Latest topics page 18

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 18 of 52

Topic	Participants	Replies	Views	Activity
Documenting a payment dispute without naming and shaming Sourcing › Payments documentation quality research use only payments Documenting a payment dispute without naming and shaming — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately from…	+5	9	9.8k	2mo
Peak-to-trough ratio at steady state for a weekly agent Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose Solved On the subject in the title: Peak-to-trough ratio at steady state for a weekly agent Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…	+58	64	9.7k	2mo
Restarting after a long gap: what the labelling implies — the long version Practice › Dosing & titration tirzepatide worked example dose reduction semaglutide Restarting after a long gap: what the labelling implies — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+12	17	2.4k	2mo
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide tirzepatide SURMOUNT programme effect size randomised trial Solved Tirzepatide and nausea: is the profile genuinely different or just differently reported? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J…	+109	122	3.6k	2mo
Revisiting: Mean kinetic temperature explained without the mathematics Practice › Storage & stability storage cold chain temperature excursion cloudy or discoloured solution Solved Revisiting: Mean kinetic temperature explained without the mathematics Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I…	+67	75	909	2mo
Blind submission and why it changes minds — the long version Sourcing › Independent verification Medutest third-party testing Janoshik Analytical Posting this under the heading it deserves: Blind submission and why it changes minds — the long version Everything below is what sits behind that. Structured report rather than an opinion, following the…	+98	113	18k	2mo
Counter-ion form: the field almost nobody reports Analytics › COA interpretation certificate of analysis documentation quality batch & lot numbers Solved Counter-ion form: the field almost nobody reports Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…		3	11k	2mo
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction — one year on Compounds › Retatrutide preprint retatrutide TRIUMPH programme randomised trial Why a glucagon receptor agonist in a weight-loss compound is not a contradiction — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 (…	+3	7	1k	2mo
Moderation log format change Meta › Announcements trust levels guidelines site feedback moderation Posting this under the heading it deserves: Moderation log format change Everything below is what sits behind that. Process question about how this site works. I have read the guidelines and the trust-level…	+53	57	4.8k	2mo
The best-written scientific paper you have read Lounge › Off topic long read beginner friendly The best-written scientific paper you have read Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if anyone makes a…	+69	74	1.1k	2mo
What a confidence interval means, from scratch Research Methods › Statistics number needed to treat confounding worked example heterogeneity What a confidence interval means, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim I do not…		2	2.6k	2mo
How much fluid is actually needed, and how you would know Nutrition & Training › Hydration & electrolytes heart rate blood pressure fatigue Solved The question in the title: How much fluid is actually needed, and how you would know I will give what I have already checked below so nobody repeats it. Maintenance rather than loss, which is the part of this…	+11	15	53k	2mo
Personal import allowances, compared — a second dataset Access › International personal import telehealth MHRA EMA Wiki Personal import allowances, compared — a second dataset — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what…	+124	132	9.2k	2mo
Comparing the STEP programme populations: who was actually enrolled Compounds › Semaglutide SELECT trial STEP programme semaglutide effect size Solved Comparing the STEP programme populations: who was actually enrolled Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med , 2021) with FLOW ( N…		2	7.5k	2mo
Introducing myself and asking whether my planned first topic belongs anywhere — does this still hold? Start Here › Welcome trust levels onboarding guidelines Solved Closed Introducing myself and asking whether my planned first topic belongs anywhere — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. I want to check…		2	36k	2mo
A 40-week log with the measurement method stated — does this still hold? Outcomes › Progress reports effect size DXA data table Solved A 40-week log with the measurement method stated — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Longitudinal report with the method stated,…	+1	5	14k	2mo
Injection discomfort: needle gauge, volume, temperature, technique Practice › Administration subcutaneous injection injection site reaction needle gauge & length aseptic technique Injection discomfort: needle gauge, volume, temperature, technique — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+66	71	14k	2mo
Why we ask for units every single time, with three examples of what goes wrong — what changed since Start Here › How to Ask onboarding guidelines worked example beginner friendly The question in the title: Why we ask for units every single time, with three examples of what goes wrong — what changed since I will give what I have already checked below so nobody repeats it. Question in…	+14	18	19k	2mo
Step therapy requirements and how to satisfy them Access › Insurance & coverage prior authorisation insurance formulary Posting this under the heading it deserves: Step therapy requirements and how to satisfy them Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is…	+21	25	49k	2mo
Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition lean mass loss data table bioimpedance DXA Solved On the subject in the title: Two scans six weeks apart on different machines: a cautionary tale Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a…	+18	26	9.4k	2mo
Citation sweep results: how many references did not say what was claimed Meta › Wiki maintenance moderation maintainership citation check wiki post On the subject in the title: Citation sweep results: how many references did not say what was claimed Working notes rather than a conclusion. Process question about how this site works. I have read the…	+92	101	2.9k	2mo
Is there a ceiling dose beyond which semaglutide stops adding benefit? Compounds › Semaglutide effect size type 2 diabetes SELECT trial Is there a ceiling dose beyond which semaglutide stops adding benefit? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in…		2	14k	2mo
Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+11	15	43k	2mo
Five questions in one post gets you one answer — how to split them Start Here › How to Ask guidelines site feedback worked example Closed On the subject in the title: Five questions in one post gets you one answer — how to split them Working notes rather than a conclusion. Question in the title. Context below, and I have tried to include the…	+84	90	1k	2mo
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one year on Compounds › Oral incretins PIONEER programme SOUL trial orforglipron Solved Asking directly, because I could not find a straight answer: Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one year on I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited…	+16	20	18k	2mo
The 2.5 mg starting dose is not a therapeutic dose — why that matters Compounds › Tirzepatide SURPASS programme SURMOUNT programme effect size Solved The 2.5 mg starting dose is not a therapeutic dose — why that matters Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…	+119	136	5.6k	2mo
The arithmetic of an intermediate dose between two label steps Practice › Dosing & titration dose reduction semaglutide missed dose On the subject in the title: The arithmetic of an intermediate dose between two label steps Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…		2	136	2mo
Revisiting: Patterns that reliably precede a problem, documented Sourcing › Red flags underdosing moderation mislabelling documentation quality Posting this under the heading it deserves: Revisiting: Patterns that reliably precede a problem, documented Everything below is what sits behind that. A logistics question, since the answers here are usually…	+16	20	36k	2mo
Reading U-100 graduations, with a conversion table — what changed since Devices › Syringes & needles worked example dead volume syringe units subcutaneous injection Reading U-100 graduations, with a conversion table — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I…		2	10k	2mo
[2026 update] Thyroid function tests during substantial weight change Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c thyroid function Thyroid function tests during substantial weight change Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+69	74	4.5k	2mo