273	2d
Priming a pen and whether the primed volume is wasted Devices › Pens & autoinjectors storage missed dose dead volume Solved Wiki Priming a pen and whether the primed volume is wasted Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+19	23	1.3k	2d
Semaglutide and alcohol: what is actually documented Compounds › Semaglutide STEP programme randomised trial type 2 diabetes SELECT trial Posting this under the heading it deserves: Semaglutide and alcohol: what is actually documented Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim I do…	+14	18	10k	2d
Search filters: what is missing Meta › Site feedback site feedback moderation guidelines Search filters: what is missing — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps being…	+74	84	15k	3d
Second pass at: Which categories are strict and which are relaxed, honestly Start Here › Welcome guidelines beginner friendly trust levels onboarding Wiki On the subject in the title: Second pass at: Which categories are strict and which are relaxed, honestly Working notes rather than a conclusion. Question in the title. Context below, and I have tried to…	+93	99	36k	3d
Blinding yourself: practical methods and their limits Research Methods › N-of-1 designs confounding data table effect size On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with STEP 4 ( JAMA , 2021) and finding the…	+40	44	33k	5d
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation linearity recovery precision & repeatability system suitability On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Working notes rather than a conclusion. Posting the method first, because I know what the first…	+93	99	1.4k	6d
A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipid panel HbA1c liver enzymes lipase & amylase Posting this under the heading it deserves: A single out-of-range value on an otherwise normal panel Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+70	75	20k	6d
eGFR fluctuation and the creatinine denominator problem Clinical › Bloodwork eGFR & renal function liver enzymes lipid panel On the subject in the title: eGFR fluctuation and the creatinine denominator problem Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…		2	10k	6d
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Devices › Syringes & needles syringe units subcutaneous injection needle gauge & length dead volume Wiki 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how quickly…	+104	114	6k	6d
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club estimand risk of bias number needed to treat Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SUSTAIN 6 ( N Engl…	+108	122	52k	7d
Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? Compounds › Semaglutide type 2 diabetes randomised trial semaglutide SELECT trial Solved Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA ,…	+5	9	30k	8d
Preservatives: function, testing, and limits — one year on Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. tirzepatide…	+28	32	437	8d
[2026 update] Journal club: FLOW and the renal composite, component by component Evidence › Journal club journal club randomised trial estimand Journal club: FLOW and the renal composite, component by component Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…		2	21k	9d
Substitution between formats during a shortage — what changed since Access › Shortages shortage formulary FDA compounding Solved Substitution between formats during a shortage — what changed since — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is…	+17	21	2.7k	9d
Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis ipamorelin observational data GHRP class tesamorelin Solved Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with STEP…		2	25k	9d
Pages past their review date, listed — does this still hold? Meta › Wiki maintenance review date moderation maintainership wiki post Asking directly, because I could not find a straight answer: Pages past their review date, listed — does this still hold? Nominating something for promotion into the documentation commons. The topic in…	+49	56	39k	11d
Manufacturer assistance programmes and their eligibility rules Access › Pricing formulary data table compounding On the subject in the title: Manufacturer assistance programmes and their eligibility rules Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category…	+37	42	32k	11d
Why I now write the concentration on the vial in marker Practice › Reconstitution syringe units bacteriostatic water concentration maths Asking directly, because I could not find a straight answer: Why I now write the concentration on the vial in marker Practical question with the units stated, because I have seen how quickly these go wrong…	+1	5	30k	11d
Why we ask for units every single time, with three examples of what goes wrong Start Here › How to Ask worked example onboarding beginner friendly guidelines Why we ask for units every single time, with three examples of what goes wrong — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below,…	+118	135	2.2k	11d
Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis blood pressure Heart failure with preserved ejection fraction: symptom endpoints — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+19	23	311	12d
Tirzepatide storage and stability: what is published versus what is assumed Compounds › Tirzepatide SURPASS programme randomised trial SURMOUNT programme effect size On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read…	+17	21	17k	12d
I have no scientific background — can I still follow the analytics categories? Start Here › Welcome onboarding beginner friendly trust levels The question in the title: I have no scientific background — can I still follow the analytics categories? I will give what I have already checked below so nobody repeats it. I want to check my reasoning…	+29	40	1.4k	12d
The anatomy of a question that gets answered within an hour — does this still hold? Start Here › How to Ask beginner friendly onboarding site feedback guidelines The anatomy of a question that gets answered within an hour — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context…	+19	23	40k	14d
Follow-up: Reconciling a label claim with a content assay Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Reconciling a label claim with a content assay Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it anywhere.…	+26	30	6.5k	14d
What to include when your question involves a chromatogram — one year on Start Here › How to Ask worked example guidelines site feedback onboarding Asking directly, because I could not find a straight answer: What to include when your question involves a chromatogram — one year on Question in the title. Context below, and I have tried to include the…	+69	75	862	14d