Latest topics page 20
Topics ordered by most recent activity across all 71 subcategories.
1,535 topics · page 20 of 52
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Anaesthesia and elective surgery: the aspiration question
Posting this under the heading it deserves: Anaesthesia and elective surgery: the aspiration question Everything below is what sits behind that. A question about technique rather than about dose. I have been…
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+103 | 115 | 6.6k | 3mo |
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The "under review" status pill and when a moderator applies it
Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…
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+96 | 119 | 17k | 3mo |
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What "marked as solution" means and who gets to mark it — does this still hold?
What "marked as solution" means and who gets to mark it — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather…
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+69 | 74 | 2.4k | 3mo |
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Reimbursement variation across member states
Reimbursement variation across member states Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what…
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+7 | 11 | 39k | 3mo |
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Revisiting: A field-by-field walk through a certificate of analysis
Revisiting: A field-by-field walk through a certificate of analysis Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I…
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+37 | 41 | 656 | 3mo |
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Second pass at: What "verified" means on our vendor pages, stated narrowly
Second pass at: What "verified" means on our vendor pages, stated narrowly — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better…
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+94 | 102 | 20k | 3mo |
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Request: show the solution author in the topic list — what changed since
Request: show the solution author in the topic list — what changed since — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation…
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+85 | 91 | 20k | 3mo |
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A widely repeated interaction claim that turns out to be unsupported
On the subject in the title: A widely repeated interaction claim that turns out to be unsupported Working notes rather than a conclusion. Practical question with the units stated, because I have seen how…
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+47 | 51 | 37k | 3mo |
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Primary endpoint hierarchies and why order matters
Primary endpoint hierarchies and why order matters Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with SURPASS-2 ( N Engl J…
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4 | 308 | 3mo | |
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Stepping down deliberately, and how to do it without losing progress
Stepping down deliberately, and how to do it without losing progress — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…
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+98 | 102 | 26k | 3mo |
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[2026 update] Charge states for a 4 kDa peptide, worked through
On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…
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+116 | 135 | 31k | 3mo |
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Validating a calculator against hand arithmetic
Validating a calculator against hand arithmetic Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…
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+17 | 21 | 12k | 3mo |
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Validating a method you did not develop
On the subject in the title: Validating a method you did not develop Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A VendorInvestigate…
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+10 | 14 | 15k | 3mo |
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Type 2 diabetes and the largest part of the evidence base
Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. General question, not a request for advice about my own care —…
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+81 | 89 | 2.9k | 3mo |
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Journal club: is percentage weight change the right endpoint?
Journal club: is percentage weight change the right endpoint? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-OSA (…
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+116 | 120 | 23k | 3mo |
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Foaming during reconstitution and whether it matters — the long version
Foaming during reconstitution and whether it matters — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…
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+100 | 117 | 6k | 3mo |
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Why this community will not facilitate a group purchase
Asking directly, because I could not find a straight answer: Why this community will not facilitate a group purchase A logistics question, since the answers here are usually better than anywhere else I have…
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2 | 40k | 3mo | |
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Coming back to: Measurement error in a self-reported exposure
Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…
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+23 | 27 | 49k | 3mo |
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[2026 update] Composite endpoints and the component doing the work
On the subject in the title: Composite endpoints and the component doing the work Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet , 2021) and…
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+76 | 87 | 994 | 3mo |
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Impurity thresholds: where the common numbers come from — what changed since
Posting this under the heading it deserves: Impurity thresholds: where the common numbers come from — what changed since Everything below is what sits behind that. A documentation question rather than an…
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2 | 61k | 3mo | |
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Follow-up: What a statistical analysis plan adds that the paper does not
What a statistical analysis plan adds that the paper does not I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…
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2 | 7.2k | 3mo | |
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Converting between mg/mL and units per dose, both directions — the long version
Converting between mg/mL and units per dose, both directions — the long version Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated,…
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+110 | 132 | 1.7k | 3mo |
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Sample handling between despatch and injection
Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…
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+63 | 68 | 2.4k | 3mo |
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Managing an unplanned gap in supply
Managing an unplanned gap in supply — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the answer.…
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+105 | 110 | 5.1k | 3mo |
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[2026 update] What a purity-only report leaves out
The question in the title: What a purity-only report leaves out I will give what I have already checked below so nobody repeats it. Structured report rather than an opinion, following the format the…
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+97 | 103 | 5.2k | 3mo |
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Pregnancy and pregnancy planning: contraindication and washout
Posting this under the heading it deserves: Pregnancy and pregnancy planning: contraindication and washout Everything below is what sits behind that. General question, not a request for advice about my own…
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+111 | 122 | 2.4k | 3mo |
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Severe abdominal pain: why this is not a forum question
Posting this under the heading it deserves: Severe abdominal pain: why this is not a forum question Everything below is what sits behind that. General question, not a request for advice about my own care — I…
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2 | 17k | 3mo | |
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How to tell whether your question is already answered on a maintained page
How to tell whether your question is already answered on a maintained page — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…
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+5 | 9 | 30k | 3mo |
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Price changes over 2025 and 2026, tabulated and dated — does this still hold?
Price changes over 2025 and 2026, tabulated and dated — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated,…
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+147 | 156 | 18k | 3mo |
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Journal club: SURMOUNT-4 and continuation versus withdrawal
Journal club: SURMOUNT-4 and continuation versus withdrawal — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not…
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+32 | 36 | 31k | 3mo |