Latest topics page 14
Topics ordered by most recent activity across all 71 subcategories.
1,535 topics · page 14 of 52
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Semaglutide and alcohol: what is actually documented
Posting this under the heading it deserves: Semaglutide and alcohol: what is actually documented Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim I do…
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+14 | 18 | 10k | 2d |
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Search filters: what is missing
Search filters: what is missing — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps being…
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+74 | 84 | 15k | 3d |
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Second pass at: Which categories are strict and which are relaxed, honestly
On the subject in the title: Second pass at: Which categories are strict and which are relaxed, honestly Working notes rather than a conclusion. Question in the title. Context below, and I have tried to…
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+93 | 99 | 36k | 3d |
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Blinding yourself: practical methods and their limits
On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with STEP 4 ( JAMA , 2021) and finding the…
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+40 | 44 | 33k | 5d |
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Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with real criteria
On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Working notes rather than a conclusion. Posting the method first, because I know what the first…
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+93 | 99 | 1.4k | 6d |
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A single out-of-range value on an otherwise normal panel
Posting this under the heading it deserves: A single out-of-range value on an otherwise normal panel Everything below is what sits behind that. General question, not a request for advice about my own care — I…
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+70 | 75 | 20k | 6d |
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eGFR fluctuation and the creatinine denominator problem
On the subject in the title: eGFR fluctuation and the creatinine denominator problem Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…
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2 | 10k | 6d | |
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0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how quickly…
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+104 | 114 | 6k | 6d |
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Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SUSTAIN 6 ( N Engl…
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+108 | 122 | 52k | 7d |
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Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit?
Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA ,…
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+5 | 9 | 30k | 8d |
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Preservatives: function, testing, and limits — one year on
On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. tirzepatide…
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+28 | 32 | 437 | 8d |
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[2026 update] Journal club: FLOW and the renal composite, component by component
Journal club: FLOW and the renal composite, component by component Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…
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2 | 21k | 9d | |
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Substitution between formats during a shortage — what changed since
Substitution between formats during a shortage — what changed since — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is…
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+17 | 21 | 2.7k | 9d |
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Evidence quality in the secretagogue literature: an honest assessment
Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with STEP…
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2 | 25k | 9d | |
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Pages past their review date, listed — does this still hold?
Asking directly, because I could not find a straight answer: Pages past their review date, listed — does this still hold? Nominating something for promotion into the documentation commons. The topic in…
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+49 | 56 | 39k | 11d |
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Manufacturer assistance programmes and their eligibility rules
On the subject in the title: Manufacturer assistance programmes and their eligibility rules Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category…
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+37 | 42 | 32k | 11d |
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Why I now write the concentration on the vial in marker
Asking directly, because I could not find a straight answer: Why I now write the concentration on the vial in marker Practical question with the units stated, because I have seen how quickly these go wrong…
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+1 | 5 | 30k | 11d |
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Why we ask for units every single time, with three examples of what goes wrong
Why we ask for units every single time, with three examples of what goes wrong — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below,…
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+118 | 135 | 2.2k | 11d |
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Heart failure with preserved ejection fraction: symptom endpoints
Heart failure with preserved ejection fraction: symptom endpoints — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…
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+19 | 23 | 311 | 12d |
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Tirzepatide storage and stability: what is published versus what is assumed
On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read…
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+17 | 21 | 17k | 12d |
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I have no scientific background — can I still follow the analytics categories?
The question in the title: I have no scientific background — can I still follow the analytics categories? I will give what I have already checked below so nobody repeats it. I want to check my reasoning…
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+29 | 40 | 1.4k | 12d |
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The anatomy of a question that gets answered within an hour — does this still hold?
The anatomy of a question that gets answered within an hour — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context…
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+19 | 23 | 40k | 14d |
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Follow-up: Reconciling a label claim with a content assay
Reconciling a label claim with a content assay Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it anywhere.…
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+26 | 30 | 6.5k | 14d |
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What to include when your question involves a chromatogram — one year on
Asking directly, because I could not find a straight answer: What to include when your question involves a chromatogram — one year on Question in the title. Context below, and I have tried to include the…
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+69 | 75 | 862 | 14d |
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Osteoarthritis and mechanical versus metabolic improvement — one year on
On the subject in the title: Osteoarthritis and mechanical versus metabolic improvement — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…
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+52 | 56 | 8.1k | 15d |
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[2026 update] Does a peptide degrade silently, with no visual change?
Does a peptide degrade silently, with no visual change? — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a gap,…
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+82 | 86 | 24k | 15d |
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Racemisation and why it is invisible to a mass measurement — what changed since
Racemisation and why it is invisible to a mass measurement — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I…
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+11 | 15 | 42k | 16d |
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[2026 update] Area percent versus weight percent: the confusion that causes most arguments
On the subject in the title: Area percent versus weight percent: the confusion that causes most arguments Working notes rather than a conclusion. Posting the method first, because I know what the first three…
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+65 | 70 | 1.1k | 16d |
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Interim analyses and stopping rules
Interim analyses and stopping rules Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do not think…
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+25 | 29 | 35k | 16d |
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Secretagogues and glucose tolerance: the mechanistic concern
On the subject in the title: Secretagogues and glucose tolerance: the mechanistic concern Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…
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+64 | 70 | 52k | 17d |