Latest topics page 16

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 16 of 52

Topic	Participants	Replies	Views	Activity
Does dual agonism explain the effect size, or is it dose? Compounds › Tirzepatide SURPASS programme SURMOUNT programme tirzepatide randomised trial Solved Does dual agonism explain the effect size, or is it dose? I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SURPASS-4 ( Lancet , 2021). Please read it…	+62	68	2.6k	29d
Follow-up: Search filters: what is missing Meta › Site feedback guidelines site feedback moderation On the subject in the title: Search filters: what is missing Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question keeps being…	+126	141	1.6k	29d
Follow-up: How to disagree with an answer you were given, well Start Here › How to Ask onboarding worked example guidelines site feedback How to disagree with an answer you were given, well I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to include…		2	16k	30d
Cold solution and stinging: the simplest fix Practice › Administration injection site rotation subcutaneous injection missed dose Posting this under the heading it deserves: Cold solution and stinging: the simplest fix Everything below is what sits behind that. Reporting something rather than asking about it, in case the pattern is…	+35	39	8.2k	30d
Second pass at: Programming during a large energy deficit Nutrition & Training › Resistance training DXA lean mass loss fatigue Posting this under the heading it deserves: Second pass at: Programming during a large energy deficit Everything below is what sits behind that. Longitudinal report with the method stated, because a number…	+44	48	632	30d
Stability of BPC-157 in solution: what has been measured Compounds › Repair & healing peptides BPC-157 observational data needs a source TB-500 Stability of BPC-157 in solution: what has been measured — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with FLOW ( N Engl J Med , 2024) and finding the…		2	805	30d
Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? Compounds › Repair & healing peptides needs a source preprint BPC-157 Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURPASS-2 ( N Engl J…	+28	33	1.6k	1mo
A plateau that disappeared when I changed how I measured — the long version Outcomes › Progress reports effect size data table long read A plateau that disappeared when I changed how I measured — the long version — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number…	+49	54	9.4k	1mo
Coming back to: What the published dose-response for semaglutide actually looks like above 2.4 mg Compounds › Semaglutide effect size type 2 diabetes semaglutide STEP programme Solved The question in the title: What the published dose-response for semaglutide actually looks like above 2.4 mg I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N Engl J…	+23	27	9.9k	1mo
Pinch or no pinch, and how needle length changes the answer — the long version Practice › Administration injection site rotation injection site reaction missed dose aseptic technique On the subject in the title: Pinch or no pinch, and how needle length changes the answer — the long version Working notes rather than a conclusion. I have read the maintained page on this and I still have a…	+75	79	1.5k	1mo
Gastro-oesophageal reflux: improving or worsening? Clinical › Comorbidities PCOS obstructive sleep apnoea MASH / hepatic steatosis chronic kidney disease Solved The question in the title: Gastro-oesophageal reflux: improving or worsening? I will give what I have already checked below so nobody repeats it. Asking about a population rather than about a person. The…	+54	58	8.2k	1mo
[2026 update] A vial that will not fully dissolve: what to check and in what order Practice › Reconstitution concentration maths dead volume bacteriostatic water syringe units Solved Posting this under the heading it deserves: A vial that will not fully dissolve: what to check and in what order Everything below is what sits behind that. Practical question with the units stated, because I…	+114	128	20k	1mo
Run-in periods and the population they select Evidence › Trials surrogate endpoints discontinuation & dropout estimand randomised trial On the subject in the title: Run-in periods and the population they select Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+130	142	7.3k	1mo
How to disagree with an answer you were given, well Start Here › How to Ask beginner friendly site feedback worked example guidelines Solved Wiki How to disagree with an answer you were given, well — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to include…	+9	13	1.6k	1mo
Second pass at: Temperature logging at home: what is worth the effort Practice › Storage & stability temperature excursion cloudy or discoloured solution freeze-thaw cold chain Posting this under the heading it deserves: Second pass at: Temperature logging at home: what is worth the effort Everything below is what sits behind that. Reporting something rather than asking about it, in…	+4	8	29k	1mo
A checklist for reading a certificate in under two minutes Analytics › COA interpretation certificate of analysis batch & lot numbers amino acid analysis Solved A checklist for reading a certificate in under two minutes — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere.…	+39	46	38k	1mo
Reference intervals: how they are constructed and why one in twenty flags Clinical › Bloodwork HbA1c thyroid function eGFR & renal function lipase & amylase Under review Reference intervals: how they are constructed and why one in twenty flags — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I…	+104	119	30k	1mo
Journal club: SELECT, absolute risk, and how it was reported Evidence › Journal club journal club estimand randomised trial effect size Journal club: SELECT, absolute risk, and how it was reported Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read…		2	52k	1mo
Batch numbers that do not match the vial label — what changed since Sourcing › Red flags underdosing documentation quality disputed moderation Solved On the subject in the title: Batch numbers that do not match the vial label — what changed since Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+39	43	14k	1mo
An appeal that succeeded, with the letter structure — the long version Access › Insurance & coverage appeals formulary insurance An appeal that succeeded, with the letter structure — the long version — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that…	+113	136	32k	1mo
Official shortage notices and what they authorise Access › Shortages compounding formulary shortage Posting this under the heading it deserves: Official shortage notices and what they authorise Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+106	119	18k	1mo
A parcel stationary at a customs facility for nine days Sourcing › Logistics customs packaging cold chain temperature excursion On the subject in the title: A parcel stationary at a customs facility for nine days Working notes rather than a conclusion. A logistics question, since the answers here are usually better than anywhere else…	+64	72	51k	1mo
MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Analytics › Mass spectrometry charge states LC-MS MALDI-TOF counter-ion content Closed Posting this under the heading it deserves: MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Everything below is what sits behind that. Working through the identity…	+34	39	21k	1mo
Second pass at: Where impurities in solid-phase peptide synthesis come from Analytics › Impurities & related substances HPLC water content counter-ion content endotoxin testing Second pass at: Where impurities in solid-phase peptide synthesis come from Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an…	+4	8	7.2k	1mo
[2026 update] Are there stupid questions here? A staff answer, at length Start Here › Welcome guidelines trust levels onboarding Solved Closed Are there stupid questions here? A staff answer, at length — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to…	+36	40	2.4k	1mo
Revisiting: Bioimpedance and hydration: why the number moves Outcomes › Body composition data table DXA bioimpedance Solved Posting this under the heading it deserves: Revisiting: Bioimpedance and hydration: why the number moves Everything below is what sits behind that. Longitudinal report with the method stated, because a number…		2	2.8k	1mo
A parcel stationary at a customs facility for nine days — does this still hold? Sourcing › Logistics temperature excursion packaging cold chain customs Solved The question in the title: A parcel stationary at a customs facility for nine days — does this still hold? I will give what I have already checked below so nobody repeats it. A logistics question, since the…	+23	27	12k	1mo
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Sourcing › Independent verification PeptideMeter VendorInvestigate third-party testing Janoshik Analytical Asking directly, because I could not find a straight answer: How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Structured report rather than an opinion, following the…	+24	28	8k	1mo
Dizziness on standing and the electrolyte explanation — does this still hold? Practice › Side effects vomiting hair shedding nausea constipation Solved The question in the title: Dizziness on standing and the electrolyte explanation — does this still hold? I will give what I have already checked below so nobody repeats it. I have read the maintained page on…	+89	94	18k	1mo
Injecting into an area that has become firm: why not to Practice › Administration subcutaneous injection injection site rotation injection site reaction aseptic technique Solved Injecting into an area that has become firm: why not to Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+82	92	26k	1mo